Insight Into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Journal of Fungi (Basel, Switzerland)Antifungal resistance poses a critical global health threat, particularly in immuno-compromised patients. Beyond the traditional resistance mechanisms rooted in heritable and stable mutations, a distinct phenomenon known as heteroresistance has been ...
Tianshu Sun, Yingxing Li
exaly +6 more sources
Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains [PDF]
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2017 Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported.
Deniz GAZEL, Müşerref TATMAN OTKUN
doaj +5 more sources
MexS mediated heteroresistance of Pseudomonas aeruginosa to ciprofloxacin [PDF]
Frontiers in MicrobiologyBacterial heteroresistance has been increasingly identified as an important phenomenon for many antibiotic/bacterium combinations. However the mechanisms underlying ciprofloxacin heteroresistance in P.
Xiaodan Ma +10 more
doaj +5 more sources
Journal of Medical Microbiology and Infectious Diseases, 2021 Introduction: Heteroresistance is the phenomenon wherein subpopulations of microbes exhibit a range of resistance to an antibiotic and are prevalent in a broad range of microorganisms.
Mohammad Taha Ebrahimi +4 more
doaj +2 more sources
Annals of Clinical Microbiology and Antimicrobials, 2022 Background Antimicrobial resistance of H. pylori can lead to treatment failure. Importantly, several studies have reported on heteroresistance, i.e. the presence of resistant and susceptible H. pylori populations in the same sample and/or a difference in
Ebrahim Kouhsari +7 more
doaj +2 more sources
Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis. [PDF]
PLoS ONE, 2017 Amplicon-based Next Generation Sequencing (NGS) is an emerging method for Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well described. We examined 158 clinical multidrug-resistant M.
Darwin J Operario +12 more
doaj +3 more sources
Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli [PDF]
mBioHeteroresistance is a transient resistance phenotype characterized by the presence of small subpopulations of bacterial cells with elevated antibiotic resistance within a susceptible main population.
Sheida Heidarian +3 more
doaj +2 more sources
Heterogeneity in the response to the metabolic environment drives fosfomycin heteroresistance [PDF]
Nature CommunicationsHeteroresistance is a form of antibiotic resistance in which a phenotypically unstable subpopulation of resistant cells coexists with a majority susceptible population.
Jacob E. Choby +6 more
doaj +2 more sources
Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression [PDF]
BMC MicrobiologyBackground Salmonella enterica Serovar Typhimurium (S. Typhimurium) is a major global foodborne pathogen. In our previous study, the S. Typhimurium ATCC 14028 strain harboring plasmid pHXY0908 survived at fourfold its ciprofloxacin MIC (MIC0908 = 0.125 ...
Mengyuan Li +10 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundAntimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and ...
You-hua Wang +7 more
doaj +1 more source