Mobile Colistin Resistance Enzyme MCR‐3 Facilitates Bacterial Evasion of Host Phagocytosis [PDF]
Advanced Science, 2021 Mobile colistin resistance enzyme MCR‐3 is a phosphoethanolamine transferase modifying lipid A in Gram‐negative bacteria. MCR‐3 generally mediates low‐level (≤8 mg L−1) colistin resistance among Enterobacteriaceae, but occasionally confers high‐level ...
Wenjuan Yin +16 more
doaj +3 more sources
Fitness costs of mobilised colistin resistance gene 3 (mcr-3): systematic review, epidemiological study, and functional analysisResearch in context [PDF]
EBioMedicineSummary: Background: The rapid evolution and dissemination of mobilised colistin resistance gene (mcr) family has revealed as a severe threat to the global public health.
Lujie Liang +22 more
doaj +3 more sources
Prevalence and Genetic Analysis of Chromosomal mcr-3/7 in Aeromonas From U.S. Animal-Derived Samples [PDF]
Frontiers in Microbiology, 2021 The prevalence of mcr-positive bacteria in 5,169 domestic animal-derived samples collected by USDA Food Safety and Inspection Service between October 2018 and May 2019 was investigated.
Yan Wang +5 more
doaj +3 more sources
Characterisation of mobile colistin resistance genes (mcr-3 and mcr-5) in river and storm water in regions of the Western Cape of South Africa [PDF]
Antimicrobial Resistance and Infection Control, 2021 Background Colistin is regarded as a last-resort antimicrobial against multi-drug resistant Gram-negative bacteria (GNB), therefore the dissemination of colistin resistance in the environment is of great concern.
Yolandi Snyman +4 more
doaj +3 more sources
Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic StudyResearch in Context [PDF]
EBioMedicine, 2018 Background: Mobilized resistance to colistin is evolving rapidly and its global dissemination poses a severe threat to human health and safety. Transferable colistin resistance gene, mcr-3, first identified in Shandong, China, has already been found in ...
Yongchang Xu +13 more
doaj +3 more sources
Co-occurrence of Variants of mcr-3 and mcr-8 Genes in a Klebsiella pneumoniae Isolate From Laos [PDF]
Frontiers in Microbiology, 2019 Colistin is considered as a last resort antibiotic. The re-use of this antibiotic highlighted the emergence of colistin resistance mediated by chromosomal and plasmidic resistance mechanisms.
Linda Hadjadj +10 more
doaj +3 more sources
Aeromonas and mcr–3: A Critical Juncture for Transferable Polymyxin Resistance in Gram-Negative Bacteria [PDF]
PathogensPolymyxin antibiotics B and colistin are considered drugs of last resort for the treatment of multi-drug and carbapenem-resistant Gram-negative bacteria.
Nathan L. McDonald +2 more
doaj +3 more sources
Emergence of mcr-3 carrying Escherichia coli in Diseased Pigs in South Korea [PDF]
Microorganisms, 2020 We examined the prevalence and molecular characteristics of mcr-3 carrying colistin-resistant Escherichia coli among cattle, pig, and chicken isolates in South Korea. Among a total of 185 colistin-resistant E.
Abraham Fikru Mechesso +11 more
doaj +3 more sources
Mobile Colistin-Resistant Genes mcr-1, mcr-2, and mcr-3 Identified in Diarrheal Pathogens among Infants, Children, and Adults in Bangladesh: Implications for the Future [PDF]
AntibioticsColistin is a last-resort antimicrobial for treating multidrug-resistant Gram-negative bacteria. Phenotypic colistin resistance is highly associated with plasmid-mediated mobile colistin resistance (mcr) genes.
Shafiuzzaman Sarker +9 more
doaj +3 more sources
Distribution and Transmission of Colistin Resistance Genes mcr-1 and mcr-3 among Nontyphoidal Salmonella Isolates in China from 2011 to 2020. [PDF]
Microbiol Spectr, 2023 Nontyphoidal Salmonella is one of four major causative agents of diarrheal diseases globally, with most cases of salmonellosis being mild. Antimicrobial treatments are required for cases of life-threatening infections, and colistin is one of the last ...
Yang T +13 more
europepmc +2 more sources