The fitness cost of spurious phosphorylation [PDF]
The EMBO Journal, 2023 The fidelity of signal transduction requires the binding of regulatory molecules to their cognate targets. However, the crowded cell interior risks off-target interactions between proteins that are functionally unrelated. How such off-target interactions
David Bradley +8 more
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Fitness cost of reassortment in human influenza. [PDF]
PLoS Pathogens, 2017 Reassortment, which is the exchange of genome sequence between viruses co-infecting a host cell, plays an important role in the evolution of segmented viruses.
Mara Villa, Michael Lässig
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Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Tigecycline is one of important antimicrobial agents for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, the emergence and prevalence of plasmid-mediated tigecycline resistance gene tet(X4) are threatening
Feifei Tang +9 more
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Fitness Cost of the Field-Evolved Resistance to Sulfoxaflor and Multi-Insecticide Resistance of the Wheat Aphid Sitobion miscanthi (Takahashi) [PDF]
Insects, 2023 Sulfoxaflor belongs to a new class of insecticides that is effective against many sap-feeding pests. In this study on Sitobion miscanthi (Takahashi) (i.e., the predominant wheat pest), a highly sulfoxaflor-resistant (SulR) population was obtained from a ...
Xinan Li +10 more
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Cost-Effectiveness of Physical Fitness Training for Stroke Survivors [PDF]
Journal of the Royal College of Physicians of Edinburgh, 2018 Background Physical fitness is impaired after stroke, yet fitness training after stroke reduces disability. Several international guidelines recommend that fitness training be incorporated as part of stroke rehabilitation. However, information about cost-effectiveness is limited. Methods A decision tree model was used to estimate the cost-effectiveness
Collins, M +3 more
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Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in Plasmodium falciparum parasites [PDF]
mBioReduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in other genes, like ubp1.
Hannah M. Behrens +8 more
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The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids [PDF]
mBio, 2022 By providing the bacterial cell with protection against several antibiotics at once, multiresistance plasmids have an evolutionary advantage in situations where antibiotic treatments are common, such as in hospital environments.
Fredrika Rajer, Linus Sandegren
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Fitness Cost Evolution of Natural Plasmids of Staphylococcus aureus
mBio, 2021 Plasmids are major agents in the spread of antibiotic resistance genes among bacteria. How plasmids and their hosts coevolve to reduce the fitness cost associated with plasmid carriage when bacteria grow in an antibiotic-free environment is not well understood.
Pedro Dorado-Morales +3 more
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Dissecting the Fitness Costs of Complex Mutations [PDF]
Molecular Biology and Evolution, 2021 Abstract The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one hand, it is necessary to identify which molecular properties are directly altered by the mutation. On the other, this alteration modifies the activity of many genetic targets with uncertain consequences.
Pablo Yubero, Juan F Poyatos
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Diet can alter the cost of resistance to a natural parasite in Caenorhabditis elegans
Ecology and Evolution, 2023 Resistance to parasites confers a fitness advantage, yet hosts show substantial variation in resistance in natural populations. Evolutionary theory indicates that resistant and susceptible genotypes can coexist if resistance is costly, but there is mixed
Juliana Jiranek, Amanda Gibson
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