Results 41 to 50 of about 1,695,806 (215)

Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome

mSystems, 2020
Extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae are critical-priority pathogens that cause substantial fatalities. With the emergence of mobile mcr genes mediating resistance to colistin in Enterobacteriaceae, clinicians are now left ...
John Osei Sekyere, Nontuthuko E. Maningi, Lesedi Modipane, Nontombi Marylucy Mbelle   +3 more
doaj   +3 more sources

Mobile Colistin Resistance (mcr) Gene-Containing Organisms in Poultry Sector in Low- and Middle-Income Countries: Epidemiology, Characteristics, and One Health Control Strategies

Antibiotics, 2023
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded genes that threaten the clinical utility of colistin (COL), one of the highest-priority critically important antibiotics (HP-CIAs) used to treat infections caused by multidrug ...
Madubuike Umunna Anyanwu, Ishmael Festus Jaja, Charles Odilichukwu R. Okpala, Emmanuel Okechukwu Njoga, Nnenna Audrey Okafor, James Wabwire Oguttu   +5 more
doaj   +1 more source

Low Level of Colistin Resistance and mcr Genes Presence in Salmonella spp.: Evaluation of Isolates Collected between 2000 and 2020 from Animals and Environment

Antibiotics, 2022
Salmonellosis is one of the most important zoonoses in Europe and the world. Human infection may evolve in severe clinical diseases, with the need for hospitalization and antimicrobial treatment.
Fabrizio Bertelloni, Giulia Cagnoli, Barbara Turchi, Valentina Virginia Ebani   +3 more
doaj   +1 more source

Image_3_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.png

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source

Development of a Novel mcr-6 to mcr-9 Multiplex PCR and Assessment of mcr-1 to mcr-9 Occurrence in Colistin-Resistant Salmonella enterica Isolates From Environment, Feed, Animals and Food (2011–2018) in Germany

Frontiers in Microbiology, 2020
The polymyxin antibiotic colistin has been used in decades for treatment and prevention of infectious diseases in livestock. Nowadays, it is even considered as last-line treatment option for severe human infections caused by multidrug- and carbapenem ...
Maria Borowiak, Beatrice Baumann, Jennie Fischer, Katharina Thomas, Carlus Deneke, Jens Andre Hammerl, Istvan Szabo, Burkhard Malorny   +7 more
doaj   +1 more source

More than mcr: canonical plasmid- and transposon-encoded mobilized colistin resistance genes represent a subset of phosphoethanolamine transferases

Frontiers in Cellular and Infection Microbiology, 2023
Mobilized colistin resistance genes (mcr) may confer resistance to the last-resort antimicrobial colistin and can often be transmitted horizontally. mcr encode phosphoethanolamine transferases (PET), which are closely related to chromosomally encoded ...
Ahmed Gaballa, Martin Wiedmann, Laura M. Carroll, Laura M. Carroll, Laura M. Carroll, Laura M. Carroll   +5 more
doaj   +1 more source

Image_2_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.pdf

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source

Epidemiology and Traits of Mobile Colistin Resistance (mcr) Gene-Bearing Organisms from Horses

Microorganisms, 2022
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) threaten the efficacy of colistin (COL), a polymyxin antibiotic that is used as a last-line agent for the treatment of deadly infections caused by multidrug-resistant and extensively drug-resistant
Madubuike Umunna Anyanwu, Ishmael Festus Jaja, Obichukwu Chisom Nwobi, Anthony Christian Mgbeahuruike, Chinaza Nnenna Ikpendu, Nnenna Audrey Okafor, James Wabwire Oguttu   +6 more
doaj   +1 more source

Data_Sheet_1_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.pdf

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source

Epidemiology of mobile colistin resistance (mcr) genes in aquatic environments

Journal of Global Antimicrobial Resistance, 2021
Colistin is one of the last-line therapies against multidrug-resistant Gram-negative pathogens, especially carbapenemase-producing isolates, making resistance to this compound a major global public-health crisis. Until recently, colistin resistance in Gram-negative bacteria was known to arise only by chromosomal mutations.
Cherak, Zineb, Loucif, Lotfi, Moussi, Abdelhamid, Rolain, Jean-Marc   +3 more
openaire   +4 more sources