Results 51 to 60 of about 418,345 (265)
Abnormal contextual modulation of visual contour detection in patients with schizophrenia.
PLoS ONE, 2013 Schizophrenia patients demonstrate perceptual deficits consistent with broad dysfunction in visual context processing. These include poor integration of segments forming visual contours, and reduced visual contrast effects (e.g.
Michael-Paul Schallmo +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
SAR Waveform Diversity Using PN-Sequence and Its Optimization With Genetic Algorithm
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingWaveform diversity is an important technique to suppress range ambiguities and extend the observation coverage of synthetic aperture radar (SAR) without sacrificing spatial resolution and power consumption.
Raito Suzuki, Akira Hirose, Ryo Natsuaki
doaj +1 more source
Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.
PLoS Genetics, 2012 Chromatin-modifying enzymes and ATP-dependent remodeling complexes have been intensely studied individually, yet how these activities are coordinated to ensure essential cell functions such as transcription, replication, and repair of damage is not well ...
Anne Lafon, Emily Petty, Lorraine Pillus
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Results and possible prospects of genetic technology in ophthalmology (literature review). Part I
Journal of Ophthalmology, 2021 The emergence of fundamentally novel technological solutions in the field of gene therapy today, the formation of the priority and the development of genetic technologies create serious prerequisites for the beginning of a new Fusion era in ophthalmology
N. A. Gavrilova +2 more
doaj +1 more source
Suppression of pattern-forming instabilities by genetic optimization
Physical Review E, 2016 We propose a versatile "stabilization on demand" method for the suppression of modulation instability in oscillatory spatially extended nonlinear systems, based on a genetically optimized multifrequency spatiotemporal modulation of the potential. The method, which ensures full stabilization even for very strong nonlinearities, forms a powerful tool ...
Kumar, Shubham +3 more
openaire +4 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular genetic approaches to the targeted suppression of neuronal activity [PDF]
Current Biology, 2001 Understanding how the diverse cells of the nervous system generate sensations, memories and behaviors is a profound challenge. This is because the activity of most neurons cannot easily be monitored or individually manipulated in vivo. As a result, it has been difficult to determine how different neurons contribute to nervous system function, even in ...
White, Benjamin +2 more
openaire +2 more sources