Results 101 to 110 of about 287,804 (302)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Complex interventions - Exploring the application of behaviour change theory to doctoral supervisor training. [PDF]
, 2018 Rationale: The student-supervisor relationship is an important factor impacting on doctoral student satisfaction and successful completion rates (e.g., Hodsdon & Buckley 2011; Kulej & Park 2008).
Lipka, Sigrid
core
Scalable soft real-time supervisor for tomographic AO
, 2018 Implementations of AO tomography for the next generation of Extremely Large Telescopes (ELTs) is challenging because of the extremely large number of degrees of freedom of such systems, in particular when it comes to the tomographic reconstructor ...
Gratadour, Damien +5 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A Suicide Attempt in a Renal Transplant Patient with Mycophenolate Sodium
Turkish Journal of Nephrology, 2019 Solid organ transplant patients have higher suicide rates compared to the general population. It is suggested that the major factor contributing to this is to be on multiple immunosupressive drugs, with some of these drugs directly or as a side effect ...
Savaş SİPAHİ +8 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Three variations of observation equivalence preserving synthesis abstraction [PDF]
, 2011 In a previous paper we introduced the notion of synthesis abstraction, which allows efficient compositional synthesis of maximally permissive supervisors for large-scale systems of composed finite-state automata.
Mohajerani, Sahar +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source