Deciphering MCR-2 Colistin Resistance [PDF]
MBio, 2017 Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria.
Xing-Ping Li +2 more
exaly +7 more sources
Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli [PDF]
Frontiers in Microbiology, 2022 IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Christa Ewers +5 more
doaj +8 more sources
ISEc69-Mediated Mobilization of the Colistin Resistance Gene mcr-2 in Escherichia coli [PDF]
Frontiers in Microbiology, 2021 ObjectivesThe emergence of mobile colistin resistance genes has compromised the efficacy of the last resort antibiotic, colistin, in clinical treatment.
Yu-Zhang He +16 more
doaj +5 more sources
Screening for fecal presence of colistin-resistant Escherichia coli and mcr-1 and mcr-2 genes in camel-calves in southern Tunisia [PDF]
Acta Veterinaria Scandinavica, 2018 Camels (Camelus dromedarius) are known to harbor multidrug resistant Gram-negative bacteria and to be involved in the transmission of various microorganisms to humans.
Mohamed Rhouma +5 more
doaj +5 more sources
Evidence of colistin resistance genes (mcr-1 and mcr-2) in wild birds and its public health implication in Egypt. [PDF]
Antimicrob Resist Infect Control, 2019 Abstract Background Antimicrobial resistance has become one of the most severe global threats to human and veterinary Medicine. colistin is an effective therapeutic agent against multi-drug-resistant pathogens. However, the discovery of transferable plasmids that confer resistance to colistin (mcr-1) has led to challenges in medical science. This study
Ahmed ZS +4 more
europepmc +5 more sources
1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2. [PDF]
Acta Crystallogr F Struct Biol Commun, 2017 MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 Å resolution crystal structure of the catalytic domain of MCR-2 was determined.
Coates K +3 more
europepmc +5 more sources
Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland [PDF]
International Journal of Infectious Diseases, 2016 • This is the first prospective analysis of the prevalence of MCR-1 and MCR-2 in clinical samples.
Laurent Poirel +2 more
exaly +7 more sources
Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong [PDF]
BMC Infectious Diseases, 2018 Background Human fecal carriage of Enterobacteriaceae possessing mobilized colistin resistance genes (mcr-1 and mcr-2) remains obscure in Hong Kong. As part of routine surveillance on emerging antibiotic resistance, we conducted a prospective study on ...
Wai-Sing Chan +5 more
doaj +3 more sources
Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry [PDF]
Scientific Reports, 2018 Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339
Jilei Zhang +20 more
doaj +4 more sources
Advanced Science, 2019 A growing number of mobile colistin resistance (MCR) proteins is threatening the renewed interest of colistin as a “last‐resort” defense against carbapenem‐resistant pathogens.
Yu Feng, Youjun Feng
exaly +2 more sources