Results 81 to 90 of about 2,296,173 (238)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Seasonal and Dietary Effects on the Hematobiochemical Parameters of Creole Goats in the Peruvian Andes

Veterinary Sciences
Creole goats have adapted to the harsh Andean environment, yet the physiological impacts of high-altitude production systems remain underexplored. This study assessed seasonal and dietary influences on the hematological and biochemical profiles of 45 ...
Aníbal Rodríguez-Vargas, Emmanuel Alexander Sessarego, Katherine Castañeda-Palomino, Huziel Ormachea, Fritz Trillo, Víctor Temoche-Socola, José Antonio Ruiz-Chamorro, Juancarlos Alejandro Cruz   +7 more
doaj   +1 more source

Estudio y desarrollo de una aplicación de supervisión y control de almacenes (SGA) [PDF]

, 2013
El presente trabajo tiene como finalidad el desarrollo de una aplicación piloto de SGA (Sistema de Gestión de Almacenes) que permita el control y supervisión de una estación docente que realiza las funciones de almacén intermedio dentro de un proceso ...
Zaragoza Travieso, Bernat
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Hacia un modelo alternativo de supervisión del Prácticum [PDF]

, 2012
Dos supervisores de prácticum de profesorado propusieron a 34 estudiantes tareas de reflexión, análisis y elaboración teórica de un modelo didáctico personal, a partir de lecturas conectadas con la práctica del aula.
Jorquera Jaramillo, María Cecilia, Pineda Alfonso, José Antonio   +1 more
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Global perspectives on the biodegradation of LDPE in agricultural systems

Frontiers in Microbiology
The increasing use of plastics globally has generated serious environmental and human health problems, particularly in the agricultural sector where low-density polyethylene (LDPE) and other plastics are widely used.
Jani E. Mendoza, Daniel Tineo, Beimer Chuquibala-Checan, Nilton Atalaya-Marin, Victor H. Taboada-Mitma, Josué Tafur-Culqui, Ever Tarrillo, Darwin Gómez-Fernández, Malluri Goñas, María Andrea Reyes-Reyes, María Andrea Reyes-Reyes   +10 more
doaj   +1 more source

Mecanismo Unico de Resolución Bancaria. Aspectos Institucionales [PDF]

, 2014
El Mecanismo Único de Resolución Banca- rio es un instrumento derivado del Mecanismo de Supervisión Bancaria que permitirá cuando entre en vigor proporcionar una respuesta uni- forme desde la perspectiva de la Unión Bancaria a las crisis bancarias.
González García, Julio V.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Vorwort

Forum Supervision
Forum Supervision
doaj   +7 more sources