Results 81 to 90 of about 1,458,389 (376)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Performance measurement in supply chain

AUTOBUSY – Technika, Eksploatacja, Systemy Transportowe, 2018
The article presents performance measurement concept with its application possibility in supply chain management. A practical performance measurement model in supply chains was also presented. Stated model comprises three key areas – transportation, resources and information technology optimization.
Andrzej Krzyszkowski, Piotr Korneta, Magda Chmiel   +2 more
openaire   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Industry 4.0-Enabled Supply Chain Performance: Do Supply Chain Capabilities and Innovation Matter?

Logistics
Background: The present study investigates Industry 4.0’s (I4.0) impact on supply chain capabilities (SCCs), supply chain innovation (SCI), and supply chain performance (SCP). The influence of SCCs and SCI on SCP is also explored.
Ayman Bahjat Abdallah, Hamza Ahmad Almomani, Zu’bi M. F. Al-Zu’bi   +2 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

The Role of Digitalization, Agility, and Capability on Integration and Its Impact on Performance: A Study on the Retail Healthcare Supply Chain in Jakarta

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to examine the impact of digitalization in the supply chain on different elements of supply chain management. Based on the presented research and analysis, it can be concluded that supply chain digitalization positively impacts supply ...
Devina Devina, Wahyuningsih Santosa, Triwulandari Satitidjati Dewayana   +2 more
doaj   +1 more source

Conceptual Framework for Measuring Supply Chain Performance: An Innovative Approach [PDF]

The process of developing appropriate supply chain performance measurement instruments is difficult due to the complexity of supply chains. This paper presents an overview and evaluation of the performance measurement instruments used in supply chain ...
Gellynck, Xavier, Kuhne, Bianka, Molnar, Adrienn   +2 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Enhancing the supply chain performance of Kayumas specialty coffee based on the SCOR-ANP approach

AGROMIX
Introduction: Performance evaluation is essential in defining supply chain strategies because the firm can find out how the business processes in the supply chain are running and formulate strategic policies.
Aisya Risanda, Abdul Wahib Muhaimin, Silvana Maulidah   +2 more
doaj   +1 more source