Results 11 to 20 of about 24,617,760 (271)

Mobile Colistin-Resistant Genes mcr-1, mcr-2, and mcr-3 Identified in Diarrheal Pathogens among Infants, Children, and Adults in Bangladesh: Implications for the Future [PDF]

Antibiotics
Colistin is a last-resort antimicrobial for treating multidrug-resistant Gram-negative bacteria. Phenotypic colistin resistance is highly associated with plasmid-mediated mobile colistin resistance (mcr) genes.
Shafiuzzaman Sarker, Reeashat Muhit Neeloy, Marnusa Binte Habib, Umme Laila Urmi, Mamun Al Asad, Abu Syed Md. Mosaddek, Mohammad Rabiul Karim Khan, Shamsun Nahar, Brian Godman, Salequl Islam   +9 more
doaj   +7 more sources

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry [PDF]

Scientific Reports, 2018
Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339
Jilei Zhang, Li Chen, Jiawei Wang, Afrah Kamal Yassin, Patrick Butaye, Patrick Kelly, Jiansen Gong, Weina Guo, Jing Li, Min Li, Feng Yang, Zhixing Feng, Ping Jiang, Chunlian Song, Yaoyao Wang, Jinfeng You, Yi Yang, Stuart Price, Kezong Qi, Yuan Kang, Chengming Wang   +20 more
doaj   +6 more sources

Induction of proteome changes involved in the cloning of mcr-1 and mcr-2 genes in Escherichia coli DH5-α strain to evaluate colistin resistance

Journal of Global Antimicrobial Resistance
: Objectives: Plasmid genes, termed mobile colistin resistance-1 (mcr-1) and mobile colistin resistance-2 (mcr-2), are associated with resistance to colistin in Escherichia coli (E. coli).
Hadi Feizi, Maryam Alizadeh, Hadi Azimi, Ehsaneh Khodadadi, Fadhil S. Kamounah, Khudaverdi Ganbarov, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Hossein Samadi Kafil   +8 more
doaj   +4 more sources

Culture-Independent Quantitative PCR Detected Mobilized Colistin Resistance Genes (mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5) in Chicken Gut Contents in Bangladesh

Sci
Inappropriate antimicrobial use in food animal farming propels antimicrobial resistance (AMR) that affects all health domains. Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being ...
Mamun Al Asad, Md Sarower Hossen Shuvo, Shomaia Yasmin Mitu, Sumia, Md Asief Hossain Zihadi, Ayasha Siddique Shanta, Nahidul Islam, Shamsun Nahar, Brian Godman, Salequl Islam   +9 more
doaj   +5 more sources

Evidence of colistin resistance genes (mcr-1 and mcr-2) in wild birds and its public health implication in Egypt [PDF]

Antimicrobial Resistance & Infection Control, 2019
Abstract Background Antimicrobial resistance has become one of the most severe global threats to human and veterinary Medicine. colistin is an effective therapeutic agent against multi-drug-resistant pathogens. However, the discovery of transferable plasmids that confer resistance to colistin (mcr-1) has led to challenges in medical science. This study
Zeinab Ahmed, Esraa A. Elshafiee, Hanan S. Khalefa, Mona Kadry, Dalia Hamza   +4 more
openaire   +4 more sources

1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2 [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2017
MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 Å resolution crystal structure of the catalytic domain of MCR-2 was determined.
Coates, Katie, Walsh, Timothy R., Spencer, James, Hinchliffe, Philip   +3 more
openaire   +4 more sources

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases [PDF]

Advanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang, Yichong Sun, Xiaoting Zhang, Chi‐Kwan Lee, Zheng Li, Yehui Li, Huarong Chen, Paul D. Mitcheson   +7 more
wiley   +2 more sources

Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes [PDF]

Eurosurveillance, 2018
Background and aim: Plasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 ...
Hammerl, Jens Andre, Sophie A Granier, Cristina De Frutos Escobar, Kjeldgaard, Jette,, Ana Rita Rebelo, Carattoli, Alessandra, Borowiak, Maria, Valeria Bortolaia, Maria Borowiak, Hendriksen, Rene S., Patricia Alba, Hendriksen, Rene,, Hansen, Inge,, Malorny, Burkhard, Granier, Sophie, Surbhi Malhotra-Kumar, Antonio Battisti, De Frutos Escobar, Cristina, Franco, Alessia, Inge M Hansen, Rene S Hendriksen, Hammerl, Jens,, Pedersen, Susanne,, Leekitcharoenphon, Pimlapas, Hansen, Inge M., Rebelo, Ana Rita, de Frutos, Cristina, Jette S Kjeldgaard, Alessia Franco, Pedersen, Susanne K., Karlsmose Pedersen, Susanne, Malhotra-Kumar, Surbhi, Kjeldgaard, Jette S., Pimlapas Leekitcharoenphon, Alba, Patricia, Burkhard Malorny, Rebelo, Ana-Rita, Alessandra Carattoli, Granier, Sophie A., Beatriz Guerra, Perrin-Guyomard, Agnes, Battisti, Antonio, Bortolaia, Valeria, Escobar, Susanne K Pedersen, Agnes Perrin-Guyomard, Guerra, Beatriz, Laura Villa, Malhotra, Surbhi, Jens Andre Hammerl, Villa, Laura   +50 more
core   +9 more sources

Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong [PDF]

BMC Infectious Diseases, 2018
Background Human fecal carriage of Enterobacteriaceae possessing mobilized colistin resistance genes (mcr-1 and mcr-2) remains obscure in Hong Kong. As part of routine surveillance on emerging antibiotic resistance, we conducted a prospective study on ...
Wai-Sing Chan, Chun-Hang Au, Dona N. Ho, Tsun-Leung Chan, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang   +5 more
doaj   +3 more sources

mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015 [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Objectives To determine the occurrence of mcr-1 and mcr-2 genes in Gram-negative bacteria isolated from healthy pigs in Great Britain. Methods Gram-negative bacteria (n"657) isolated from pigs between 2014 and 2015 were examined by WGS.
Nick A Duggett, Miranda Kirchner, Crook, DW, Javier Nunez-Garcia, Luisa Dormer, Lemma, F, Anjum, MF, Teale, C, Kirchner, M, Emma J Stubberfield, Luke P Randall, Fabrizio Lemma, Duggett, NA, Smith, RP, Crook, Derrick W., Richard P Smith, Manal AbuOun, Stubberfield, EJ, Derrick W Crook, Randall, LP, Nunez-Garcia, J, Muna F Anjum, AbuOun, M, Christopher Teale, Dormer, L   +24 more
core   +6 more sources