Results 11 to 20 of about 30,353 (249)
Molecules, 2022 The emergence of the plasmid-mediated colistin resistance gene mcr-1 has resulted in the loss of available treatments for certain severe infections.
Shengnan Xie +6 more
doaj +3 more sources
Remarkable Diversity of Escherichia coli Carrying mcr-1 from Hospital Sewage with the Identification of Two New mcr-1 Variants [PDF]
Frontiers in Microbiology, 2017 The plasmid-borne colistin-resistant gene mcr-1 has rapidly become a worldwide public health concern. This study aims to determine the host bacterial strains, plasmids, and genetic contexts of mcr-1 in hospital sewage.
Feifei Zhao +9 more
doaj +3 more sources
Dissemination of the mcr-1 colistin resistance gene [PDF]
The Lancet Infectious Diseases, 2016 Plasmid-mediated transferable colistin resistance encoded by the mcr-1 gene was described in Escherichia coli and Klebsiella pneumoniae isolates from pigs and chicken at a prevalence of around 20%, and in clinical isolates from human beings at a prevalence of around 1% in China.1 The prevalence of the mcr-1 gene in Enterobacteriaceae in other countries
Yongfei, Hu +4 more
+33 more sources
Dissemination and Mechanism for the MCR-1 Colistin Resistance.
PLoS Pathogens, 2016 Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance ...
Rongsui Gao +13 more
doaj +4 more sources
Catalytic mechanism of the colistin resistance protein MCR-1 [PDF]
Organic & Biomolecular Chemistry, 2020 Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.
Reynier Suardíaz +6 more
openaire +6 more sources
Frontiers in Cellular and Infection Microbiology, 2022 The prevalence and transmission of mobile colistin resistance (mcr) genes have led to a severe threat to humans and animals. Escherichia fergusonii is an emerging pathogen which is closely related to a variety of diseases.
Ruishan Liu +8 more
doaj +1 more source
mSphere, 2020 Père David’s deer (Elaphurus davidianus or milu) is an endangered species, and the prevalence of antimicrobial resistance (AMR) such as mcr-1-positive strains among them has been unknown.
Xiaoyu Lu +5 more
doaj +1 more source
MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria
Emerging Microbes and Infections, 2022 The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human health. Recent studies by our group and others have shown that the withdrawal of colistin as a feed additive dramatically reduced the prevalence of mcr-1. Although
Siyuan Feng +15 more
doaj +1 more source
Identification of Functional Interactome of Colistin Resistance Protein MCR-1 in Escherichia coli
Frontiers in Microbiology, 2021 The emergence and worldwide dissemination of plasmid-mediated colistin resistance gene mcr-1 has attracted global attention. The MCR-1 enzyme mediated colistin resistance by catalyzing phosphoethanolamine (PEA) transfer onto bacterial lipid A.
Hui Li +7 more
doaj +1 more source
Epidemiology, genetic dynamics, and transmission of the <i>mcr-1</i> gene in China. [PDF]
Emerg Microbes InfectColistin is a broad-spectrum antibiotic that kills bacteria through the disruption of the cell membrane, making it effective against various bacterial infections. Since the first global report of mobile colistin-resistant (mcr-1)-positive bacteria, which were discovered and described by Chinese scientists in 2015, monitoring and research on these ...
Wang B +14 more
europepmc +4 more sources