Results 91 to 100 of about 583,973 (248)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Visual performance and safety benefits of adaptive driving beam headlighting systems. [PDF]

Recent developments in solid-state lighting, sensor and control technologies are making newconfigurations for vehicle forward lighting feasible. Building on systems that automatically switch fromhigh- to low-beam headlights in the presence of oncoming ...
Skinner, Nicholas P., Plummer, Timothy T., Bullough, John D., Rensselaer Polytechnic Institute. Lighting Research Center   +3 more
core  

Why Directionality Is an Important Light Factor for Human Health to Consider in Lighting Design? [PDF]

, 2016
Both image-forming and non-image-forming effects of radiation require proper attention in lighting design that aims at meeting human vision and health requirements.
van Loenen, E.J., Rosemann, A.L.P., Rosemann, Alexander, Loenen, EJ Evert van, Aries, Myriam, Van Loenen, Evert, Parisa Khademagha, Khademagha, P Parisa, Rosemann, ALP Alexander, Khademagha, Parisa, Khademagha, P., Alexander Rosemann, Evert Van Loenen, Aries, M.B.C., Aries, MBC Myriam, Myriam Aries   +15 more
core   +3 more sources

The Direction of Far-red Light Is Crucial in Strawberry Cultivation

HortTechnology
In this study, strawberry ‘Keepsake’ plants were exposed to supplemental far-red (FR) light from above or the sides at a level of 40.2 μmol·m−2·s−1 and a peak wavelength of 730 nm. A control was also included, in which plants received only natural light (
Fraidoon Karimi
doaj   +1 more source

Integrating omics reveals insights into tomato abaxial/adaxial leafy supplemental lighting. [PDF]

Front Plant Sci, 2023
Jiang C, Wu H, Zhang X, Liu J, Li Y, Song Y, Wang J, Zheng Y.   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The effect of LED lighting on photosynthetic parameters and weight of lamb’s lettuce (Valerianella locusta)

Folia Horticulturae, 2013
The experiment was carried out in the winter and autumn of 2011 using lamb’s lettuce (Valerianella locusta Laterr. Em Betce) as a test plant under greenhouse growing conditions.
Wojciechowska Renata, Kołton Anna, Długosz-Grochowska Olga, Żupnik Marek, Grzesiak Wojciech   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source