Results 1 to 10 of about 2,895 (162)

An Investigation of Colistin Heteroresistance in <i>Klebsiella pneumoniae</i> Isolates in Iran. [PDF]

Biomed Res Int
Background According to the World Health Organization 2024 bacterial priority pathogens list, carbapenem‐resistant Enterobacterales (CRE) were listed among the critical priority pathogens. Heteroresistance (i.e., a bacterial isolate that appears susceptible but harbors resistant subpopulations) represents a challenge in traditional laboratory testing ...
Rad ZR, Rad ZR, Goudarzi H, Goudarzi M, Javidi M, Sharahi JY, Kargar M, Hashemi A.   +7 more
europepmc   +2 more sources

Species-dependent in polymyxin B heteroresistance: genomic insights into adaptive evolution in Enterobacteriaceae [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Polymyxin heteroresistance poses a growing challenge in antimicrobial resistance management, yet its epidemiological features and molecular basis across different bacterial species and environments remain poorly understood. This study aimed to
Hui Zhang, Linna Xu, Xiaofen Mo, Biao Tang, Junfeng Fan, Tingting Xiao, Qixia Luo, Fen Wan   +7 more
doaj   +2 more sources

Evaluation of Xpert MTB/XDR and Deeplex Myc-TB for the Rapid Detection of Drug Resistance in <i>Mycobacterium tuberculosis</i>. [PDF]

Int J Microbiol
Objectives Rapid identification of drug‐resistant tuberculosis remains critical for the initiation of appropriate treatment regimens, improved success rates and reduction in the development of drug resistance. In this study, we compared the diagnostic performance of two novel diagnostic tests, Xpert MTB/XDR and Deeplex Myc‐TB (both CE marked).
Park M, Solanki P, McHugh TD, Kon OM, Satta G.   +4 more
europepmc   +2 more sources

Tandem amplification of the umpA allele contributes to ceftazidime-avibactam heteroresistance in clinical carbapenem-resistant Klebsiella pneumoniae isolates [PDF]

Microbiology Spectrum
Ceftazidime-avibactam (CAZ/AVI, CZA) combination has shown promising efficacy against carbapenem-resistant Klebsiella pneumoniae (CRKP); however, several recent studies have reported resistance to CZA in CRKP.
Mengyao Wang, Ying Li, Jia Hu, Yu Zhang, Jing Yu, Feng Li, Yuqiao Han, Yuyuan Li, Tao Song, Yiling Lin, Yang Chen   +10 more
doaj   +2 more sources

Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin

Microbiology Spectrum, 2023
Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to colistin. The aim of this work was to study heteroresistance in 10 wild-type Klebsiella pneumoniae isolates of clinical origin ...
TERESA Garcia-Martinez, Irène Sanchez Leon, Luis Martinez Martinez   +2 more
exaly   +3 more sources

An investigation of gene dosage reveals that increased sensitivity to D-cycloserine divergently impacts the transience of heteroresistance in Escherichia coli [PDF]

mBio
Heteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj   +2 more sources

Two types of colistin heteroresistance in Acinetobacter baumannii isolates

Emerging Microbes and Infections, 2020
In this study, we investigated the colistin heteroresistance patterns in Acinetobacter baumannii isolates. To identify colistin heteroresistance, population analysis profiling was performed for six in vitro colistin-susceptible A.
Kwan Soo Ko, Hyunkeun Kim
exaly   +3 more sources

Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]

BMC Microbiology
Background Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong, Zhidong Hu, Ling Yang, Haifang Kong, Yuanhong Xu   +4 more
doaj   +2 more sources

Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli [PDF]

mBio
Heteroresistance is a transient resistance phenotype characterized by the presence of small subpopulations of bacterial cells with elevated antibiotic resistance within a susceptible main population.
Sheida Heidarian, Karin Hjort, Hervé Nicoloff, Dan I. Andersson   +3 more
doaj   +2 more sources

Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]

iScience
Summary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong   +3 more
doaj   +2 more sources