Results 181 to 190 of about 314,869 (336)

"I Felt Supported by the Peers in My Group": Analyzing Experiences of Youths with Mental Health Challenges of a Supported Employment Program in Canada. [PDF]

J Occup Rehabil, 2022
Ow N, Leon A, Thom B, Herwynen J, Mathias SM, Barbic S.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Work re-entry and functioning in people with major depression: a longitudinal study of supported employment participants. [PDF]

BMC Psychiatry
Bergdolt J, Hubert S, Schreiter J, Jenderny S, Beblo T, Driessen M, Steinhart I, Dehn LB.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

An RCT of Virtual Reality Job Interview Training for Individuals With Serious Mental Illness in IPS Supported Employment. [PDF]

Psychiatr Serv, 2022
Smith MJ, Smith JD, Blajeski S, Ross B, Jordan N, Bell MD, McGurk SR, Mueser KT, Burke-Miller JK, Oulvey EA, Fleming MF, Nelson K, Brown A, Prestipino J, Pashka NJ, Razzano LA.   +15 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Implementing Supported Employment in the Norwegian Labor and Welfare Administration - Experiences from employment specialists and critical implementation issues. [PDF]

Work
Schönfelder W, Arntzen C, Johansen T.
europepmc   +1 more source

Hybrid Supported Employment Approach for Persons with Intellectual Disabilities in India: Evidence Based Case Studies. [PDF]

J Psychosoc Rehabil Ment Health, 2022
Chandrasekaran P, Thekkumkara SN, Jothibalan A, Jagannathan A, Jayarajan D, Reddy SK.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Enhancing individual task performance and productivity: an ethnographic observational study of supported employment among social services clients in Finland. [PDF]

BMC Public Health
Juvonen-Posti P, Vuorento M.
europepmc   +1 more source