The genomic landscape of compensatory evolution. [PDF]
PLoS Biology, 2014 Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects ...
Béla Szamecz +13 more
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Genomics, Transcriptomics, and Metabolomics Reveal That Minimal Modifications in the Host Are Crucial for the Compensatory Evolution of ColE1-Like Plasmids [PDF]
mSphere, 2022 Plasmid-mediated antimicrobial resistance is one of the major threats to public health worldwide. The mechanisms involved in the plasmid/host coadaptation are still poorly characterized, and their understanding is crucial to comprehend the genesis and ...
Manuel Ares-Arroyo +7 more
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Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost [PDF]
Ecology and EvolutionPlasmids incur a fitness cost that has the potential to restrict the dissemination of resistance in bacterial pathogens. However, bacteria can overcome this disadvantage by compensatory evolution to maintain their resistance.
Ziyi Liu +3 more
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Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia [PDF]
eLife, 2018 Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear. We utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence
Matthias Merker +14 more
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Global genetic rewiring during compensatory evolution in the yeast polarity network [PDF]
EMBO ReportsFunctional defects resulting from deleterious mutations can often be restored during evolution by compensatory mutations. Importantly, this process can generate the genetic diversity seen in networks regulating the same biological function in different ...
Enzo Kingma +3 more
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Modular epistasis and the compensatory evolution of gene deletion mutants. [PDF]
PLoS Genetics, 2019 Screens for epistatic interactions have long been used to characterize functional relationships corresponding to protein complexes, metabolic pathways, and other functional modules.
José I Rojas Echenique +3 more
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Compensatory evolution to DNA replication stress is robust to nutrient availability [PDF]
Molecular Systems BiologyEvolutionary repair refers to the compensatory evolution that follows perturbations in cellular processes. While evolutionary trajectories are often reproducible, other studies suggest they are shaped by genotype-by-environment (GxE) interactions.
Mariana Natalino, Marco Fumasoni
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Compensatory evolution of net-charge in influenza A virus hemagglutinin. [PDF]
PLoS ONE, 2012 The propagation of influenza A virus depends on the balance between the activities of hemagglutinin (HA) for binding to host cells and neuraminidase (NA) for releasing from infected cells (HA-NA balance).
Yuki Kobayashi, Yoshiyuki Suzuki
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Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers [PDF]
Cell Reports, 2015 Many developmental genes are controlled by shadow enhancers—pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene, while individual shadow enhancers diverge ...
Zeba Wunderlich +5 more
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Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution [PDF]
Antibiotics, 2013 Seventy years after the introduction of antibiotic chemotherapy to treat tuberculosis, problems caused by drug-resistance in Mycobacterium tuberculosis have become greater than ever.
Gerrit Brandis, Diarmaid Hughes
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