Results 1 to 10 of about 3,785,189 (191)

An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity.
Piyatip Khuntayaporn, Piyatip Khuntayaporn, Krit Thirapanmethee, Krit Thirapanmethee, Mullika Traidej Chomnawang, Mullika Traidej Chomnawang   +5 more
doaj   +6 more sources

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

Engineering, 2023
The emergence and spread of the mobile colistin-resistance gene, mcr-1, and its variants pose a challenge to the use of colistin, a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant (XDR) Gram-negative pathogens.
Huangwei Song, Xueyang Wang, Muchen Zhang, Zhiyu Zou, Siyuan Yang, Tian Yi, Jianfeng Wang, Dejun Liu, Yingbo Shen, Chongshan Dai, Zhihai Liu, Timothy R. Walsh, Jianzhong Shen, Congming Wu, Yang Wang   +14 more
doaj   +5 more sources

One Health study of mobile colistin resistance (mcr) in Salmonella enterica in Canada, 2017–2022 [PDF]

Microbiology Spectrum
Colistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184 Salmonella isolates collected from 2017 to 2022 in Canada from human and animal/food sources, mobile colistin resistance (mcr) variants conferring colistin ...
Ketna Mistry, David Thumbi, Xiao Rui Li, Audrey Charlebois, Brent P. Avery, Anne E. Deckert, Ashley C. Cormier, Colleen Murphy, Ashley Kearney, Jennifer Campbell, Sara Christianson, David C. Alexander, Sameh El Bailey, Sadjia Bekal, Linda Chui, Xiaofeng Ding, Tanis Dingle, David Haldane, Linda Hoang, Jessica Minion, Samir Patel, George Zahariadis, Celine Nadon, Michael R. Mulvey, Carolee A. Carson, Richard J. Reid-Smith, Amrita Bharat   +26 more
doaj   +4 more sources

Screening for mobile colistin resistance gene-9 (mcr-9) in multidrug resistant uropathogenic Escherichia coli isolated from patients with urinary tract infections [PDF]

BMC Research Notes
Objective Colistin and Polymyxin B form the reserve group of antibiotics. Resistance to colistin has been increasing across the world including India, posing treatment challenges to clinicians.
Divya Lakshmanan, K. Vanathy, Catherine Thamayandhi, Sreejith Sreekumaran, E. K. Radhakrishnan, S. Srirangaraj   +5 more
doaj   +3 more sources

Audacious Hitchhikers: The Role of Travel and the International Food Trade in the Global Dissemination of Mobile Colistin-Resistance (mcr) Genes [PDF]

Antibiotics, 2020
Colistin, a last-resort antibiotic, has been used in controlling infections caused by multidrug-resistant Gram-negative bacterial pathogens. However, recent reports showed a global dissemination of mobile colistin-resistance (mcr) genes, genetic elements
Jouman Hassan, Issmat I. Kassem
doaj   +4 more sources

Mobile Colistin Resistance Enzyme MCR-3 Facilitates Bacterial Evasion of Host Phagocytosis. [PDF]

Adv Sci (Weinh), 2021
AbstractMobile colistin resistance enzyme MCR‐3 is a phosphoethanolamine transferase modifying lipid A in Gram‐negative bacteria. MCR‐3 generally mediates low‐level (≤8 mg L−1) colistin resistance among Enterobacteriaceae, but occasionally confers high‐level (>128 mg L−1) resistance in aeromonads.
Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR, Dai C, Li J, Yang H, Liu D, Wang Y, Gao GF, Shen J.   +16 more
europepmc   +6 more sources

The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges

Microorganisms, 2021
Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ...
Mouna Hamel, Jean-Marc Rolain, Sophie Alexandra Baron   +2 more
doaj   +2 more sources

The first report of the mobile colistin resistance gene, mcr-10.1, in Kenya and a novel mutation in the phoQ gene (S244T) in a colistin-resistant Enterobacter cloacae clinical isolate [PDF]

Microbiology Spectrum
This study describes the identification of the mcr-10.1 gene in a clinical isolate of an ST1 Enterobacter cloacae isolate cultured in 2015 in Kenya. The isolate was multidrug resistant, phenotypically non-susceptible to various antibiotics, including ...
Collins Kigen, Angela Muraya, James Wachira, Lillian Musila   +3 more
doaj   +2 more sources

mcr-1-Mediated In Vitro Inhibition of Plasmid Transfer Is Reversed by the Intestinal Environment

Antibiotics, 2022
Colistin is regarded as an antibiotic of last resort against multidrug-resistant Gram-negative bacteria, including Klebsiella pneumoniae and Escherichia coli.
Xiaoman Yang, Rundong Shu, Leqi Hou, Panpan Ren, Xin Lu, Zhi Huang, Zengtao Zhong, Hui Wang   +7 more
doaj   +1 more source

Prevalence and characteristics of multidrug-resistant mcr-1-positive Escherichia coli isolates from broiler chickens in Tai'an, China

Poultry Science, 2020
Colibacillosis, caused by Escherichia coli, is one of the most common bacterial diseases of chickens. The high incidence and considerable economic losses associated with colibacillosis make it a significant concern worldwide.
Yanying Song, Lanping Yu, Yu Zhang, Yu Dai, Peng Wang, Chenglian Feng, Mengda Liu, Shuhong Sun, Zhijing Xie, Fangkun Wang   +9 more
doaj   +1 more source