Results 131 to 140 of about 41,229 (313)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Impacts of 3D visualizations and virtual reality in display designs for remote monitoring of satellite operations

Frontiers in Virtual Reality
IntroductionRemote supervision and monitoring of autonomous systems is an important modality for future operations including spaceflight, manufacturing, and transportation.
Savannah L. Buchner, Abigail Rindfuss, Jennifer Wood, Hanspeter Schaub, Allison P. Hayman   +4 more
doaj   +1 more source

Verification of the observer property in discrete event systems [PDF]

, 2014
The observer property is an important condition to be satisfied by abstractions of Discrete Event System (DES) models. This technical note presents a new algorithm that tests if an abstraction of a DES obtained through natural projection has the observer
Pena, Patricia N., da Cunha, A. E. C., Malik, Robi, Cury, José E. R., Lafortune, S., Bravo, H. J.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Robust power control for PV and battery systems: integrating sliding mode MPPT with dual buck converters

Frontiers in Energy Research
This paper presents a comprehensive exploration of an integrated Buck-Boost converter and Sliding Mode Control (SMC) Maximum Power Point Tracking (MPPT) system for optimizing photovoltaic energy conversion.
Arezki Fekik, Arezki Fekik, Mohamed Lamine Hamida, Ahmad Taher Azar, Ahmad Taher Azar, Ahmad Taher Azar, Malek Ghanes, Arezki Hakim, Hakim Denoun, Ibrahim A. Hameed   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Set Covering Approach to Design Maximally Permissive Supervisors for Flexible Manufacturing Systems

Mathematics
The supervisory control of Petri nets aims to enforce the undesired behavior as unreachable by designing a set of control places. This work presents a set cover approach to design maximally permissive supervisors.
Yongyao Li, Yufeng Chen, Rui Zhou
doaj   +1 more source

Cross border banking supervision : incentive conflicts in supervisory information sharing between home and host supervisors [PDF]

The global financial crisis has uncovered a number of weaknesses in the supervision and regulation of cross border banks. One such weakness was the lack of effective cooperation among banking supervisors.
D'Hulster, Katia
core  

Compositional synthesis of discrete event systems via synthesis equivalence [PDF]

, 2008
A two-pass algorithm for compositional synthesis of modular supervisors for largescale systems of composed finite-state automata is proposed. The first pass provides an efficient method to determine whether a supervisory control problem has a solution ...
Malik, Robi, Flordal, Hugo
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source