Results 111 to 120 of about 287,804 (302)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
An AI Perspective on Counseling Supervision
Behavioral SciencesThe increased use of technology-assisted distance counseling practices is one result of COVID’s impact on behavioral health, including in counselor education and the delivery of supervision.
Emily A. Brinck +6 more
doaj +1 more source
Cooperation of Supervisor, Co-Supervisor, and Statistical Advisor with Thesis and Dissertations in Tehran University of Medical Sciences: Postgraduates’ Viewpoints [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2014 Introduction: Postgraduates’ viewpoint about thesis is an area of interest for administrators of medical universities. The objective of this study is to overview postgraduates’ viewpoints about supervisors’, co-supervisors’ and statistical advisors ...
Masoud Roudbari +2 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Environmental and Occupational Health PracticeBackground: While scolding is an often problematic form of workplace communication in Japan, little research exists regarding its impact on employees’ mental health.
Kohei Mase +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
THE CULTURE OF A LEADER’S SPEECH
RUDN Journal of Public Administration, 2014 The article deals with the rules of the culture of speech. It makes recommendations on the proper organization of executives and correct formulation of the question.
N S Stolyarov
doaj
Current Issues in EducationThe current ethos and decorum in postgraduate studies thrive on the assumption that postgraduate students do not require similar academic support as undergraduate students.
Medson Mapuya
doaj +1 more source