Results 111 to 120 of about 9,445,647 (302)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A supervisory control approach for Digit navigation on inclined terrain

Poulakakis, IoannisHumanoid robots are engineered to replicate human capabilities, including navigating inclined terrains with stable locomotion. Humans exhibit remarkable adaptive capability to safely traverse inclined terrains without sight, adjusting ...
Sinha, Shantani
core   +1 more source

Impacts of 3D visualizations and virtual reality in display designs for remote monitoring of satellite operations

Frontiers in Virtual Reality
IntroductionRemote supervision and monitoring of autonomous systems is an important modality for future operations including spaceflight, manufacturing, and transportation.
Savannah L. Buchner, Abigail Rindfuss, Jennifer Wood, Hanspeter Schaub, Allison P. Hayman   +4 more
doaj   +1 more source

Sensors Data Analysis in Supervisory Control and Data Acquisition (SCADA) Systems to Foresee Failures with an Undetermined Origin. [PDF]

Sensors (Basel), 2021
Maseda FJ, López I, Martija I, Alkorta P, Garrido AJ, Garrido I.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Yet another approach to compositional synthesis of discrete event systems [PDF]

, 2008
A two-pass algorithm for compositional synthesis of modular supervisors for large-scale systems of composed finite-state automata is proposed. The first pass provides an efficient method to determine whether a supervisory control problem has a solution ...
Hugo Flordal, Malik, Robi, Flordal, Hugo, Robi Malik, Malik, Robi,, Flordal, Hugo,   +5 more
core   +1 more source

Robust power control for PV and battery systems: integrating sliding mode MPPT with dual buck converters

Frontiers in Energy Research
This paper presents a comprehensive exploration of an integrated Buck-Boost converter and Sliding Mode Control (SMC) Maximum Power Point Tracking (MPPT) system for optimizing photovoltaic energy conversion.
Arezki Fekik, Arezki Fekik, Mohamed Lamine Hamida, Ahmad Taher Azar, Ahmad Taher Azar, Ahmad Taher Azar, Malek Ghanes, Arezki Hakim, Hakim Denoun, Ibrahim A. Hameed   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Discrete hierarchical supervisory control for autonomous underwater vehicle

, 2004
Autonomous Underwater Vehicle (AUV) is an unmanned untethered underwater vehicle managed by its control architecture. If we want AUV to undertake a user-specified mission without the presence of human, the control system should have enough machine ...
Feng XS(封锡盛), Zhang Y(张禹), Xu HL(徐红丽)   +2 more
core  

Annual report 2015 [PDF]

, 2016
The Financial Supervisory Authority in brief 2 Director General’s review 3 The FIN-FSA’s strategy 2016–2018 5 The operating environment and financial position of supervised entities 6 Supervised entities’ strong risk resilience and high-quality ...

core