Results 21 to 30 of about 418,345 (265)

Efficient targeted recombination with CRISPR/Cas9 in hybrids of Caenorhabditis nematodes with suppressed recombination

BMC Biology, 2023
Background Homology-based recombination (HR) is the cornerstone of genetic mapping. However, a lack of sufficient sequence homology or the presence of a genomic rearrangement prevents HR through crossing, which inhibits genetic mapping in relevant ...
Dongying Xie, Bida Gu, Yiqing Liu, Pohao Ye, Yiming Ma, Tongshu Wen, Xiaoyuan Song, Zhongying Zhao   +7 more
doaj   +1 more source

Waveband specific transcriptional control of select genetic pathways in vertebrate skin (Xiphophorus maculatus)

BMC Genomics, 2018
Background Evolution occurred exclusively under the full spectrum of sunlight. Conscription of narrow regions of the solar spectrum by specific photoreceptors suggests a common strategy for regulation of genetic pathways.
Ronald B. Walter, Mikki Boswell, Jordan Chang, William T. Boswell, Yuan Lu, Kaela Navarro, Sean M. Walter, Dylan J. Walter, Raquel Salinas, Markita Savage   +9 more
doaj   +1 more source

Genetic identification of a neural circuit that suppresses appetite [PDF]

Nature, 2013
Appetite suppression occurs after a meal and in conditions when it is unfavourable to eat, such as during illness or exposure to toxins. A brain region proposed to play a role in appetite suppression is the parabrachial nucleus, a heterogeneous population of neurons surrounding the superior cerebellar peduncle in the brainstem. The parabrachial nucleus
Carter, Matthew E., Soden, Marta E., Zweifel, Larry S., Palmiter, Richard D.   +3 more
openaire   +2 more sources

Engineered transfer RNAs for suppression of premature termination codons

Nature Communications, 2019
Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.
John D. Lueck, Jae Seok Yoon, Alfredo Perales-Puchalt, Adam L. Mackey, Daniel T. Infield, Mark A. Behlke, Marshall R. Pope, David B. Weiner, William R. Skach, Paul B. McCray, Christopher A. Ahern   +10 more
doaj   +1 more source

Dataset of SSR markers for ISSR-Suppression-PCR to detect genetic variation in Garcinia mangostana L. in Peninsular Malaysia

Data in Brief, 2016
In this dataset, we present 15 Simple Sequence Repeat (SSR) markers with the motifs (AC)n, (GA)n, and (AC)n(AG)n using a ISSR-Suppression-PCR technique in order to discriminate Garcinia mangostana from diverse geographical origins in Peninsular Malaysia.
Sri A’jilah Samsir, Hamidun Bunawan, Choong Chee Yen, Normah Mohd Noor   +3 more
doaj   +1 more source

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons

Molecular Medicine, 2018
Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins.
Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz   +2 more
doaj   +1 more source

Rescue by gene swamping as a gene drive deployment strategy

Cell Reports, 2023
Summary: Gene drives are genetic constructs that can spread deleterious alleles with potential application to population suppression of harmful species. As gene drives can potentially spill over to other populations or species, control measures and fail ...
Keith D. Harris, Gili Greenbaum
doaj   +1 more source

Exploring genetic suppression interactions on a global scale [PDF]

Science, 2016
A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen
Jolanda, van Leeuwen, Carles, Pons, Joseph C, Mellor, Takafumi N, Yamaguchi, Helena, Friesen, John, Koschwanez, Mojca Mattiazzi, Ušaj, Maria, Pechlaner, Mehmet, Takar, Matej, Ušaj, Benjamin, VanderSluis, Kerry, Andrusiak, Pritpal, Bansal, Anastasia, Baryshnikova, Claire E, Boone, Jessica, Cao, Atina, Cote, Marinella, Gebbia, Gene, Horecka, Ira, Horecka, Elena, Kuzmin, Nicole, Legro, Wendy, Liang, Natascha, van Lieshout, Margaret, McNee, Bryan-Joseph, San Luis, Fatemeh, Shaeri, Ermira, Shuteriqi, Song, Sun, Lu, Yang, Ji-Young, Youn, Michael, Yuen, Michael, Costanzo, Anne-Claude, Gingras, Patrick, Aloy, Chris, Oostenbrink, Andrew, Murray, Todd R, Graham, Chad L, Myers, Brenda J, Andrews, Frederick P, Roth, Charles, Boone   +41 more
openaire   +2 more sources

Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.

PLoS Genetics, 2020
Cryptic genetic variation could arise from, for example, Gene-by-Gene (G-by-G) or Gene-by-Environment (G-by-E) interactions. The underlying molecular mechanisms and how they influence allelic effects and the genetic variance of complex traits is largely ...
Yanjun Zan, Örjan Carlborg
doaj   +1 more source

Genetic Algorithm Based Prototype Filter Design for Oriented Side Lobe Energy Suppression in FBMC System

IEEE Access, 2020
The prototype filter design problem is investigated for the filter bank multicarrier (FBMC) system of the fifth generation (5G) physical-layer wireless communications.
Junhui Zhao, Siying Lv, Lihua Yang, Shanjin Ni   +3 more
doaj   +1 more source