MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria
Emerging Microbes and Infections, 2022 The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human health. Recent studies by our group and others have shown that the withdrawal of colistin as a feed additive dramatically reduced the prevalence of mcr-1. Although
Siyuan Feng +15 more
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Identification of Functional Interactome of Colistin Resistance Protein MCR-1 in Escherichia coli
Frontiers in Microbiology, 2021 The emergence and worldwide dissemination of plasmid-mediated colistin resistance gene mcr-1 has attracted global attention. The MCR-1 enzyme mediated colistin resistance by catalyzing phosphoethanolamine (PEA) transfer onto bacterial lipid A.
Hui Li +7 more
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Frontiers in Microbiology, 2022 IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Christa Ewers +5 more
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Prevalence of mcr-1 in E. coli from Livestock and Food in Germany, 2010–2015 [PDF]
, 2016 Since the first description of a plasmid-mediated colistin resistance gene (mcr-1) in November 2015 multiple reports of mcr-1 positive isolates indicate a worldwide spread of this newly discovered resistance gene in Enterobacteriaceae.
Grobbel, Mirjam +7 more
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Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs
BMC Research Notes, 2018 Objective Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3,
Jilei Zhang +8 more
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Journal of Global Antimicrobial Resistance, 2022 : Objectives: This study investigated the prevalence and characteristics of mcr-1-harbouring Escherichia coli isolated from chickens in central China from 2014 to 2019. Methods: A total of 1132 E.
Wenting Zhang +10 more
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In-vitro study of ISApl1-mediated mobilization of the colistin resistance gene mcr-1 [PDF]
, 2017 The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase conferring resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family).
Kieffer, Nicolas +2 more
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Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa [PDF]
, 2016 A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones.
Brink, Adrian +5 more
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In Vitro/Vivo Activity of Potential MCR-1 Inhibitor in Combination With Colistin Againsts mcr-1-Positive Klebsiella pneumonia [PDF]
Frontiers in Microbiology, 2018 Carbapenem resistance among strains of the nosocomial pathogen Klebsiella pneumoniae is increasing worldwide, causing serious clinical infections and higher mortality rates. Polymyxins are some of the few "last resort" options for treatment of carbapenem-resistant Enterobacteriaceae, including K.
Yonglin Zhou +12 more
openaire +3 more sources
Molecular insights into functional differences between mcr-3- and mcr-1-mediated colistin resistance [PDF]
, 2018 The global emergence of plasmid-mediated colistin resistance genes mcr-1 and mcr-3 has threatened the role of the “last resort” drug colistin in the defense against infections caused by multidrug-resistant Gram-negative bacteria.
Li, Hui +8 more
core +2 more sources