The fitness cost of spurious phosphorylation [PDF]
The EMBO Journal, 2023 The fidelity of signal transduction requires the binding of regulatory molecules to their cognate targets. However, the crowded cell interior risks off-target interactions between proteins that are functionally unrelated. How such off-target interactions
David Bradley +8 more
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Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening
Feifei Tang +9 more
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The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids [PDF]
mBio, 2022 By providing the bacterial cell with protection against several antibiotics at once, multiresistance plasmids have an evolutionary advantage in situations where antibiotic treatments are common, such as in hospital environments.
Fredrika Rajer, Linus Sandegren
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Fitness cost of reassortment in human influenza. [PDF]
PLoS Pathogens, 2017 Reassortment, which is the exchange of genome sequence between viruses co-infecting a host cell, plays an important role in the evolution of segmented viruses.
Mara Villa, Michael Lässig
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Genomic features and fitness cost of co-existence of blaKPC-2 and blaVIM-2 plasmids in ICU-derived pan-drug resistant Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroudThe emergence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) co-producing KPC-2 and VIM-2 has increased the healthcare threats.ResultsIn this study, a CRPA strain 18102011, was isolated from the bile of a burn patient in ICU of China. Its
Lin Zheng +10 more
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Fitness Cost of the Field-Evolved Resistance to Sulfoxaflor and Multi-Insecticide Resistance of the Wheat Aphid Sitobion miscanthi (Takahashi) [PDF]
Insects, 2023 Sulfoxaflor belongs to a new class of insecticides that is effective against many sap-feeding pests. In this study on Sitobion miscanthi (Takahashi) (i.e., the predominant wheat pest), a highly sulfoxaflor-resistant (SulR) population was obtained from a ...
Xinan Li +10 more
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Mycobacterium tuberculosis: mechanisms and interactions between drug resistance mutations with fitness costs and the drug resistance phenotypes [PDF]
Infectious Diseases and Tropical Medicine, 2022 Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis are no news and have contributed to the continued scourge of tuberculosis today. Acquisition of drug resistance by M.
R. Olamilekan Adesola +1 more
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Diet can alter the cost of resistance to a natural parasite in Caenorhabditis elegans
Ecology and Evolution, 2023 Resistance to parasites confers a fitness advantage, yet hosts show substantial variation in resistance in natural populations. Evolutionary theory indicates that resistant and susceptible genotypes can coexist if resistance is costly, but there is mixed
Juliana Jiranek, Amanda Gibson
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Frontiers in Microbiology, 2022 Pseudomonas aeruginosa (P. aeruginosa), a common cause of severe chronic infections, has developed heteroresistance to several antibiotics, thus hindering successful treatment.
Wen-Ru Li +7 more
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Frontiers in Veterinary Science, 2022 Macrolides are widely used in diseases caused by Mycoplasma spp. The new semi-synthetic macrolide antibiotic tulathromycin is currently in wide use for the treatment of respiratory diseases of livestock.
Xirui Xia +4 more
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