Results 141 to 150 of about 5,758,776 (359)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Environmental performance of feed additives in livestock supply chains. Guidelines for assessment

, 2020
Leap Fao
openalex   +2 more sources

Blockchain technology in supply chain operations: Applications, challenges and research opportunities

Transportation Research Part E: Logistics and Transportation Review, 2020
Pankaj Dutta, T. Choi, Surabhi Somani, Richa Butala   +3 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Building blocks for enhancing personnel performance: activities, best practices and lessons learned from Ethiopia

Journal of Pharmaceutical Policy and Practice, 2014
Daniel Taddesse, Suzanne Hoza, Tesfaye Seifu, Logan Cochrane   +3 more
doaj   +1 more source

World Class Supply Chain 2019: Next Generation Ideas [PDF]

, 2019
Next Generation Ideas, being the theme for the Fourth Annual World Class Supply Chain Summit, reflected summit’s focus on understanding what is becoming and what will continue to be of increasingly of high priority for current and future supply chain ...
Haughton, Michael
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

An Analysis of the Development Factors of Rail Freight Transport in Thailand: A Structural Equation Modeling Approach

Infrastructures
The railway infrastructure projects in Thailand aim to shift transportation from roads to railways. This is crucial for transporting goods in emerging economies and increasing the demand for rail freight transport.
Oranicha Buthphorm, Vatcharapol Sukhotu, Thammanoon Hengsadeekul   +2 more
doaj   +1 more source

Supply Chain Management of Fresh Produce: Melons in Western China [PDF]

The western part of China has a long history and reputation of growing a variety of quality melons largely due to its semi arid agronomic environment.
Qiao, Zhixia, Wei, Sherrie, Zhang, Yanrong   +2 more
core   +1 more source