Results 1 to 10 of about 14,893 (111)

Large-scale genomic survey and characterization of mcr genes carried by foodborne Cronobacter isolates [PDF]

mSystems, 2023
Antibiotic resistance has become a worldwide public health and biosafety problem. The clinical efficacy of colistin was jeopardized by the report of the first mobile colistin resistance (mcr) gene, and subsequently, the mcr-gene family of mcr-1 to mcr-10
Qianhui Zhu, Jinrui Hu, Na Liu, Heyuan Qi, Xiaoli Du, Zhigang Cui, Yan Sun, Yadong Liu, Songnian Hu, Linhuan Wu, Haijian Zhou, Zilong He, Juncai Ma   +12 more
doaj   +2 more sources

Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundMobile colistin resistance (mcr) genes modify Lipid A molecules of the lipopolysaccharide, changing the overall charge of the outer membrane.Results and discussionTen mcr genes have been described to date within eleven Enterobacteriaceae ...
Masego Mmatli, Nontombi Marylucy Mbelle, John Osei Sekyere, John Osei Sekyere, John Osei Sekyere   +4 more
doaj   +2 more sources

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks [PDF]

Pathogens, 2022
Background: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through mcr ...
Afaf Hamame, Bernard Davoust, Zineb Cherak, Jean-Marc Rolain, Seydina M. Diene   +4 more
doaj   +2 more sources

Analysis of mobile genetic elements carrying mcr genes in clinical Leclercia spp. isolates [PDF]

BMC Microbiology
Background Leclercia adecarboxylata is an emerging clinical pathogen within the Enterobacteriaceae family and causes infections in immunocompromised and immunocompetent patients.
Dayong Chen, Ting Xie, Minghui Liu, Dongsheng Zhou, Hongning Wang, Lijun Zeng, Zhe Yin   +6 more
doaj   +2 more sources

Co-occurrence of Variants of mcr-3 and mcr-8 Genes in a Klebsiella pneumoniae Isolate From Laos

Frontiers in Microbiology, 2019
Colistin is considered as a last resort antibiotic. The re-use of this antibiotic highlighted the emergence of colistin resistance mediated by chromosomal and plasmidic resistance mechanisms.
Jean-Marc Rolain, Sophie Baron, Abiola Olumuyiwa Olaitan   +2 more
exaly   +3 more sources

Comprehensive Genomic Investigation of Coevolution of mcr genes in Escherichia coli Strains via Nanopore Sequencing

Global Challenges, 2021
Horizontal gene transfer facilitates the spread of antibiotic resistance genes, which constitutes a global challenge. However, the evolutionary trajectory of the mobile colistin resistome in bacteria is largely unknown. To investigate the coevolution and
Li Ruichao
exaly   +2 more sources

Colistin Resistant mcr Genes Prevalence in Livestock Animals (Swine, Bovine, Poultry) from a Multinational Perspective. A Systematic Review [PDF]

Veterinary Sciences, 2021
The objective of this review is to collect and present the results of relevant studies on an international level, on the subject of colistin resistance due to mcr genes prevalence in livestock animals.
George Valiakos, Ioanna Kapna
doaj   +2 more sources

A multiplex TaqMan real-time PCR assays for the rapid detection of mobile colistin resistance (mcr-1 to mcr-10) genes

Frontiers in Microbiology
ObjectiveRecently, 10 plasmid-mediated mobile colistin resistance genes, mcr-1 to mcr-10, and their variants have been identified, posing a new threat to the treatment of clinical infections caused by Gram-negative bacteria.
Xinran Gong, Xinran Gong, Guang Yang, Wei Liu, Di Wu, Di Wu, Di Wu, Chunyuan Duan, Chunyuan Duan, Xinjing Jia, Xinjing Jia, Zhiqiang Li, Zhiqiang Li, Zhiqiang Li, Xiaocang Zou, Renfeng Yu, Dayang Zou, Yong Wang, Yong Wang   +18 more
exaly   +3 more sources

Occurrence of Mobile Colistin Resistance Genes mcr-1–mcr-10 including Novel mcr Gene Variants in Different Pathotypes of Porcine Escherichia coli Isolates Collected in Germany from 2000 to 2021

Applied Microbiology, 2023
In the European Union, gastrointestinal disease in pigs is the main indication for the use of colistin, but large-scale epidemiologic data concerning the frequency of mobile colistin resistance (mcr) genes in pig-associated pathotypes of Escherichia coli
Lisa Göpel, Ellen Prenger-Berninghoff, Silver A. Wolf, Torsten Semmler, Rolf Bauerfeind, Christa Ewers   +5 more
doaj   +1 more source

The occurrence and molecular detection of mcr-1 and mcr-5 genes in Enterobacteriaceae isolated from poultry and poultry meats in Malaysia

Frontiers in Microbiology, 2023
The advent of antimicrobials-resistant (AMR), including colistin-resistant bacteria, poses a significant challenge to animal and human health, food safety, socio-economic growth, and the global environment.
Md Rezaul Karim, Md Rezaul Karim, Zunita Zakaria, Zunita Zakaria, Latiffah Hassan, Nik Mohd Faiz, Nur Indah Ahmad   +6 more
doaj   +1 more source