Results 81 to 90 of about 14,629 (266)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Drivers of innovation in the European Food Industry: Evidences from the Community Innovation Survey
International Journal on Food System Dynamics, 2015 Cooperation is particularly important for innovation in the food industry. as it has traditionally been considered as a “low tech” sector. This paper analyses how different forms of cooperation affect innovation activities in the EU’s ...
Stefano Ciliberti +2 more
doaj
LogisticsBackground: Supplier involvement in product development has proven beneficial for companies and is a phenomenon researched in various domains. The definitions of supplier involvement represent points of origin and dimensions addressed in research. Still,
Filip Flankegård +3 more
doaj +1 more source
Supplier development: How to improve suppliers order-to delivery and learn from supplier integration
, 2021 Introduction Companies that fail to integrate important suppliers are risking omitting meaningful collaborations and consequently lose market advantages. However, developing a relationship towards an integrated collaboration includes complex components in a buyer-supplier relationship that creates a higher interdependence between firms.
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
مدیریت بهره وریThis study aims to investigate the unique features of the food supply chain, examining the impact of food supply chain integration, consisting of internal integration, supplier and customer, the quality of food products and product innovation capability.
Abolfazl Kazzazi, Amir Mohammad khani
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
NOVAS TECNOLOGIAS E DESEMPENHO OPERACIONAL: UM ESTUDO INTERNACIONAL COMPARATIVO [PDF]
RAE: Revista de Administração de Empresas, 2014 This study investigates the influence of new technology anticipation by manufacturing firms on performance. Complementarily, a comparative analysis between Brazilian and plants located in other countries was performed.
Ely Laureano Paiva +2 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source