Results 1 to 10 of about 5,067 (154)

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity [PDF]

Clinical Microbiology Reviews, 2015
“Heteroresistance” describes a phenomenon where subpopulations of seemingly isogenic bacteria exhibit a range of susceptibilities to a particular antibiotic. Unfortunately, a lack of standard methods to determine heteroresistance has led to inappropriate
Omar M El-Halfawy, Miguel Ángel Valvano
exaly   +2 more sources

Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]

BMC Microbiology
Background Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong, Zhidong Hu, Ling Yang, Haifang Kong, Yuanhong Xu   +4 more
doaj   +2 more sources

An investigation of gene dosage reveals that increased sensitivity to D-cycloserine divergently impacts the transience of heteroresistance in Escherichia coli [PDF]

mBio
Heteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj   +2 more sources

Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli [PDF]

mBio
Heteroresistance is a transient resistance phenotype characterized by the presence of small subpopulations of bacterial cells with elevated antibiotic resistance within a susceptible main population.
Sheida Heidarian, Karin Hjort, Hervé Nicoloff, Dan I. Andersson   +3 more
doaj   +2 more sources

Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]

iScience
Summary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong   +3 more
doaj   +2 more sources

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study [PDF]

Emerging Microbes and Infections
Mixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes.
Yanping Liu, Yangyi Zhang, Xiaoyu Lu, Zheyuan Wu, Minjuan Li, Rui Zhang, Yixiao Lu, Renjie Hou, Yating Ji, Qingping Zhang, Qi Jiang, Jing Li, Yuan Jiang, Yunxia Wang, Jianhui Yuan, Howard E. Takiff, Xin Chen, Xin Shen, Chongguang Yang   +18 more
doaj   +2 more sources

Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression [PDF]

BMC Microbiology
Background Salmonella enterica Serovar Typhimurium (S. Typhimurium) is a major global foodborne pathogen. In our previous study, the S. Typhimurium ATCC 14028 strain harboring plasmid pHXY0908 survived at fourfold its ciprofloxacin MIC (MIC0908 = 0.125 ...
Mengyuan Li, Xiaoyin Feng, Qianting Jian, Mou Jing, Xiran Wang, Zehua Cui, Rongmin Zhang, Jian Sun, Yahong Liu, Xiaoping Liao, Xinlei Lian   +10 more
doaj   +2 more sources

MexS mediated heteroresistance of Pseudomonas aeruginosa to ciprofloxacin [PDF]

Frontiers in Microbiology
Bacterial heteroresistance has been increasingly identified as an important phenomenon for many antibiotic/bacterium combinations. However the mechanisms underlying ciprofloxacin heteroresistance in P.
Xiaodan Ma, Xiaodan Ma, Yana Chen, Chenlu Xiao, Chenlu Xiao, Congcong Li, Lizhong Han, Lizhong Han, Chengxi Li, Chengxi Li, Jinjing Ni   +10 more
doaj   +2 more sources

Investigation of voriconazole heteroresistance in clinical isolates of Trichosporon asahii from a multicenter study in China [PDF]

Microbiology Spectrum
Heteroresistance refers to the presence of subpopulations within seemingly homogeneous microbial cells that exhibit varying sensitivities to antifungal agents, potentially contributing to treatment failure.
Chenlu Liu, Qiaoying Gao, Yingxing Li, Jinhan Yu, Shuying Yu, Xinfei Chen, Xue Li, Yingchun Xu, Ying Zhao, Lina Guo   +9 more
doaj   +2 more sources

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K ...
Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen   +5 more
doaj   +2 more sources