Results 11 to 20 of about 30,237 (249)
Catalytic mechanism of the colistin resistance protein MCR-1 [PDF]
Organic & Biomolecular Chemistry, 2020 Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.
Reynier Suardíaz +6 more
openaire +6 more sources
Effect of Different Tolerable Levels of Constitutive mcr-1 Expression on Escherichia coli
Microbiology Spectrum, 2022 To study the effect of different tolerable levels of constitutive mcr-1 expression on Escherichia coli, and to provide direct evidence for moderate resistance mediated by mcr-1, construction of E.
Han Qiao +7 more
doaj +1 more source
Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. [PDF]
PLoS ONE, 2018 A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes.
Mark G Wise +4 more
doaj +1 more source
Microbiology Spectrum, 2023 Colistin is one of the last-resort antibiotics for treating infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, mcr genes conferring resistance to colistin have been widely identified, which is considered a global threat to ...
Xiaoyu Lu +10 more
doaj +1 more source
Microbiology Spectrum, 2022 The global dissemination of the mobile colistin resistance (mcr) gene illustrates how the use of colistin in veterinary medicine can affect human health, exemplifying the concept of One Health.
Melissa Chunjiao Liu +4 more
doaj +1 more source
Frontiers in Microbiology, 2021 We set out to study the prevalence of the mcr-1 gene in carbapenemase-producing Klebsiella pneumoniae (CPKP) strains, and to determine whether its presence is associated with a fitness cost.
Yi-Hsiang Cheng +10 more
doaj +1 more source
Chromosomally and Plasmid-Located mcr in Salmonella from Animals and Food Products in China
Microbiology Spectrum, 2022 This study aimed to investigate the prevalence and genomic characteristics of the colistin resistance gene mcr in Salmonella enterica in China. In total, 445 S. enterica isolates from animals and food products were screened through PCR and sequencing for
Cai-Yue Mei +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 The prevalence and transmission of mobile colistin resistance (mcr) genes have led to a severe threat to humans and animals. Escherichia fergusonii is an emerging pathogen which is closely related to a variety of diseases.
Ruishan Liu +8 more
doaj +1 more source
mSphere, 2020 Père David’s deer (Elaphurus davidianus or milu) is an endangered species, and the prevalence of antimicrobial resistance (AMR) such as mcr-1-positive strains among them has been unknown.
Xiaoyu Lu +5 more
doaj +1 more source
MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria
Emerging Microbes and Infections, 2022 The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human health. Recent studies by our group and others have shown that the withdrawal of colistin as a feed additive dramatically reduced the prevalence of mcr-1. Although
Siyuan Feng +15 more
doaj +1 more source