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Genetic Strategies of Tumor Suppression
American Review of Respiratory Disease, 1990The evaluation of the cancer cell is a complex multigene process. Tumor suppressor genes that are lost or inactivated, as well as genes that are overexpressed, play key roles in tumor progression. The identification of overexpressed genes has been expedited by the presence of transforming genes in some animal retroviruses.
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Genetic regulation of testosterone-induced immune suppression
Cellular Immunology, 1987Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains
S A, Ahmed, N, Talal, P, Christadoss
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The genetics of tumor suppression by p53
The FASEB Journal, 2022Mutational inactivation of TP5 3 occurs commonly in cancer. In addition to mutation, there are over two hundred germline genetic variants in the TP5 3 coding region; some of these produce partially functional (hypomorphic) protein.
Maureen Murphy +9 more
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Genetic studies on temperature sensitive nonsense suppression
Molecular and General Genetics MGG, 1970Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures.
E, Gallucci, G, Pacchetti, S, Zangrossi
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Nonsense suppression therapies in ocular genetic diseases
Cellular and Molecular Life Sciences, 2015Premature termination codons (PTCs) are caused by nonsense mutations and this leads to either degradation of the mutant mRNA template by nonsense-mediated decay (NMD) or the production of a non-functional, truncated polypeptide. PTCs contribute significantly to inherited human diseases including ocular disorders.
Xia, Wang, Cheryl Y, Gregory-Evans
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Genetic Suppression of Tumor Formation
1985Publisher Summary Genomic changes of all kinds, ranging from base substitutions, deletions, duplications, amplifications, and rearrangements, are characteristic of malignant cells. With respect to genetic suppression of tumor formation, genomic changes can play a crucial role in eliminating or silencing suppressor genes during tumorigenesis.
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A global genetic suppression network
Science, 2016Yeast Genetics The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set
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Genetic Suppression of Polyglutamine Toxicity in Drosophila
Science, 2000A Drosophila model for Huntington's and other polyglutamine diseases was used to screen for genetic factors modifying the degeneration caused by expression of polyglutamine in the eye. Among 7000 P-element insertions, several suppressor strains were isolated, two of which led to the discovery of the suppressor genes
Kazemi-Esfarjani, Parsa, Benzer, Seymour
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Genetically restricted antigen presentation for immunological tolerance and suppression
Nature, 1984The activation of some subsets of T cells requires the recognition of antigen in association with self Ia determinants. It is not clear, however, whether this is also necessary for the induction of unresponsiveness and the active suppression of hapten-specific T cells.
A, Lowy +4 more
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Genetic suppression of malignancy.
IARC scientific publications, 1989Genetic tumours of Xiphophorus are one of the classical experimental models that underline the concept that cancers develop as a result of abnormal gene expression. Formal genetics has indicated that cancer development in Xiphophorus starts when oncogenes are expressed abnormally due to elimination of tumour suppressor genes.
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