Results 101 to 110 of about 156,131 (313)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The effect of supply chain integration, management commitment, and sustainable supply chain practices on non-profit organizations performance using SEM-FsQCA: Evidence from Afghanistan

Sustainable Futures
This study explores the impact of supply chain integration, management commitment, and sustainable supply chain practices on the performance of non-profit organizations in Afghanistan.
Sayed Khalid Shahzad, Ilyas Masudin, Fien Zulfikarijah, Tsiqatun Nasyiah, Dian Palupi Restuputri   +4 more
doaj   +1 more source

AI impacts on supply chain performance : a manufacturing use case study. [PDF]

Discov Artif Intell, 2023
Walter S.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The impact of artificial intelligence on sustainable development performance of public healthcare supply chain-an empirical study based on listed Chinese pharmaceutical companies

Frontiers in Public Health
With the continuous deepening of the digital transformation of the public healthcare supply chain, as the next step of digitalization, intelligent transformation has received much attention, especially how artificial intelligence can improve the ...
Qianlan Chen, Ping Long, Ruihai Dong, Chaoling Li, Chaoling Li, Siyi Mao   +5 more
doaj   +1 more source

The Impact of Social Capital on Socially Responsible Supply Chain Performance: The Moderating Role of Supply Chain Transparency. [PDF]

Foods, 2023
Liu H, He G, Ma R, Fu S.
europepmc   +1 more source

Developing supply chain maturity [PDF]

This study introduces an empirical model of supply chain maturity and assesses its impact upon performance. Findings suggest that supply chain maturity is multi-dimensional including the areas of planning, sourcing, making, delivering, new product ...
Done, Adrian
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Innovativeness, visibility, and collaboration effect on supply chain performance: moderating role of digital supply chain integration

Cogent Business & Management
Supply chain capabilities are fundamental in driving superior supply chain performance in diverse business environments. This study evaluates the impact exerted by supply chain capabilities on supply chain performance in the fast-growing apparel ...
M. M. Hussain Shahadat, A. H. M. Yeaseen Chowdhury, Mohammed Abu Jahed, Robert Jeyakumar Nathan, Maria Fekete-Farkas   +4 more
doaj   +1 more source

Net zero supply chain performance and industry 4.0 technologies: Past review and present introspective analysis for future research directions. [PDF]

Heliyon, 2023
El Jaouhari A, Arif J, Samadhiya A, Kumar A.   +3 more
europepmc   +1 more source