Results 21 to 30 of about 3,600,199 (198)

Colistin resistance in ESBL- and Carbapenemase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Cambodia

Journal of Global Antimicrobial Resistance
: Objectives: Despite the critical importance of colistin as a last-resort antibiotic, limited studies have investigated colistin resistance in human infections in Cambodia.
Mallorie Hide, Soda Meng, Sokleaph Cheng, Anne-Laure Bañuls, Santy KY, Chantana YAY, Denis Laurent, Gauthier Delvallez   +7 more
doaj   +2 more sources

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks. [PDF]

Pathogens, 2022
Background: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through mcr genes in pets.
Hamame A, Davoust B, Cherak Z, Cherak Z, Rolain JM, Diene SM.   +5 more
europepmc   +4 more sources

A Review of Resistance to Polymyxins and Evolving Mobile Colistin Resistance Gene (mcr) among Pathogens of Clinical Significance. [PDF]

Antibiotics (Basel), 2023
The global rise in antibiotic resistance in bacteria poses a major challenge in treating infectious diseases. Polymyxins (e.g., polymyxin B and colistin) are last-resort antibiotics against resistant Gram-negative bacteria, but the effectiveness of polymyxins is decreasing due to widespread resistance among clinical isolates. The aim of this literature
Shahzad S, Willcox MDP, Rayamajhee B.
europepmc   +4 more sources

Identification and characterization of plasmids carrying the mobile colistin resistance gene mcr-1 using optical DNA mapping. [PDF]

JAC Antimicrob Resist, 2023
OBJECTIVES: Colistin is a last-resort antibiotic, but there has been a rapid increase in colistin resistance, threatening its use in the treatment of infections with carbapenem-resistant Enterobacterales (CRE).
Kk S, Wranne MS, Sewunet T, Ekedahl E, Coorens M, Tangkoskul T, Thamlikitkul V, Giske CG, Westerlund F.   +8 more
europepmc   +2 more sources

Identification of novel mobile colistin resistance gene mcr-10. [PDF]

Emerg Microbes Infect, 2020
Mobile colistin resistance (mcr) genes represent an emerging challenge. Here we describe a novel mcr gene, mcr-10, on an IncFIA plasmid of an Enterobacter roggenkampii clinical strain. mcr-10 has the highest nucleotide identity (79.69%) with mcr-9 and encodes MCR-10 with 82.93% amino acids identical to MCR-9.
Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z.   +5 more
europepmc   +5 more sources

The surveillance of colistin resistance and mobilized colistin resistance genes in multidrug-resistant Enterobacteriaceae isolated in Japan

International Journal of Antimicrobial Agents, 2022
The plasmid-mediated bacterial colistin-resistant gene, mcr, is of global concern in clinical healthcare. However, there are few reports of surveillance for mcr in Japan. The aim of this study was to assess the prevalence of colistin resistance by identifying nine mcr genes in extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and ...
Yasuhide Kawamoto, Norihito Kaku, Norihiko Akamatsu, Kei Sakamoto, Kosuke Kosai, Yoshitomo Morinaga, Norio Ohmagari, Koichi Izumikawa, Yoshihiro Yamamoto, Hiroshige Mikamo, Mitsuo Kaku, Kazunori Oishi, Katsunori Yanagihara   +12 more
openaire   +2 more sources

Mobile colistin resistance (mcr) genes and recent developments in colistin resistance detection

Letters in Applied Microbiology, 2023
Abstract The peptide antibiotic colistin has been reserved as a last resort antibiotic treatment option for cases where other antibiotics including carbapenems have failed. Recent emergence of colistin resistance and discovery of mobile colistin resistance (mcr) genes, which encode the cell wall modifying phosphoethanolamine transferase ...
Divya Lakshmanan, Dhamodharan Ramasamy, Veni Subramanyam, Suresh Kumar Saravanan   +3 more
openaire   +2 more sources

Epidemiology and Traits of Mobile Colistin Resistance (mcr) Gene-Bearing Organisms from Horses. [PDF]

Microorganisms, 2022
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) threaten the efficacy of colistin (COL), a polymyxin antibiotic that is used as a last-line agent for the treatment of deadly infections caused by multidrug-resistant and extensively drug-resistant bacteria in humans and animals.
Anyanwu MU, Jaja IF, Nwobi OC, Mgbeahuruike AC, Ikpendu CN, Okafor NA, Oguttu JW.   +6 more
europepmc   +4 more sources

Mobile Colistin Resistance Enzyme MCR-3 Facilitates Bacterial Evasion of Host Phagocytosis. [PDF]

Adv Sci (Weinh), 2021
AbstractMobile colistin resistance enzyme MCR‐3 is a phosphoethanolamine transferase modifying lipid A in Gram‐negative bacteria. MCR‐3 generally mediates low‐level (≤8 mg L−1) colistin resistance among Enterobacteriaceae, but occasionally confers high‐level (>128 mg L−1) resistance in aeromonads.
Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR, Dai C, Li J, Yang H, Liu D, Wang Y, Gao GF, Shen J.   +16 more
europepmc   +5 more sources

An overview of colistin resistance, mobilized colistin resistance genes dissemination, global responses, and the alternatives to colistin: A review [PDF]

Veterinary World, 2019
Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide dissemination of colistin-resistance has brought strong attention to the scientific society because of its importance as the last resort for the treatment of carbapenem-
Mohammad H. Gharaibeh, Shoroq Q. Shatnawi   +1 more
openaire   +3 more sources