Novel Plasmid-Mediated Colistin Resistance Gene
mBio, 2017 The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria.
Wenjuan Yin +9 more
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Alkaline Peptone Water-Based Enrichment Method for mcr-3 From Acute Diarrheic Outpatient Gut Samples [PDF]
Frontiers in Medicine, 2018 A third plasmid-mediated colistin resistance gene, mcr-3, is increasingly being reported in Enterobacteriaceae and Aeromonas spp. from animals and humans. To investigate the molecular epidemiology of mcr in the gut flora of Chinese outpatients, 152 stool
Qiaoling Sun +6 more
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The MCR-3 inside linker appears as a facilitator of colistin resistance [PDF]
Cell Reports, 2021 Summary: An evolving family of mobile colistin resistance (MCR) enzymes is threatening public health. However, the molecular mechanism by which the MCR enzyme as a rare member of lipid A-phosphoethanolamine (PEA) transferases gains the ability to confer ...
Yongchang Xu +5 more
doaj +4 more sources
Complete Genome Sequence of Aeromonas caviae Strain MS6064, a mcr-3-Carrying Clinical Isolate from Japan. [PDF]
Microbiol Resour Announc, 2021 We report the complete genome sequence of mcr-3-carrying Aeromonas caviae strain MS6064, isolated from a blood sample from a Japanese patient. The strain carried mcr-3 variant 3.38 and was borderline resistant to colistin (2 μg/ml).
Yu L +5 more
europepmc +4 more sources
Emergence of Escherichia coli harbouring mcr-1 and mcr-3 genes in North West Algerian farmlands
Journal of Global Antimicrobial Resistance, 2020 Objectives: Colistin resistance has emerged worldwide, threatening the efficacy of colistin treatment of Gram-negative bacterial infections. Farms have been recognised as an important reservoir of genes conferring resistance to colistin. This study aimed
Meriem Touati +4 more
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Macrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli. [PDF]
PLoS PathogensMobile colistin resistance (mcr) genes compromise the efficacy of last-resort polymyxin antibiotics. Notably, the global prevalence of mcr-3 has continued to increase despite reductions in colistin use, suggesting that selective forces beyond direct ...
Shuyu Tan +15 more
doaj +3 more sources
SciInappropriate antimicrobial use in food animal farming propels antimicrobial resistance (AMR) that affects all health domains. Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being ...
Mamun Al Asad +9 more
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A Novel Transposon, Tn6518, Mediated Transfer of mcr-3 Variant in ESBL-Producing Aeromonas veronii
Infection and Drug Resistance, 2020 Xiaoming Wang,1,2 Weishuai Zhai,3 Shaolin Wang,2 Zhangqi Shen,2 Yang Wang,2 Qidi Zhang3 1MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People&rsquo ...
Wang X +5 more
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Potential transferability of mcr-3 via IS26-mediated homologous recombination in Escherichia coli. [PDF]
Emerg Microbes Infect, 2018 Worldwide dissemination of the mobile colistinresistance gene mcr-1 is of great concern to public health. Recently, a novel colistin-resistance gene, mcr-3, was reported to share 45.0% nucleotide sequence identity with mcr-1.
Wang Z, Fu Y, Du XD, Jiang H, Wang Y.
europepmc +5 more sources
MCR-3 and MCR-9 confer species-specific increases in colistin MICs. [PDF]
Microbiology (Reading)For the clinical treatment of infections with Enterobacteriaceae, the development of resistance to last-resort antimicrobials like colistin is of concern, as it limits treatment options.
Schumann A, Wiedmann M.
europepmc +3 more sources