Results 21 to 30 of about 3,785,189 (191)

Outer membrane permeability of mcr-positive bacteria reveals potent synergy of colistin and macromolecular antibiotics against colistin-resistant Acinetobacter baumannii [PDF]

Frontiers in Microbiology
Colistin (CT) is the last-resort of antibiotic against multidrug-resistance (MDR) Acinetobacter baumannii (A. baumannii) infection. However, colistin resistance is increasingly reported in A.
Meisong Li, Furong Ma, Hui Zhao, Dianrong Zhou, Dianrong Zhou, Dianrong Zhou, Lujie Liang, Lujie Liang, Lujie Liang, Runling Lv, Jiachen Li, Jiachen Li, Jiachen Li, Yaxuan Wang, Yaxuan Wang, Yaxuan Wang, Lin Xu, Lin Xu, Lin Xu, Chenfei Liu, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Siyuan Feng, Siyuan Feng, Siyuan Feng, Yong Xia   +26 more
doaj   +2 more sources

A Review on Colistin Resistance: An Antibiotic of Last Resort

Microorganisms
Antibiotic resistance has emerged as a significant global public health issue, driven by the rapid adaptation of microorganisms to commonly prescribed antibiotics.
Aftab Hossain Mondal, Kriti Khare, Prachika Saxena, Parbati Debnath, Kasturi Mukhopadhyay, Dhananjay Yadav   +5 more
doaj   +2 more sources

Is Africa ready for mobile colistin resistance threat? [PDF]

Infect Ecol Epidemiol, 2021
Antimicrobial resistance is a growing public health problem and a threat to effective treatment and prevention of an array of infections caused by bacteria. Africa is already faced with many socio-economic and health crises. Many countries in Africa can seldom boast of a standardized health care facility comparable to those in developed countries. Yet,
Anyanwu MU, Jaja IF, Oguttu JW, Jaja CJ, Chah KF, Shodeinde Shoyinka V.   +5 more
europepmc   +5 more sources

Putative mobilized colistin resistance genes in the human gut microbiome [PDF]

BMC Microbiology, 2021
Abstract Background The high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin, caused by mobilized colistin resistance ( mcr ) genes, poses an unprecedented threat to human health.
Bruno G. N. Andrade, Tobias Goris, Haithem Afli, Felipe H. Coutinho, Alberto M.R. Davila, Rafael R. C. Cuadrat   +5 more
  +8 more sources

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks. [PDF]

Pathogens, 2022
Background: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through mcr genes in pets.
Hamame A, Davoust B, Cherak Z, Cherak Z, Rolain JM, Diene SM.   +5 more
europepmc   +4 more sources

Detection of mobile colistin resistance genes mcr-9.1 and mcr-10.1 in Enterobacter asburiae from Ecuadorian children. [PDF]

Microbiol Resour Announc
Colistin is one of the last-line treatments for multi-drug resistant Gram-negative bacterial infections. The emergence of mobile colistin resistance genes has driven global concern and triggered the need for surveillance.
Cifuentes SG, Graham J, Trueba G, Cádenas PA.   +3 more
europepmc   +2 more sources

Identification of novel mobile colistin resistance gene mcr-10. [PDF]

Emerg Microbes Infect, 2020
Mobile colistin resistance (mcr) genes represent an emerging challenge. Here we describe a novel mcr gene, mcr-10, on an IncFIA plasmid of an Enterobacter roggenkampii clinical strain. mcr-10 has the highest nucleotide identity (79.69%) with mcr-9 and encodes MCR-10 with 82.93% amino acids identical to MCR-9.
Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z.   +5 more
europepmc   +5 more sources

The surveillance of colistin resistance and mobilized colistin resistance genes in multidrug-resistant Enterobacteriaceae isolated in Japan

International Journal of Antimicrobial Agents, 2022
The plasmid-mediated bacterial colistin-resistant gene, mcr, is of global concern in clinical healthcare. However, there are few reports of surveillance for mcr in Japan. The aim of this study was to assess the prevalence of colistin resistance by identifying nine mcr genes in extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and ...
Yasuhide Kawamoto, Norihito Kaku, Norihiko Akamatsu, Kei Sakamoto, Kosuke Kosai, Yoshitomo Morinaga, Norio Ohmagari, Koichi Izumikawa, Yoshihiro Yamamoto, Hiroshige Mikamo, Mitsuo Kaku, Kazunori Oishi, Katsunori Yanagihara   +12 more
openaire   +2 more sources

Mobile colistin resistance (mcr) genes and recent developments in colistin resistance detection

Letters in Applied Microbiology, 2023
Abstract The peptide antibiotic colistin has been reserved as a last resort antibiotic treatment option for cases where other antibiotics including carbapenems have failed. Recent emergence of colistin resistance and discovery of mobile colistin resistance (mcr) genes, which encode the cell wall modifying phosphoethanolamine transferase ...
Divya Lakshmanan, Dhamodharan Ramasamy, Veni Subramanyam, Suresh Kumar Saravanan   +3 more
openaire   +2 more sources

Epidemiology and Traits of Mobile Colistin Resistance (mcr) Gene-Bearing Organisms from Horses. [PDF]

Microorganisms, 2022
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) threaten the efficacy of colistin (COL), a polymyxin antibiotic that is used as a last-line agent for the treatment of deadly infections caused by multidrug-resistant and extensively drug-resistant bacteria in humans and animals.
Anyanwu MU, Jaja IF, Nwobi OC, Mgbeahuruike AC, Ikpendu CN, Okafor NA, Oguttu JW.   +6 more
europepmc   +4 more sources