Results 101 to 110 of about 8,098,927 (284)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Heart failure: The value of evidence-supported decision-making
Revista Portuguesa de Cardiologia, 2020 Dulce Brito
doaj +1 more source
Intelligent Support to Decision Making Process
IFAC Proceedings Volumes, 1987 Abstract Knowledge acquisition is crucial in the design of an expert system, especially the integration of facts and rules that can be heterogeneous. This process of structuring facts and rules is similar to the task of a decision maker evaluating a situation in putting facts together, comparing their utility, arriving at a conclusion about their ...
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Right to Participate in Decision Making: Supported Decision Making in Practice
, 2023 AbstractIdeas about capacity and incapacity have dominated thinking about participation in decision making by people with intellectual disabilities. The United Nations Convention on the Rights of Persons with Disabilities provoked interest in the concept of supported decision making and the rights of all people with disabilities to be involved in ...
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Supported Decision-Making: Good Practice Guide
, 2016 Supported decision-making maximizes an individual's ability to ensure that their rights, will and preferences are at the centre of all decisions that concern them..
Stavert, Jill
core
Decision-making Competence, Executive Functioning, and General Cognitive Abilities
, 2011 Although previous studies investigated the relationship between general cognitive abilities and decision making, few have characterized specific cognitive abilities underlying decision-making competence.
Mäntylä, Timo, +7 more
core +1 more source