Results 71 to 80 of about 1,458,389 (376)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

How the blockchain enables and constrains supply chain performance

International Journal of Physical Distribution & Logistics Management, 2019
Purpose The purpose of this paper is to understand the enabling and constraining roles of blockchain technology (BCT) in managerial work practices and conceptualise the technology–performance relationship in supply chain management (SCM).
Kim Sundtoft Hald, Aseem Kinra
semanticscholar   +1 more source

Mapping the potentials of blockchain in improving supply chain performance

Cogent Business & Management, 2020
This paper aims at reviewing and systematically mapping research on blockchain potentials in improving supply chain performance. Articles were retrieved from several prominent databases, selected, reviewed, grouped into several themes and synthesized ...
Luh Putu, Richard Mahyuni, Gede Adrian, Sri Darma, Ngakan Nyoman, Kutha Krisnawijaya, Gusti Ayu, A. Dewi, Gusi Putu, Lestara Permana, Luh Putu Mahyuni, Richard Adrian, Gede Sri, Mahyuni, I. Gusti, Ayu Agung, Pradnya Dewi, Gusi Putu Lestara Permana, Agung Pradnya   +18 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Relationship Stability and Supply Chain Performance for SMEs: From Internal, Supplier, and Customer Integration Perspectives

Mathematics, 2020
This study examined the relationship between supply integration and relationship stability and the relationship between relationship stability and performance; furthermore, the moderation effect of environmental uncertainty on supply chain integration ...
Tsu-Ming Yeh, Fan-Yun Pai, Liang-Chuan Wu   +2 more
doaj   +1 more source

The Consequences of Information Technology, Information Sharing and Supply Chain Integration, towards Supply Chain Performance and Firm Performance

Journal of International Logistics and Trade, 2020
This paper presents the concerns in manufacturing supply chain. Further this study investigates the role of information technology (IT) and information sharing (IS) in manufacturing supply chain and determines its impact towards supply chain integration (
V. Sundram, P. Chhetri, A. Bahrin
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Impact of Supply Chain Drivers on Retail Supply Chain Performance [PDF]

The Journal of Social Sciences Research, 2018
Rana, S. S., & Osman, A. B. (2018). Impact of Supply Chain Drivers on Retail Supply Chain Performance. The Journal of Social Sciences Research, 4(10), 176-183.
Abduallh Bin Osman, S M Sohel Rana
openaire   +2 more sources