Results 11 to 20 of about 1,695,806 (215)

Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs [PDF]

BMC Research Notes, 2018
Objective Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3,
Jilei Zhang, Li Chen, Jiawei Wang, Patrick Butaye, Ke Huang, Haixiang Qiu, Xiaomei Zhang, Weijuan Gong, Chengming Wang   +8 more
doaj   +4 more sources

Phenotypic and genotypic characterization of colistin-resistant Escherichia Coli with mcr-4, mcr-5, mcr-6, and mcr-9 genes from broiler chicken and farm environment

BMC Microbiology, 2023
Background Colistin is an antibiotic used as a last-resort to treat multidrug-resistant Gram-negative bacterial infections. Colistin had been used for a long time in veterinary medicine for disease control and as a growth promoter in food-producing ...
Mulu Lemlem, Erkihun Aklilu, Maizan Mohamed, Nor Fadhilah Kamaruzzaman, Zunita Zakaria, Azian Harun, Susmita Seenu Devan, Intan Noor Aina Kamaruzaman, Mohd Farhan Hanif Reduan, Muthupandian Saravanan   +9 more
doaj   +4 more sources

Culture-Independent Quantitative PCR Detected Mobilized Colistin Resistance Genes (mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5) in Chicken Gut Contents in Bangladesh

Sci
Inappropriate antimicrobial use in food animal farming propels antimicrobial resistance (AMR) that affects all health domains. Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being ...
Mamun Al Asad, Md Sarower Hossen Shuvo, Shomaia Yasmin Mitu, Sumia, Md Asief Hossain Zihadi, Ayasha Siddique Shanta, Nahidul Islam, Shamsun Nahar, Brian Godman, Salequl Islam   +9 more
doaj   +5 more sources

Mobile Colistin-Resistant Genes mcr-1, mcr-2, and mcr-3 Identified in Diarrheal Pathogens among Infants, Children, and Adults in Bangladesh: Implications for the Future

Antibiotics
Colistin is a last-resort antimicrobial for treating multidrug-resistant Gram-negative bacteria. Phenotypic colistin resistance is highly associated with plasmid-mediated mobile colistin resistance (mcr) genes.
Shafiuzzaman Sarker, Reeashat Muhit Neeloy, Marnusa Binte Habib, Umme Laila Urmi, Mamun Al Asad, Abu Syed Md. Mosaddek, Mohammad Rabiul Karim Khan, Shamsun Nahar, Brian Godman, Salequl Islam   +9 more
doaj   +6 more sources

Dissemination of the mcr-1 colistin resistance gene [PDF]

The Lancet Infectious Diseases, 2016
Plasmid-mediated transferable colistin resistance encoded by the mcr-1 gene was described in Escherichia coli and Klebsiella pneumoniae isolates from pigs and chicken at a prevalence of around 20%, and in clinical isolates from human beings at a prevalence of around 1% in China.1 The prevalence of the mcr-1 gene in Enterobacteriaceae in other countries
Hattie E, Webb, Sophie A, Granier, Muriel, Marault, Yves, Millemann, Henk C, den Bakker, Kendra K, Nightingale, Marie, Bugarel, Sarah A, Ison, H Morgan, Scott, Guy H, Loneragan   +9 more
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Involvement of hpap2 and dgkA Genes in Colistin Resistance Mediated by mcr Determinants

Antibiotics, 2020
Plasmid-mediated colistin resistance (mcr) determinants are challenging the efficacy of polymyxins against Gram-negative pathogens. Among 10 mcr genes described so far, the major determinants mcr-1 and mcr-3 are found closely linked to hpap2 or dgkA ...
Alejandro Gallardo, María Ugarte-Ruiz, Marta Hernández, Pedro Miguela-Villoldo, David Rodríguez-Lázaro, Lucas Domínguez, Alberto Quesada   +6 more
doaj   +2 more sources

Characterisation of mobile colistin resistance genes (mcr-3 and mcr-5) in river and storm water in regions of the Western Cape of South Africa [PDF]

Antimicrobial Resistance and Infection Control, 2021
Background Colistin is regarded as a last-resort antimicrobial against multi-drug resistant Gram-negative bacteria (GNB), therefore the dissemination of colistin resistance in the environment is of great concern.
Yolandi Snyman, Andrew C. Whitelaw, Jo M. Barnes, Motlatji R. B. Maloba, Mae Newton-Foot   +4 more
doaj   +2 more sources

Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli [PDF]

Frontiers in Microbiology, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Christa Ewers, Lisa Göpel, Ellen Prenger-Berninghoff, Torsten Semmler, Katharina Kerner, Rolf Bauerfeind   +5 more
doaj   +2 more sources

First reported detection of the mobile colistin resistance genes, mcr-8 and mcr-9, in the Irish environment [PDF]

Science of The Total Environment, 2023
The emergence and dissemination of mobile colistin resistance (mcr) genes across the globe poses a significant threat to public health, as colistin remains one of the last line treatment options for multi-drug resistant infections. Environmental samples (
Morris, Dearbháile, Niall Delappe, Delappe, Niall, Brigid Hooban, Cahill, Niamh, Dearbháile Morris, Liam Burke, Cormican, Martin, O'Connor, Louise, Chueiri, Alexandra, Montserrat Gutierrez, Hooban, Brigid, Francesca McDonagh, Catherine Burgess, Burke, Liam, Louise O'Connor, Maeve Louise Farrell, Burgess, Catherine, Wendy Brennan, McDonagh, Francesca, Prendergast, Deirdre, Georgios Miliotis, Kelly Fitzhenry, Joyce, Aoife, Miliotis, Georgios, Farrell, Maeve Louise, Deirdre Prendergast, Martin Cormican, Alexandra Chueiri, Fitzhenry, Kelly, Brennan, Wendy, Aoife Joyce, Niamh Cahill, Bray, James, Gutierrez, Montserrat, James E. Bray   +35 more
core   +4 more sources

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry [PDF]

Scientific Reports, 2018
Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339
Yaoyao Wang, Li, Min, Feng Yang, Wang, Jiawei, Kelly, Patrick, You, Jinfeng, Ping Jiang, Yuan Kang, Chen, Li, Weina Guo, Stuart Price, Jing Li, Zhixing Feng, Wang, Yaoyao, Price, Stuart, Min Li, Guo, Weina, Qi, Kezong, Yassin, Afrah Kamal, Kang, Yuan, Patrick Kelly, Jilei Zhang, Jinfeng You, Gong, Jiansen, Patrick Butaye, Jiansen Gong, Jiawei Wang, Butaye, Patrick, Li, Jing, Jiang, Ping, Song, Chunlian, Chunlian Song, Kezong Qi, Zhang, Jilei, Afrah Kamal Yassin, Feng, Zhixing, Yi Yang, Li Chen, Chengming Wang, Wang, Chengming, Yang, Feng, Yang, Yi   +41 more
core   +6 more sources