Results 141 to 150 of about 1,391,443 (312)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Inter-firm Relationships and Performance Factors in the Australian Beef Supply Chain: Implications for the Stakeholders [PDF]

Recent study by Meat & Livestock Australia revealed that cost competitiveness and market development issues in supply chain are the major factors for a long term decline of the Australian Beef industry. This study, based on the explanation of transaction
Islam, Nazrul, Nasir Uddin, Mohammad, Quaddus, Mohammed   +2 more
core   +1 more source

Mediation Effect of Lean: A Bidirectional Synergetic Relationship with SCM for Higher Operational Performance [PDF]

, 2018
Competitive plants focus their efforts on reducing manufacturing costs and waste along their production chains. Hence, manufacturing programs with important practices and methodologies such as lean, JIT, TPM, and Kaizen have been embraced.
Acevedo Amaya, Mario Roberto, Alfalla Luque, Rafaela, Ortega Jiménez, César Humberto   +2 more
core  

A model for green supply chain management in the South African manufacturing sector

Cogent Business & Management
Green supply chain management is growing as a key component of sustainability. Its implementation improves the firms’ supply chain competitiveness and performance.
Roland Louis Epoh, Irvine Langton, Chengedzai Mafini   +2 more
doaj   +1 more source

Influence of supply chain risk management and its mediating role on supply chain performance: perspectives from an agri-fresh produce. [PDF]

Ann Oper Res, 2023
Waqas U, Abd Rahman A, Ismail NW, Kamal Basha N, Umair S.   +4 more
europepmc   +1 more source

Enhancing Supply Chain Transparency in Emerging Economies Using Online Contents and LLMs [PDF]

arXiv
In the current global economy, supply chain transparency plays a pivotal role in ensuring this security by enabling companies to monitor supplier performance and fostering accountability and responsibility. Despite the advancements in supply chain relationship datasets like Bloomberg and FactSet, supply chain transparency remains a significant ...
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Generative Probabilistic Planning for Optimizing Supply Chain Networks [PDF]

arXiv
Supply chain networks in enterprises are typically composed of complex topological graphs involving various types of nodes and edges, accommodating numerous products with considerable demand and supply variability. However, as supply chain networks expand in size and complexity, traditional supply chain planning methods (e.g., those found in heuristic ...
arxiv  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

A simulation-optimization framework for food supply chain network design to ensure food accessibility under uncertainty [PDF]

arXiv
How to ensure accessibility to food and nutrition while food supply chains suffer from demand and supply uncertainties caused by disruptive forces such as the COVID-19 pandemic and natural disasters is an emerging and critical issue. Unstable access to food influences the level of nutrition that weakens the health and well-being of citizens. Therefore,
arxiv