An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity.
Piyatip Khuntayaporn +5 more
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One Health study of mobile colistin resistance (mcr) in Salmonella enterica in Canada, 2017–2022 [PDF]
Microbiology SpectrumColistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184 Salmonella isolates collected from 2017 to 2022 in Canada from human and animal/food sources, mobile colistin resistance (mcr) variants conferring colistin ...
Ketna Mistry +26 more
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Screening for mobile colistin resistance gene-9 (mcr-9) in multidrug resistant uropathogenic Escherichia coli isolated from patients with urinary tract infections [PDF]
BMC Research NotesObjective Colistin and Polymyxin B form the reserve group of antibiotics. Resistance to colistin has been increasing across the world including India, posing treatment challenges to clinicians.
Divya Lakshmanan +5 more
doaj +3 more sources
Is Africa ready for mobile colistin resistance threat? [PDF]
Infection Ecology and Epidemiology, 2021 Antimicrobial resistance is a growing public health problem and a threat to effective treatment and prevention of an array of infections caused by bacteria. Africa is already faced with many socio-economic and health crises. Many countries in Africa can seldom boast of a standardized health care facility comparable to those in developed countries. Yet,
James Wabwire Oguttu +2 more
exaly +6 more sources
The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges
Microorganisms, 2021 Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ...
Mouna Hamel +2 more
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The first report of the mobile colistin resistance gene, mcr-10.1, in Kenya and a novel mutation in the phoQ gene (S244T) in a colistin-resistant Enterobacter cloacae clinical isolate [PDF]
Microbiology SpectrumThis study describes the identification of the mcr-10.1 gene in a clinical isolate of an ST1 Enterobacter cloacae isolate cultured in 2015 in Kenya. The isolate was multidrug resistant, phenotypically non-susceptible to various antibiotics, including ...
Collins Kigen +3 more
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Audacious Hitchhikers: The Role of Travel and the International Food Trade in the Global Dissemination of Mobile Colistin-Resistance (mcr) Genes [PDF]
Antibiotics, 2020 Colistin, a last-resort antibiotic, has been used in controlling infections caused by multidrug-resistant Gram-negative bacterial pathogens. However, recent reports showed a global dissemination of mobile colistin-resistance (mcr) genes, genetic elements
Jouman Hassan, Issmat I. Kassem
doaj +2 more sources
Poultry Science, 2020 Colibacillosis, caused by Escherichia coli, is one of the most common bacterial diseases of chickens. The high incidence and considerable economic losses associated with colibacillosis make it a significant concern worldwide.
Yanying Song +9 more
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mcr-1-Mediated In Vitro Inhibition of Plasmid Transfer Is Reversed by the Intestinal Environment
Antibiotics, 2022 Colistin is regarded as an antibiotic of last resort against multidrug-resistant Gram-negative bacteria, including Klebsiella pneumoniae and Escherichia coli.
Xiaoman Yang +7 more
doaj +1 more source
Advanced Science, 2023 The emergence and prevalence of mobile colistin resistance gene mcr have dramatically compromised the clinical efficacy of colistin, a cyclopeptide antibiotic considered to be the last option for treating different‐to‐treat infections.
Jinju Cai +5 more
doaj +1 more source