Results 71 to 80 of about 14,629 (266)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
PLoS ONEThis paper delves into the impact of supply chain integration on corporate innovation performance. Utilizing panel data from 1,038 manufacturing companies listed on China's A-shares stock market from 2012 to 2021, it analyzes how firms influence their ...
Juanmei Zhou, Jie Mei
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2020 Günümüzde rekabet edebilirlik için tedarikçilerle entegrasyon son derece önemlidir. Firmaların tedarikçileri ile entegre olabilmeleri için ise tedarik zincirinde bilgi teknolojilerinin kullanımına önem vermeleri ve bilgiyi yönetmeleri gerekmektedir.
Bülent Yıldız, Behzat Sayın
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Havacılık ve Uzay Teknolojileri Dergisi, 2018 In recent years, considering the evolution of consciousness about firms’ and their partners’ environmental and social responsibility, briefly sustainability, has become an important theme for enterprises.
Funda Seçkin, Ceyda Güngör Şen
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
INTEGRATED SUPPLY CHAIN OF SUPPLIER AND RETAILER FOR STOCHASTIC DEMAND
Mathematical Modelling and Analysis, 2018 This article deals with a two-stage supply chain comprising of the retailer and the supplier in which demand of the end customers follows news-vendor type demand. The setup costs, purchasing and procurement costs are dependent on lot sizes. The mathematical models for continuous and discrete variables of the chain are analyzed mathematically to ...
Sunil Tiwari +2 more
openaire +5 more sources