Results 1 to 10 of about 30,353 (249)

Development of a Novel mcr-6 to mcr-9 Multiplex PCR and Assessment of mcr-1 to mcr-9 Occurrence in Colistin-Resistant Salmonella enterica Isolates From Environment, Feed, Animals and Food (2011–2018) in Germany

Frontiers in Microbiology, 2020
The polymyxin antibiotic colistin has been used in decades for treatment and prevention of infectious diseases in livestock. Nowadays, it is even considered as last-line treatment option for severe human infections caused by multidrug- and carbapenem ...
Carlus Deneke, Burkhard Malorny, Jens André Hammerl   +2 more
exaly   +3 more sources

Deciphering MCR-2 Colistin Resistance

MBio, 2017
Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria.
Xing-Ping Li, Youjun Feng, Yongchang Xu   +2 more
exaly   +3 more sources

Characterization of two novel colistin resistance gene mcr-1 variants originated from Moraxella spp.

Frontiers in Microbiology, 2023
This study aimed to characterize two novel mcr-1 variants, mcr-1.35 and mcr-1.36, which originated from Moraxella spp. that were isolated from diseased pigs in China. The Moraxella spp.
Yongliang Che, Yongliang Che, Renjie Wu, Renjie Wu, Hongjie Li, Longbai Wang, Longbai Wang, Xuemin Wu, Xuemin Wu, Qiuyong Chen, Qiuyong Chen, Rujing Chen, Rujing Chen, Lunjiang Zhou, Lunjiang Zhou   +14 more
doaj   +1 more source

MCR Expression Conferring Varied Fitness Costs on Host Bacteria and Affecting Bacteria Virulence

Antibiotics, 2021
Since the first report of the plasmid-mediated, colistin-resistant gene, mcr-1, nine mcr genes and their subvariants have been identified. The spreading scope of mcr-1~10 varies greatly, suggesting that mcr-1~10 may have different evolutionary advantages.
Wan Li, Zhihai Liu, Wenjuan Yin, Lu Yang, Lu Qiao, Shikai Song, Zhuoren Ling, Ruicheng Zheng, Congming Wu, Yang Wang, Jianzhong Shen   +10 more
doaj   +1 more source

Effect of Different Tolerable Levels of Constitutive mcr-1 Expression on Escherichia coli

Microbiology Spectrum, 2022
To study the effect of different tolerable levels of constitutive mcr-1 expression on Escherichia coli, and to provide direct evidence for moderate resistance mediated by mcr-1, construction of E.
Han Qiao, Jie Yu, Xiukun Wang, Tongying Nie, Xinxin Hu, Xinyi Yang, Congran Li, Xuefu You   +7 more
doaj   +1 more source

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. [PDF]

PLoS ONE, 2018
A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes.
Mark G Wise, Mark A Estabrook, Daniel F Sahm, Gregory G Stone, Krystyna M Kazmierczak   +4 more
doaj   +1 more source

Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China

Microbiology Spectrum, 2023
Colistin is one of the last-resort antibiotics for treating infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, mcr genes conferring resistance to colistin have been widely identified, which is considered a global threat to ...
Xiaoyu Lu, Pei Zhang, Pengcheng Du, Xiuli Zhang, Juan Wang, Yingying Yang, Honghu Sun, Zhiqiang Wang, Shenghui Cui, Ruichao Li, Li Bai   +10 more
doaj   +1 more source

One Health Analysis of mcr-Carrying Plasmids and Emergence of mcr-10.1 in Three Species of Klebsiella Recovered from Humans in China

Microbiology Spectrum, 2022
The global dissemination of the mobile colistin resistance (mcr) gene illustrates how the use of colistin in veterinary medicine can affect human health, exemplifying the concept of One Health.
Melissa Chunjiao Liu, Zijuan Jian, Wenen Liu, Junhua Li, Na Pei   +4 more
doaj   +1 more source

Characterization of a mcr-1 and CRISPR-Cas System Co-harboring Plasmid in a Carbapenemase-Producing High-Risk ST11 Klebsiella pneumoniae Strain

Frontiers in Microbiology, 2021
We set out to study the prevalence of the mcr-1 gene in carbapenemase-producing Klebsiella pneumoniae (CPKP) strains, and to determine whether its presence is associated with a fitness cost.
Yi-Hsiang Cheng, Yi-Hsiang Cheng, Sheng-Hua Chou, Po-Han Huang, Tsuey-Ching Yang, Yu-Fan Juan, Barry N. Kreiswirth, Yi-Tsung Lin, Yi-Tsung Lin, Liang Chen, Liang Chen   +10 more
doaj   +1 more source

Chromosomally and Plasmid-Located mcr in Salmonella from Animals and Food Products in China

Microbiology Spectrum, 2022
This study aimed to investigate the prevalence and genomic characteristics of the colistin resistance gene mcr in Salmonella enterica in China. In total, 445 S. enterica isolates from animals and food products were screened through PCR and sequencing for
Cai-Yue Mei, Yue Jiang, Qin-Chun Ma, Meng-Jun Lu, Han Wu, Zhen-Yu Wang, Xinan Jiao, Jing Wang   +7 more
doaj   +1 more source