Results 101 to 110 of about 302,216 (254)

DHA supplementation alone or in combination with other nutrients does not modulate cerebral hemodynamics or cognitive function in healthy older adults [PDF]

, 2016
A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy ...
Kennedy, David O, Dick, James, Kennedy, David, David Kennedy, Younger, Irene, Jackson, Philippa A, Bell, Gordon, Irene Younger, Philippa Jackson, Dick, James R, Jackson, Philippa, Joanne Forster, J. Bell, Forster, Joanne S, Bell, J Gordon, James Dick, Forster, Joanne   +16 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Anaemia among school children of different socioeconomical status in a city of Southern Brazil

Annals of Human Biology
Background: Iron deficiency is one of the leading causes of anaemia, with those most affected being children and women of childbearing age, in Brazil there is a scarcity of studies involving the local prevalence of anaemia.
Karini da Rosa, Luana Beatriz Limberger, Maiara de Queiroz Fischer, Caroline dos Santos, Cézane Priscila Reuter, Charise Dallazem Bertol, Jorge André Horta, Silvia Isabel Rech Franke, Daniel Prá   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Circulating Glutathione Peroxidase-3 in Elderly—Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme Q₁₀ Supplementation

Antioxidants
Low-selenium status was associated with impaired renal function, which improved after selenium and coenzyme Q10 supplementation in an RCT. Here, we evaluated serum glutathione peroxidase-3 (GPx3) and its relation to serum selenium, selenoprotein P ...
Jan Alexander, Jan Olav Aaseth, Lutz Schomburg, Thilo Samson Chillon, Anders Larsson, Urban Alehagen   +5 more
doaj   +1 more source

Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. [PDF]

, 2013
BACKGROUND: Intestinal damage and malabsorption caused by chronic environmental enteropathy are associated with growth faltering seen in infants in less-developed countries.
Drammeh, Saikou, Stephen Young, Andrew M Prentice, van der Merwe, Liandré F, Young, Stephen, Fulford, Anthony J, Halliday, Katherine E, Prentice, Andrew M, Saikou Drammeh, Sophie E Moore, Anthony J Fulford, Moore, Sophie E, Liandré F van der Merwe, Katherine E Halliday   +13 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Characterization of Chestnut Tannins: Bioactive Compounds and Their Impact on Lamb Health

Life
The objective of the present study was to characterize the chestnut (Castanea sativa Mill.) tannin product, Farmatan Plus® (Tanin Sevnica d.d., Sevnica, Slovenia), and to subsequently examine its effects on the blood metabolic parameters of fattening ...
Bogdan Cekić, Jordan Marković, Vuk Maksimović, Dragana Ružić-Muslić, Nevena Maksimović, Ivan Ćosić, Krstina Zeljić Stojiljković   +6 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source