Results 31 to 40 of about 424,245 (266)

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. [PDF]

PLoS ONE, 2013
The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being investigated as therapeutic agents ...
Laura E Crotty Alexander, Brenda J Marsh, Anjuli M Timmer, Ann E Lin, Kayvan Zainabadi, Agnieszka Czopik, Leonard Guarente, Victor Nizet   +7 more
doaj   +1 more source

Exploring genetic suppression interactions on a global scale [PDF]

Science, 2016
A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen
Jolanda, van Leeuwen, Carles, Pons, Joseph C, Mellor, Takafumi N, Yamaguchi, Helena, Friesen, John, Koschwanez, Mojca Mattiazzi, Ušaj, Maria, Pechlaner, Mehmet, Takar, Matej, Ušaj, Benjamin, VanderSluis, Kerry, Andrusiak, Pritpal, Bansal, Anastasia, Baryshnikova, Claire E, Boone, Jessica, Cao, Atina, Cote, Marinella, Gebbia, Gene, Horecka, Ira, Horecka, Elena, Kuzmin, Nicole, Legro, Wendy, Liang, Natascha, van Lieshout, Margaret, McNee, Bryan-Joseph, San Luis, Fatemeh, Shaeri, Ermira, Shuteriqi, Song, Sun, Lu, Yang, Ji-Young, Youn, Michael, Yuen, Michael, Costanzo, Anne-Claude, Gingras, Patrick, Aloy, Chris, Oostenbrink, Andrew, Murray, Todd R, Graham, Chad L, Myers, Brenda J, Andrews, Frederick P, Roth, Charles, Boone   +41 more
openaire   +2 more sources

Recoding of Nonsense Mutation as a Pharmacological Strategy

Biomedicines, 2023
Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj, Pelin Telkoparan-Akillilar, Nexhibe Nuhii, Silvia Chichiarelli, Sarmistha Saha, Luciano Saso   +5 more
doaj   +1 more source

Literature Review of Optimization Technique for Chatter Suppression in Machining [PDF]

Journal of Mechanical Engineering and Sciences, 2011
Chatter produces a poor surface finish, high tool wear, and can even damage machine tools because of the regenerative effect, the loss of contact effect, and the mode coupling effect. Various research works have investigated the suppression of chatter by
Ahmad Razlan Yusoff , Mohamed Reza Zalani Mohamed Suffian , Mohd Yusof Taib   +2 more
doaj   +1 more source

Cell suppression problem: A genetic-based approach

Computers & Operations Research, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Maria Teresa Almeida, Gabriela Schütz, Filipa Duarte de Carvalho   +2 more
openaire   +3 more sources

Genetic variation of copia suppression in Drosophila melanogaster [PDF]

Heredity, 2010
Transposable elements (TEs) are genomic parasites that propagate by exploiting its host reproductive machinery. However, some hosts have evolved the ability to silence TE activity, whereas others have not. We are investigating the population dynamics of TE host-silencing pathways, particularly copia long terminal repeat retrotransposon in Drosophila ...
W, Vu, S, Nuzhdin
openaire   +2 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

HIV controllers: hope for a functional cure

Frontiers in Immunology
Elite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying ...
Zhuoya Deng, Zhuoya Deng, Hongxia Yan, Hongxia Yan, Olivier Lambotte, Christiane Moog, Christiane Moog, Bin Su, Bin Su, Bin Su   +9 more
doaj   +1 more source

Expressive suppression in psychosis: The association with social context.

PLoS ONE, 2020
As emotion regulation deficits have been implicated in psychotic disorders, it is imperative to investigate not only the effect of regulation strategies but also how they are used.
UnYoung Chavez-Baldini, Marieke Wichers, Ulrich Reininghaus, Johanna T W Wigman, Genetic Risk and Outcome of Psychosis Investigators   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source