Results 81 to 90 of about 4,637,377 (303)

Early versus delayed palliative/supportive care in advanced cancer: An observational study

, 2020
Objective: The positive impact of early palliative care interventions in advanced cancer patients has so far been largely evaluated in randomised controlled trials.
Artioli F., D'Amico R., Efficace F., Bandieri E., Razzini G., Banchelli F., Bruera E., Luppi M., Potenza L., Cruciani M., Mucciarini C.   +10 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Early palliative care in metastatic uveal melanoma (early together): protocol of a prospective randomized Phase III trial

Melanoma Management
Metastatic uveal melanoma (UM) patients often initially present with limited symptoms despite a poor prognosis, complicating communication with patients and caregivers.
Sophie Piperno-Neumann, Leanne de Koning, Timothée Marchal, Lauris Gastaud, Lorraine Waechter, Anne Fogliarini, Carole Bouleuc, Yves Libert, Romain Seban, Laura Marret, Agnes Ducoulombier, Manuel Rodrigues, Anne Bredart, Alexia Savignoni, Sylvie Dolbeault, Alexis Burnod   +15 more
doaj   +1 more source

Quality of life in head and neck cancer survivors at 1 year after treatment: the mediating role of unmet supportive care needs

, 2014
© 2014, Springer-Verlag Berlin Heidelberg. Results: The final path model showed that optimism, educational level, any coexisting disease, number of somatic symptoms, household income, eating ability, support from others, whether the cancer is under ...
Ling, W. M., Yu, Bernice W.L., Wan, Rayman W.M., Chair, S. Y., Ng, W. T., So, Winnie K.W., Mak, Suzanne S.S., Chan, Carmen W.H., Choi, K. C., Chen, Joanne M.T., Fung, Olivia W.M.   +10 more
core   +1 more source

Long-term unmet supportive care needs of prostate cancer survivors: 15-year follow-up from the NSW Prostate Cancer Care and Outcomes Study

, 2020
Purpose: To determine the prevalence, severity, and baseline associations of self-reported long-term unmet supportive care needs in a population-wide cohort of men with prostate cancer (PC), 15 years post-diagnosis.
Mazariego, CG, Juraskova, I, Smith, DP, Campbell, R   +3 more
core   +1 more source

The influence of care place and diagnosis on care communication at the end of life : bereaved family members' perspective

, 2021
OBJECTIVE: To investigate the influence of care place and diagnosis on care communication during the last 3 months of life for people with advanced illness, from the bereaved family members' perspective.METHOD: A retrospective survey design using the ...
Alvariza, Anette, Alvariza, Anette,, O'Sullivan, Anna, O'Sullivan, A., Ex. Håkanson, C. L., Öhlén, Joakim,, Larsdotter, Cecilia,, Larsdotter ex. Håkanson, Cecilia,, Alvariza, A., O'Sullivan, Anna,, Öhlén, Joakim   +10 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Psychopharmacology in supportive care of cancer: a review for the clinician. IV. Other psychotropic agents

, 2001
Besides benzodiazepine, antidepressant and neuroleptic agents, all of which have established roles in supportive care, other psychotropic drugs deserve consideration in selected conditions affecting patients with advanced cancer.
Buclin, T., Mazzocato, C., Stiefel, F., Berney, A.   +3 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source