Results 41 to 50 of about 16,368,583 (255)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Collaborative supply chain modelling and performance measurement [PDF]

, 2002
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 11/12/2002.For many years, supply chain research focused on operational aspects and therefore mainly on the optimisation of parts of the production and ...
Angerhofer, Bernhard J
core   +6 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Extent of Integration in Agriculture Supply Chain: The Public Sector Stakeholders perspective

Journal of Business and Social Review in Emerging Economies, 2020
Purpose: Integrating network factors (i.e. Actors, Activities, and Resources), help organizations in achieving superior supply chain performance.
Nadir Munir Hassan, Muhammad Nauman Abbasi   +1 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Design of a Green Dental Tourism Supply Chain Network: A Case Study of Qom Province [PDF]

مطالعات مدیریت توسعه سبز
Supply chain network design entails strategic decisions that critically shape the operational framework of a supply chain. The purpose of this study is to develop and optimize a green dental tourism supply chain network using metaheuristic algorithms ...
mohammad reza fathi, Mohammadjavad Pahlevanzadeh, Amirhossein Saffarinia, Samaneh Raesi Nafchi   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Supply Chain in Relation to Tourism and Crowd Management

, 2022
Proceedings of the 40th International Business Information Management Association Conference, Seville, Spain, November 23-24, 2022.The tourism industry is one of the fastest growing economic sectors in the world, and the developments in the industry are ...
Almaktoom, Abdulaziz, Shami, Atheer
core  

Horticultural supply chain network design of small and medium-sized enterprises

Sustainability Analytics and Modeling, 2023
This study investigates supply chain networks of small and medium-sized companies in the ornamental plants, perennials and cut flowers business in non-auction-driven markets such as Germany, and formulates a mathematical model depicting prevalent network
Marius Drechsler, Andreas Holzapfel
doaj   +1 more source