Results 141 to 150 of about 1,809,313 (357)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Pengukuran Performansi Supply Chain Berbasis Lima Proses Inti Supply Chain Operations Reference (Scor) Dengan Pendekatan Analytic Network Process (Anp) (Studi Kasus: PT Sang Hyang Seri – Persero, Cab. Pasuruan) [PDF]

, 2014
PT Sang Hyang Seri (Persero) merupakan perintis dan pelopor USAha perbenihan di Indonesia. Perusahaan ini melakukan pengolahan terhadap gabah kering panen (GKP) menjadi benih bersertifikat, dimana Perusahaan memiliki aktivitas supply chain yang digunakan
Sumantri, Y. (Yeni), Sumbayak, R. E. (Ruth), Yuniarti, R. (Rahmi)   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Critical success factors for implementation of supply chain management in Indian small and medium enterprises and their impact on performance

, 2015
Ravinder Kumar, Raj Singh, Ravi Shankar
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

An Analysis of the Development Factors of Rail Freight Transport in Thailand: A Structural Equation Modeling Approach

Infrastructures
The railway infrastructure projects in Thailand aim to shift transportation from roads to railways. This is crucial for transporting goods in emerging economies and increasing the demand for rail freight transport.
Oranicha Buthphorm, Vatcharapol Sukhotu, Thammanoon Hengsadeekul   +2 more
doaj   +1 more source

A multi-period inventory transportation model for tactical planning of food grain supply chain

, 2017
D. G. Mogale, Alexandre Dolgui, Rishabh Kandhway, Sri Krishna Kumar, Manoj Kumar Tiwari   +4 more
openalex   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Correction to: Segmentation of health-care consumers: psychological determinants of subjective health and other person-related variables

BMC Health Services Research, 2022
Sjaak Bloem, Joost Stalpers, Edward A. G. Groenland, Kees van Montfort, W. Fred van Raaij, Karla de Rooij   +5 more
doaj   +1 more source

On the dynamics of closed-loop supply chains under remanufacturing lead time variability

, 2019
Roberto Domínguez, Salvatore Cannella, Borja Ponte, José M. Framiñán   +3 more
openalex   +2 more sources