Results 11 to 20 of about 418,345 (265)

Hypervariability, suppressed recombination and the genetics of individuality [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
We define ‘genetic individuality’ as intraspecies variation that has substantial heritability and involves traits that are sufficiently common that they can be observed in any modest–sized sampling of individuals. We propose that genetic individuality is largely shaped by the combinatory shuffling of a modest number of genes, each of which exists as a ...
M V, Olson, A, Kas, K, Bubb, R, Qui, E E, Smith, C K, Raymond, R, Kaul   +6 more
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Mechanisms of suppression: The wiring of genetic resilience [PDF]

BioEssays, 2017
Recent analysis of genome sequences has identified individuals that are healthy despite carrying severe disease‐associated mutations. A possible explanation is that these individuals carry a second genomic perturbation that can compensate for the detrimental effects of the disease allele, a phenomenon referred to as suppression.
Jolanda, van Leeuwen, Carles, Pons, Charles, Boone, Brenda J, Andrews   +3 more
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Systematic analysis of bypass suppression of essential genes

Molecular Systems Biology, 2020
Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were ...
Jolanda van Leeuwen, Carles Pons, Guihong Tan, Jason Zi Wang, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Maykel Lopes, Matej Ušaj, Andreia Dos Santos Lopes, Natascha van Lieshout, Chad L Myers, Frederick P Roth, Patrick Aloy, Brenda J Andrews, Charles Boone   +18 more
doaj   +1 more source

Transgenic Suppression of AGAMOUS Genes in Apple Reduces Fertility and Increases Floral Attractiveness. [PDF]

PLoS ONE, 2016
We investigated the ability of RNA interference (RNAi) directed against two co-orthologs of AGAMOUS (AG) from Malus domestica (domestic apple, MdAG) to reduce the risks of invasiveness and provide genetic containment of transgenes, while also promoting ...
Amy L Klocko, Ewa Borejsza-Wysocka, Amy M Brunner, Olga Shevchenko, Herb Aldwinckle, Steven H Strauss   +5 more
doaj   +1 more source

Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. [PDF]

PLoS ONE, 2009
BACKGROUND:Growth and division of Saccharomyces cerevisiae is dependent on the action of SNARE proteins that are required for membrane fusion. SNAREs are regulated, through a poorly understood mechanism, to ensure membrane fusion at the correct time and ...
Daniel C Williams, Peter J Novick
doaj   +1 more source

Genetic suppression [PDF]

WormBook, 2005
Genetic suppression has provided a very powerful tool for analyzing C. elegans. Suppression experiments are facilitated by the ability to handle very large numbers of individuals and to apply powerful selections. Because the animal grows as a self-fertilizing diploid, both dominant and recessive suppressors can be recovered.
openaire   +2 more sources

Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy. [PDF]

PLoS ONE, 2012
BackgroundGood adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, some patients remain virologically suppressed despite suboptimal adherence.
Tracy R Glass, Margalida Rotger, Amalio Telenti, Laurent Decosterd, Chantal Csajka, Heiner C Bucher, Huldrych F Günthard, Martin Rickenbach, Dunja Nicca, Bernard Hirschel, Enos Bernasconi, Gilles Wandeler, Manuel Battegay, Catia Marzolini, Swiss HIV Cohort Study   +14 more
doaj   +1 more source

Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2016
The concept of "protein-based inheritance" defines prions as epigenetic determinants that cause several heritable traits in eukaryotic microorganisms, such as Saccharomyces cerevisiae and Podospora anserina.
Anton A Nizhnikov, Tatyana A Ryzhova, Kirill V Volkov, Sergey P Zadorsky, Julia V Sopova, Sergey G Inge-Vechtomov, Alexey P Galkin   +6 more
doaj   +1 more source

Genetic suppression of cryoprotectant toxicity

Cryobiology, 2019
We report here a new, unbiased forward genetic method that uses transposon-mediated mutagenesis to enable the identification of mutations that confer cryoprotectant toxicity resistance (CTR). Our method is to select for resistance to the toxic effects of M22, a much-studied whole-organ vitrification solution.
James R, Cypser, Wallace S, Chick, Gregory M, Fahy, Garrett J, Schumacher, Thomas E, Johnson   +4 more
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A grating lobe suppression method for displaced subarrays using genetic algorithm

IET Microwaves, Antennas & Propagation, 2022
The large‐element‐spacing array is often used to reduce the channels and costs of the phased array. However, it will form grating lobes (GLs) in the visible space, which decrease the performance. The displaced subarray technique has strong GL suppression
Lei Yang, Kan Wang, Hongbing Sun
doaj   +1 more source