Results 111 to 120 of about 3,741,726 (317)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Credal Sum-Product Networks

, 2017
Sum-product networks are a relatively new and increasingly popular class of (precise) probabilistic graphical models that allow for marginal inference with polynomial effort. As with other probabilistic models, sum-product networks are often learned from
Decision Support Systems, Cozman, Fabio Gagli, de Campos, Cassio P., Sub Decision Support Systems, Conaty, Diarmaid, Maua, Denis Deratani, de Campos, Casio Polpo   +6 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mobile decision support for triage in emergency departments

, 2004
Triage in emergency departments is often complex and subject to conditions of uncertainty. The need for timely and accurate clinical assessment based on restricted and ambiguous information; the need to be consistent with standard triage scale and the ...
Zaslavsky, Arkady, Pedro, Jocelyn San, San Pedro, Jocelyn, Wassertheil, Jeff, Churilov, Leonid, Cao, Patrick, Burstein, Frada   +6 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

FLEXiT: A platform for estimating residential energy flexibility for aggregated & disaggregated demand-side management

SoftwareX
The large-scale integration of distributed renewable energy sources and electrified end uses increases the need for accurate, scalable assessment of residential demand-side flexibility.
Ioannis Papias, Efstathios Sarantinopoulos, Vasilis Michalakopoulos, Elissaios Sarmas, Vangelis Marinakis   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Building Bayesian networks for legal evidence with narratives: a case study evaluation

, 2014
In a criminal trial, evidence is used to draw conclusions about what happened concerning a supposed crime. Traditionally, the three main approaches to modeling reasoning with evidence are argumentative, narra- tive and probabilistic approaches ...
Sub Intelligent Systems, Prakken, Hendrik, Renooij, S., Intelligent Systems, Sub Decision Support Systems, Vlek, Charlotte s., Renooij, Silja, Vlek, C., Prakken, H., Verheij, B., Verheij, B.; id_orcid, Decision Support Systems, Verheij, Bart   +12 more
core   +1 more source

System Design of an Online Marketplace Towards the Standardisation of Sustainable Energy Efficiency Investments in Buildings

Eng
Nowadays, the increase in sustainable investments, especially when it comes to energy efficiency in buildings, has been recognised as an important pillar towards reductions in energy consumption.
Ioanna Andreoulaki, Aikaterini Papapostolou, Daniela Stoian, Konstantinos Kefalas, Vangelis Marinakis   +4 more
doaj   +1 more source