Results 31 to 40 of about 3,785,189 (191)

An overview of colistin resistance, mobilized colistin resistance genes dissemination, global responses, and the alternatives to colistin: A review [PDF]

Veterinary World, 2019
Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide dissemination of colistin-resistance has brought strong attention to the scientific society because of its importance as the last resort for the treatment of carbapenem-
Mohammad H. Gharaibeh, Shoroq Q. Shatnawi   +1 more
openaire   +3 more sources

Transmission of Mobile Colistin Resistance (mcr-1) by Duodenoscope. [PDF]

Clin Infect Dis, 2019
Clinicians increasingly utilize polymyxins for treatment of serious infections caused by multidrug-resistant gram-negative bacteria. Emergence of plasmid-mediated, mobile colistin resistance genes creates potential for rapid spread of polymyxin resistance.
Shenoy ES, Pierce VM, Walters MS, Moulton-Meissner H, Lawsin A, Lonsway D, Shugart A, McAllister G, Halpin AL, Zambrano-Gonzalez A, Ryan EE, Suslak D, DeJesus A, Barton K, Madoff LC, McHale E, DeMaria A, Hooper DC.   +17 more
europepmc   +3 more sources

The Mobile Colistin Resistance Gene, mcr-1.1, Is Carried on IncX4 Plasmids in Multidrug Resistant E. coli Isolated from Rainbow Trout Aquaculture. [PDF]

Microorganisms, 2020
Colistin, a last resort antibiotic, is important for controlling infections with carbapenem-resistant Enterobacteriaceae. The recent emergence of mobile-colistin-resistance (mcr) genes has threatened the effectiveness of colistin.
Hassan J, Eddine RZ, Mann D, Li S, Deng X, Saoud IP, Kassem II.   +6 more
europepmc   +2 more sources

Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018) [PDF]

Microorganisms, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways ...
Mohammed Elbediwi, Yan Li, Narayan Paudyal, Hang Pan, Xiaoliang Li, Shaohua Xie, Andreja Rajkovic, Youjun Feng, Weihuan Fang, Shelley C. Rankin, Min Yue   +10 more
openaire   +4 more sources

Mobile colistin resistance: Prevalence, mechanisms, and current detection methods

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 2022
Colistin is considered the last-line antibiotic against multidrug-resistant Gram-negative bacterial infections. The global dissemination of Mobile colistin resistance mcr-harboring bacteria is threatening public health. Such isolates have been detected in various reservoirs including animals, food products, the environment, and humans.
Nguyen Quang Truong, Le Huyen Ai Thuy, Svetlana A Egorova, Lidiia A Kaftyreva, Hoang Quoc Cuong   +4 more
openaire   +2 more sources

A Clinico-Microbiological Study of Blood Stream Infections in a Tertiary Referral Hospital: Colistin Resistance & Challenges [PDF]

, 2023
Carbapenems, frequently used for the treatment of infections caused by Multidrug-resistant (MDR) Gram-negative bacteria (GNB) are being reported with increased resistance rate.
Jyoti Chaudhary, Veenu Gupta, Samandeep Kaur   +2 more
core   +1 more source

ISEc69-Mediated Mobilization of the Colistin Resistance Gene mcr-2 in Escherichia coli [PDF]

Frontiers in Microbiology, 2021
ObjectivesThe emergence of mobile colistin resistance genes has compromised the efficacy of the last resort antibiotic, colistin, in clinical treatment. The mcr-2 gene was first identified in Belgium in association with the insertion sequence ISEc69.
Yu-Zhang He, Yu-Zhang He, Teng-Fei Long, Teng-Fei Long, Bing He, Bing He, Xing-Ping Li, Xing-Ping Li, Gong Li, Gong Li, Liang Chen, Xiao-Ping Liao, Xiao-Ping Liao, Ya-Hong Liu, Ya-Hong Liu, Jian Sun, Jian Sun   +16 more
openaire   +3 more sources

Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes [PDF]

Environmental Microbiology, 2020
Summary Colistin resistance has attracted substantial attention after colistin was considered as a last‐resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug‐resistant (MDR) Gram‐negative bacteria in clinical settings.
Yingbo Shen, Rong Zhang, Stefan Schwarz, Congming Wu, Jianzhong Shen, Timothy R. Walsh, Yang Wang   +6 more
openaire   +2 more sources

Structural‐Activity Relationship‐Inspired the Discovery of Saturated Fatty Acids as Novel Colistin Enhancers

Advanced Science, 2023
The emergence and prevalence of mobile colistin resistance gene mcr have dramatically compromised the clinical efficacy of colistin, a cyclopeptide antibiotic considered to be the last option for treating different‐to‐treat infections.
Jinju Cai, Jingru Shi, Chen Chen, Mengping He, Zhiqiang Wang, Yuan Liu   +5 more
doaj   +1 more source

Prevalence and transmission risk of colistin and multidrug resistance in long-distance coastal aquaculture

, 2023
Due to the wide use of antibiotics, intensive aquaculture farms have been recognized as a significant reservoir of antibiotic resistomes. Although the prevalence of colistin resistance genes and multidrug-resistant bacteria (MDRB) has been documented ...
Zhao, Huijun, An, Taicheng, Wong, Po Keung, Cai, Yiwei, Li, Shaoting, Guo, Jianhua, Li, Guiying   +6 more
core   +1 more source