A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Digital transformation, smart technologies, and eco-innovation are paving the way toward sustainable supply chain performance. [PDF]
Sci Prog, 2022 Rehman Khan SA +3 more
europepmc +1 more source
Cluster Development and Knowledge Exchange in Supply Chain
, 2008 Industry cluster and supply chain are in focus of every countries which rely on knowledge-based economy. Both focus on improving the competitiveness of firm in the industry in the different aspect.
Bouras, Abdelaziz +3 more
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Social sustainable supply chain performance assessment using hybrid fuzzy-AHP-DEMATEL-VIKOR: a case study in manufacturing enterprises. [PDF]
Environ Dev Sustain, 2022 Guo R, Wu Z.
europepmc +1 more source
THE EFFECT OF GREEN SUPPLY CHAIN MANAGEMENT AND COMPETITIVE ADVANTAGES ON SUSTAINABLE PERFORMANCE OF INDONESIAN SMEs [PDF]
This research was carried out in Malang, Indonesia, focusing on Small and Medium- sized Enterprises (SMEs) and involving a sample of 100 participants.
Hakimi, Abdul Qadir
core
Towards a business model for sustainable supply chain management [PDF]
, 2013 Designers make decisions that ultimately impact on both the economic, environmental and social performance of the products and process, and many of these costs and impacts occur across the supply chain.
Ball, Peter D., Pimenta, Handson
core
Performance optimization of a leagility inspired supply chain model: a CFGTSA algorithm based approach [PDF]
, 2006 Felix T.S. Chan, Vikas Kumar
openalex +1 more source
Performance Measurement in Supply Chain Collaboration
, 2011 Collaboration is an advantageous strategy for technology-based competition. The management of collaboration involves the mutual efforts of supply chain partners to design, implement, and manage seamless value-added processes (Johnson and Johnson 1989).
Çetindamar, Dilek +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source