Identification of mcr-2 and mcr-3 Genes in Colistin‐Resistant E. coli O157:H7 Isolated From Raw Meat Samples in Beirut, Lebanon [PDF]
International Journal of MicrobiologyColistin is a last‐resort antibiotic used to treat multidrug‐resistant Gram‐negative bacterial infections. The global emergence of colistin resistance has been attributed to plasmid‐mediated mobile colistin resistance ( mcr ) genes. In Lebanon, bacteria carrying the mcr-1
Fatima H. Fneish +2 more
openaire +4 more sources
PLoS ONE, 2017 The rapid spreading of polymyxin E (colistin) resistance among bacterial strains through the horizontally transmissible mcr-1 and mcr-2 plasmids has become a serious concern.
Daniela Mavrici +4 more
doaj +4 more sources
Screening for fecal presence of colistin-resistant Escherichia coli and mcr-1 and mcr-2 genes in camel-calves in southern Tunisia [PDF]
Acta Veterinaria Scandinavica, 2018 Camels (Camelus dromedarius) are known to harbor multidrug resistant Gram-negative bacteria and to be involved in the transmission of various microorganisms to humans.
Mohamed Rhouma +5 more
doaj +3 more sources
Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria [PDF]
Advanced Science, EarlyView.Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song +9 more
wiley +2 more sources
Transforming Lives: The First 18 Months of the MCR Pathways Mentoring Programme
, 2014 The programme is school-based and aimed at young people who are ‘looked after’ by the local authority or have previously been looked after. The MCR Pathways Mentoring Programme involves four partners: the MCR Charitable Foundation; Glasgow City Council ...
Siebelt, L., Mitchell, I., Fassetta, G.
core +7 more sources
Rapid Polymyxin NP test for the detection of polymyxin resistance mediated by the mcr-1/mcr-2 genes [PDF]
Diagnostic Microbiology and Infectious Disease, 2018 The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR-1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans.
Poirel, Laurent +6 more
openaire +5 more sources
Plasmid maps of pACYC-Para-MCR-1 and pACYC-NP-MCR-1.
, 2023 The plasmid for expressing MCR-1 or M6 under the regulation of arabinose promoter was shown as (A), and the one for expressing target proteins under the regulation of MCR-1 native promoter was shown as (B).
Chenchen Zhang (324804) +16 more
core +1 more source
Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016 [PDF]
Eurosurveillance, 2016 We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53)
Xavier, Basil Britto +6 more
openaire +3 more sources
, 2023 Associated paper: Regulatory fine-tuning and horizontal gene transfer stabilize mobile colistin resistance Lois Ogunlana, Liam P. Shaw, Divjot Kaur, Pramod Jangir, Timothy Walsh, Stephan Uphoff, and R.C. MacLean. Preprint version: https://doi.org/10.
Liam Shaw (5487083)
core +1 more source
, 2022 IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650) +5 more
core +1 more source