Results 1 to 10 of about 36,778 (291)

Remarkable Diversity of Escherichia coli Carrying mcr-1 from Hospital Sewage with the Identification of Two New mcr-1 Variants [PDF]

Frontiers in Microbiology, 2017
The plasmid-borne colistin-resistant gene mcr-1 has rapidly become a worldwide public health concern. This study aims to determine the host bacterial strains, plasmids, and genetic contexts of mcr-1 in hospital sewage.
Feifei Zhao, Feifei Zhao, Yu Feng, Yu Feng, Xiaoju Lü, Xiaoju Lü, Alan McNally, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +9 more
doaj   +3 more sources

Pogostone Enhances the Antibacterial Activity of Colistin against MCR-1-Positive Bacteria by Inhibiting the Biological Function of MCR-1

Molecules, 2022
The emergence of the plasmid-mediated colistin resistance gene mcr-1 has resulted in the loss of available treatments for certain severe infections.
Shengnan Xie, Li Li, Baihe Zhan, Xue Shen, Xuming Deng, Wenxi Tan, Tianqi Fang   +6 more
doaj   +3 more sources

Dissemination of the mcr-1 colistin resistance gene [PDF]

The Lancet Infectious Diseases, 2016
Plasmid-mediated transferable colistin resistance encoded by the mcr-1 gene was described in Escherichia coli and Klebsiella pneumoniae isolates from pigs and chicken at a prevalence of around 20%, and in clinical isolates from human beings at a prevalence of around 1% in China.1 The prevalence of the mcr-1 gene in Enterobacteriaceae in other countries
Hattie E, Webb, Sophie A, Granier, Muriel, Marault, Yves, Millemann, Henk C, den Bakker, Kendra K, Nightingale, Marie, Bugarel, Sarah A, Ison, H Morgan, Scott, Guy H, Loneragan   +9 more
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Development of a Novel mcr-6 to mcr-9 Multiplex PCR and Assessment of mcr-1 to mcr-9 Occurrence in Colistin-Resistant Salmonella enterica Isolates From Environment, Feed, Animals and Food (2011–2018) in Germany

Frontiers in Microbiology, 2020
The polymyxin antibiotic colistin has been used in decades for treatment and prevention of infectious diseases in livestock. Nowadays, it is even considered as last-line treatment option for severe human infections caused by multidrug- and carbapenem ...
Carlus Deneke, Jens A Hammerl, Burkhard Malorny   +2 more
exaly   +3 more sources

Structural biology of MCR-1-mediated resistance to polymyxin antibiotics. [PDF]

Curr Opin Struct Biol, 2023
Polymyxins, a last resort antibiotic, target the outer membrane of pathogens and are used to address the increasing prevalence of multidrug-resistant Gram-negative bacteria. The plasmid-encoded enzyme MCR-1 confers polymyxin resistance to bacteria by modifying the outer membrane.
Materon IC, Palzkill T.
europepmc   +3 more sources

Dissemination and Mechanism for the MCR-1 Colistin Resistance.

PLoS Pathogens, 2016
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance ...
Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng   +13 more
doaj   +4 more sources

Emerging Mobile Colistin Resistance Gene Mcr-1 and Mcr-10 in Enterobacteriaceae Isolates From Urban Sewage in China [PDF]

Infection and Drug Resistance
Yujing Zhang,1– 3 Jiajie Chen,1– 3 Xinyu Yang,1– 3 Yangshiyu Wu,1– 3 Zhenyu Wang,1– 3 Yawen Xu,4 Le Zhou,4 Jing Wang,1– 3 Xinan Jiao,1– 3 Lin Sun1– 3 1Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, People’s Republic of China; 2Jiangsu
Zhang Y, Chen J, Yang X, Wu Y, Wang Z, Xu Y, Zhou L, Wang J, Jiao X, Sun L   +9 more
doaj   +1 more source

Characterization of two novel colistin resistance gene mcr-1 variants originated from Moraxella spp.

Frontiers in Microbiology, 2023
This study aimed to characterize two novel mcr-1 variants, mcr-1.35 and mcr-1.36, which originated from Moraxella spp. that were isolated from diseased pigs in China. The Moraxella spp.
Yongliang Che, Yongliang Che, Renjie Wu, Renjie Wu, Hongjie Li, Longbai Wang, Longbai Wang, Xuemin Wu, Xuemin Wu, Qiuyong Chen, Qiuyong Chen, Rujing Chen, Rujing Chen, Lunjiang Zhou, Lunjiang Zhou   +14 more
doaj   +1 more source

MCR Expression Conferring Varied Fitness Costs on Host Bacteria and Affecting Bacteria Virulence

Antibiotics, 2021
Since the first report of the plasmid-mediated, colistin-resistant gene, mcr-1, nine mcr genes and their subvariants have been identified. The spreading scope of mcr-1~10 varies greatly, suggesting that mcr-1~10 may have different evolutionary advantages.
Wan Li, Zhihai Liu, Wenjuan Yin, Lu Yang, Lu Qiao, Shikai Song, Zhuoren Ling, Ruicheng Zheng, Congming Wu, Yang Wang, Jianzhong Shen   +10 more
doaj   +1 more source

Effect of Different Tolerable Levels of Constitutive mcr-1 Expression on Escherichia coli

Microbiology Spectrum, 2022
To study the effect of different tolerable levels of constitutive mcr-1 expression on Escherichia coli, and to provide direct evidence for moderate resistance mediated by mcr-1, construction of E.
Han Qiao, Jie Yu, Xiukun Wang, Tongying Nie, Xinxin Hu, Xinyi Yang, Congran Li, Xuefu You   +7 more
doaj   +1 more source