Results 41 to 50 of about 57,971 (259)

Green supply chain network design with emphasis on inventory decisions

Sustainable Operations and Computers, 2021
Excessive greenhouse gas emissions from the transportation sector have led companies to move towards a sustainable supply chain network design. In this study we present a new bi-objective non-linear formulation where multiple inventory components are ...
Meysam Mahjoob, Seyed Sajjad Fazeli, Soodabeh Milanlouei, Ali Kamali Mohammadzadeh, Leyla Sadat Tavassoli, James S. Noble   +5 more
doaj   +1 more source

Responsive make‐to‐order supply chain network design

Naval Research Logistics (NRL), 2020
AbstractIn this article, we address two network design problems for a responsive supply chain that consists of make‐to‐order (make‐to‐assemble) facilities facing stochastic demand and service time. The response time to customer orders, critical to the success of the supply chain, is the sum of the flow time in the facility and the delivery time to the ...
Robert Aboolian, Oded Berman, Jiamin Wang   +2 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Extent of Integration in Agriculture Supply Chain: The Public Sector Stakeholders perspective

Journal of Business and Social Review in Emerging Economies, 2020
Purpose: Integrating network factors (i.e. Actors, Activities, and Resources), help organizations in achieving superior supply chain performance.
Nadir Munir Hassan, Muhammad Nauman Abbasi   +1 more
doaj   +1 more source

Design of Supply Chain Network Model for Perishable Products with Stochastic Demand: An Optimized Model [PDF]

Journal of Optimization in Industrial Engineering, 2020
Supply chain network design in perishable product has become a challenging task due to its short life time, spoilage of product in degradation nature and stochastic market demand.
Teshome Bekele Dagne, Jeyraju Jayaprkash, Sisay Geremew Gebeyehu   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Horticultural supply chain network design of small and medium-sized enterprises

Sustainability Analytics and Modeling, 2023
This study investigates supply chain networks of small and medium-sized companies in the ornamental plants, perennials and cut flowers business in non-auction-driven markets such as Germany, and formulates a mathematical model depicting prevalent network
Marius Drechsler, Andreas Holzapfel
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source