Results 21 to 30 of about 30,237 (249)

Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli

Frontiers in Microbiology, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Christa Ewers, Lisa Göpel, Ellen Prenger-Berninghoff, Torsten Semmler, Katharina Kerner, Rolf Bauerfeind   +5 more
doaj   +1 more source

Prevalence of colistin resistance gene mcr-1 in Escherichia coli isolated from chickens in central China, 2014 to 2019

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This study investigated the prevalence and characteristics of mcr-1-harbouring Escherichia coli isolated from chickens in central China from 2014 to 2019. Methods: A total of 1132 E.
Wenting Zhang, Tengfei Zhang, Chen Wang, Guixing Liang, Qin Lu, Guoyuan Wen, Yunqing Guo, Yiluo Cheng, Zui Wang, Huabin Shao, Qingping Luo   +10 more
doaj   +1 more source

Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs

BMC Research Notes, 2018
Objective Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3,
Jilei Zhang, Li Chen, Jiawei Wang, Patrick Butaye, Ke Huang, Haixiang Qiu, Xiaomei Zhang, Weijuan Gong, Chengming Wang   +8 more
doaj   +1 more source

Identification of Functional Interactome of Colistin Resistance Protein MCR-1 in Escherichia coli

Frontiers in Microbiology, 2021
The emergence and worldwide dissemination of plasmid-mediated colistin resistance gene mcr-1 has attracted global attention. The MCR-1 enzyme mediated colistin resistance by catalyzing phosphoethanolamine (PEA) transfer onto bacterial lipid A.
Hui Li, Yingyu Wang, Qiyan Chen, Xi Xia, Jianzhong Shen, Yang Wang, Bing Shao, Bing Shao   +7 more
doaj   +1 more source

Ecology of blaNDM and mcr-1

Journal of Laboratory and Precision Medicine, 2017
Antibiotic resistance is one of the most worrying threats to global public health today. Numerous common infections are becoming harder, and even impossible, to treat due to the loss of effectiveness of these molecules against resistant bacteria.
Jose Francisco Delgado-Blas, Bosco R. Matamoros, Bruno Gonzalez-Zorn   +2 more
openaire   +1 more source

In Vitro/Vivo Activity of Potential MCR-1 Inhibitor in Combination With Colistin Againsts mcr-1-Positive Klebsiella pneumonia [PDF]

Frontiers in Microbiology, 2018
Carbapenem resistance among strains of the nosocomial pathogen Klebsiella pneumoniae is increasing worldwide, causing serious clinical infections and higher mortality rates. Polymyxins are some of the few "last resort" options for treatment of carbapenem-resistant Enterobacteriaceae, including K.
Yonglin Zhou, Yonglin Zhou, Tingting Wang, Tingting Wang, Yan Guo, Shui Liu, Jianfeng Wang, Jianfeng Wang, Yingbo Shen, Shusheng Tang, Yang Wang, Xuming Deng, Xuming Deng   +12 more
openaire   +3 more sources

Prevalence of mcr-1 in Colonized Inpatients, China, 2011–2019 [PDF]

Emerging Infectious Diseases, 2021
In response to the spread of colistin resistance gene mcr-1, China banned the use of colistin in livestock fodders. We used a time-series analysis of inpatient colonization data from 2011-2019 to accurately reveal the associated fluctuations of mcr-1 that occurred in inpatients in response to the ban.
Cong Shen, Lan-Lan Zhong, Zhijuan Zhong, Yohei Doi, Jianzhong Shen, Yang Wang, Furong Ma, Mohamed Abd El-Gawad El-Sayed Ahmed, Guili Zhang, Yong Xia, Cha Chen, Guo-Bao Tian   +11 more
openaire   +3 more sources

Genetic basis of chromosomally-encoded mcr-1 gene [PDF]

International Journal of Antimicrobial Agents, 2018
Compared with plasmid-borne mcr-1, the occurrence of chromosomally-encoded mcr-1 is rare although it has been reported in several cases. This study aimed to investigate the genetic features of chromosomally-encoded mcr-1 among Escherichia coli strains as well as the potential genetic basis governing mobilisation of mcr-1 in bacterial chromosomes.
Ruichao, Li, Hua, Yu, Miaomiao, Xie, Kaichao, Chen, Ning, Dong, Dachuan, Lin, Edward Wai-Chi, Chan, Sheng, Chen   +7 more
openaire   +5 more sources

Elimination of the risks of colistin resistance gene (mcr-1) in livestock manure during composting

Environment International, 2019
Since its discovery in Escherichia coli, the emergence and rapid spread of the plasmid-mediated colistin resistance gene mcr-1 have become a public health concern.
Yanzheng Gao, Chao Lu, Di Shen, Juan Liu, Zhao Ma, Bing Yang, Wanting Ling, Michael Gatheru Waigi   +7 more
doaj   +1 more source

First detection of mcr-1-producing Escherichia coli in Greece

Journal of Global Antimicrobial Resistance, 2022
In this communication, we describe the emergence of the mcr-1 colistin resistance gene in a blaCTX-M-32 extended-spectrum-β-lactamase-producing Escherichia coli isolate recovered from a pediatric patient in Greece.Bacterial identification and antimicrobial susceptibility testing were performed with the VITEK2 automated system and broth microdilution ...
Efthymia Protonotariou, Georgios Meletis, Andigoni Malousi, Charalampos Kotzamanidis, Areti Tychala, Paraskevi Mantzana, Kalliopi Theodoridou, Maria Ioannidou, Emmanuel Hatzipantelis, Athanasios Tsakris, Lemonia Skoura   +10 more
openaire   +4 more sources