Results 31 to 40 of about 30,353 (249)

Features of the mcr-1 Cassette Related to Colistin Resistance [PDF]

Antimicrobial Agents and Chemotherapy, 2016
The recent description of the plasmid-mediated colistin resistance gene, mcr-1 , in strains isolated from food animals, food and humans in China was a signal for an avalanche of retrospective and prospective studies investigating the occurrence of this specific gene (1).…
Zurfluh, Katrin, Kieffer, Nicolas, Poirel, Laurent, Nordmann, Patrice, Stephan, Roger   +4 more
openaire   +5 more sources

Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

International Journal of Infectious Diseases, 2018
We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%)
Kuastros Mekonnen Belaynehe, Seung Won Shin, Kyung Yoon Park, Ji Young Jang, Ho Geun Won, In Joong Yoon, Han Sang Yoo   +6 more
doaj   +1 more source

The evolution of infectious transmission promotes the persistence of mcr-1 plasmids. [PDF]

mBio, 2023
ABSTRACT Conjugative plasmids play a vital role in bacterial evolution and promote the spread of antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the host bacteria. Compensatory mutations are known as an effective evolutionary solution to reduce the fitness cost and improve plasmid ...
Yang J, Wu R, Xia Q, Yu J, Yi LX, Huang Y, Deng M, He WY, Bai Y, Lv L, Burrus V, Wang C, Liu JH.   +12 more
europepmc   +4 more sources

Clinical relevance and plasmid dynamics of mcr-1-positive Escherichia coli in China: a multicentre case-control and molecular epidemiological study

The Lancet Microbe, 2020
Summary: Background: Although the emergence of the plasmid-mediated colistin resistance gene, mcr-1, caused global concern, little is known about its clinical implications and transmission characteristics over time.
Yan Jiang, PhD, Ying Zhang, PhD, Jun Lu, MS, Qihui Wang, MS, Yushan Cui, MS, Yanfei Wang, MS, Jingjing Quan, PhD, Dongdong Zhao, MD, Xiaoxing Du, MS, Haiyang Liu, MS, Xi Li, PhD, Xueqing Wu, PhD, Xiaoting Hua, PhD, Ye Feng, PhD, Yunsong Yu, ProfMD   +14 more
doaj   +1 more source

Structure of the catalytic domain of the colistin resistance enzyme MCR-1 [PDF]

BMC Biology, 2016
Due to the paucity of novel antibiotics, colistin has become a last resort antibiotic for treating multidrug resistant bacteria. Colistin acts by binding the lipid A component of lipopolysaccharides and subsequently disrupting the bacterial membrane.
Vlatko Stojanoski, Banumathi Sankaran, B. V. Venkataram Prasad, Laurent Poirel, Patrice Nordmann, Timothy Palzkill   +5 more
openaire   +6 more sources

Heterogeneous and Flexible Transmission of mcr-1 in Hospital-Associated Escherichia coli

mBio, 2018
The recent emergence of a transferable colistin resistance mechanism, MCR-1, has gained global attention because of its threat to clinical treatment of infections caused by multidrug-resistant Gram-negative bacteria.
Yingbo Shen, Zuowei Wu, Yang Wang, Rong Zhang, Hong-Wei Zhou, Shaolin Wang, Lei Lei, Mei Li, Jiachang Cai, Jonathan Tyrrell, Guo-Bao Tian, Congming Wu, Qijing Zhang, Jianzhong Shen, Timothy R. Walsh, Zhangqi Shen   +15 more
doaj   +1 more source

Global Dissemination of the mcr-1 gene

Archives of Pediatric Infectious Diseases, 2016
: Antimicrobial resistance is one of the most severe threats to human health. The first report of plasmid-mediated colistin resistance in Escherichia coli from animals, food, and humans was in 2015 from China. The current increasing trend of resistance is extremely troubling because polymyxins are the last-resort antibiotics for treating infections with
Soroor Erfanimanesh, Ali Hashemi
openaire   +1 more source

Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Since the gene encoding mobilised colistin resistance (mcr-1) was first reported in China in 2015, it has been reported in various Enterobacteriaceae worldwide.
Jing Xie, Beibei Liang, Xuebin Xu, Lang Yang, Huan Li, Peng Li, Shaofu Qiu, Hongbin Song   +7 more
doaj   +1 more source

Prevalence and antibiotic susceptibility of colistin-resistance gene (mcr-1) positive Enterobacteriaceae in stool specimens of patients attending a tertiary care hospital in Singapore

International Journal of Infectious Diseases, 2019
Objectives: The aim of this study was to determine the prevalence of the colistin-resistance gene (mcr-1) and the antibiotic-susceptibility profile of mcr-1 positive, colistin-resistant isolates in stool specimens of patients attending a tertiary care ...
My-Van La, Biondi Lee, Brian Z.M. Hong, Jing Yan Yah, Seok-Hwee Koo, Boran Jiang, Lily S.Y. Ng, Thean-Yen Tan   +7 more
doaj   +1 more source

Peptide MSI‐1 inhibited MCR‐1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli

Microbial Biotechnology, 2023
Polymyxin resistance is conferred by MCR‐1 (mobile colistin resistance 1)‐induced lipopolysaccharide (LPS) modification of G− bacteria. However, the peptide MSI‐1 exerts potent antimicrobial activity against mcr‐1‐carrying bacteria.
Xinyue Ye, Jian Wang, Pengfei Xu, Xiaoqian Yang, Qixue Shi, Genyan Liu, Zhaoshi Bai, Changlin Zhou, Lingman Ma   +8 more
doaj   +1 more source