Results 111 to 120 of about 454,783 (313)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

PERSONNEL [PDF]

1023.1. EMS agency medical director. 1023.2. Medical command physician. 1023.3. Medical command facility medical director. 1023.4. Regional EMS medical director. 1023.5. Commonwealth EMS Medical Director. § 1023.1. EMS agency medical director.
Subchapter A. Administrative, Supervisory Ems   +1 more
core  

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Testing the characteristics of macroprudential policies’ differential impact on foreign and domestic banks’ lending in Croatia

Public Sector Economics, 2020
In the aftermath of the 2008 financial crisis, macroprudential measures were labelled as policymakers’ best response to systemic risk and macro-financial imbalances, with their effectiveness still largely unknown due to limited use of such measures.
Mario Bambulovic, Miljana Valdec
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Mediação e acompanhamento na formação, educação e desenvolvimento profissional Mediación y acompañamiento en la formación educación e desarrollo profesional Mediating and monitoring training, education and professional development

Revista de Enfermagem Referência, 2012
As políticas de educação e ensino superior reconhecem a importância da aprendizagem mediada, no complexo processo de desenvolvimento da cadeia educativa: da gestão da informação à construção de conhecimento e sabedoria para agir.
Manuel Alves Rodrigues, Maria da Conceição Baía   +1 more
doaj  

ANALYSIS OF RISK-BASED ASSET MANAGEMENT PLAN TO INCREASE PERFORMANCE OF WATER LOCAL COMPANY

Jurnal Bisnis dan Manajemen, 2019
This study aims to obtain the concept of risk-based asset management planning with consideration of government regulations and international standards of asset management that can improve the performance of Regional Water Company (PDAM) of Aceh Province.
Monita Mardika Fajar, Dian Masyita, Leni Susanti   +2 more
doaj   +1 more source

Mutually Engaged Supervisory Processes: A Proposed Theory for ACPE Supervisory Education

Journal of Pastoral Care & Counseling: Advancing theory and professional practice through scholarly and reflective publications, 2012
Nineteen newly certified Association for Clinical Pastoral Education (ACPE) Associate Supervisors were interviewed to determine how they learned to do Clinical Pastoral Education (CPE) supervision. Grounded theory was the qualitative research method used in gathering and analyzing data for this IRB approved study. The emerging theory, Mutually Engaged
Judith R. Ragsdale, Mary Ellen Steele-Pierce, Carole H Bergeron, Canon William E Scrivener   +3 more
openaire   +3 more sources