Results 11 to 20 of about 3,808 (178)

Heteroresistance in Mycobacterium tuberculosis: from molecular mechanisms and advanced detection to clinical implications [PDF]

Frontiers in Cellular and Infection Microbiology
Drug resistance in Mycobacterium species, particularly Mycobacterium tuberculosis, remains a protracted and severe challenge to global public health.
Shibo Liu, Dan Chen, Juanjue Zhang, Mingli Zhu   +3 more
doaj   +3 more sources

Antibiotic Heteroresistance in Klebsiella pneumoniae

International Journal of Molecular Sciences, 2021
Klebsiella pneumoniae is one of the most common pathogens responsible for infections, including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence of multidrug-resistant K. pneumoniae was recognized in 2017 by the World Health Organization as a critical public health threat.
Karolina Stojowska-Swędrzyńska, Adrianna Łupkowska, Dorota Kuczyńska-Wiśnik, Ewa Laskowska   +3 more
openaire   +3 more sources

Heteroresistance to penicillin in Streptococcus pneumoniae [PDF]

Proceedings of the National Academy of Sciences, 2007
Heteroresistance to β-lactam antibiotics has been mainly described for staphylococci, for which it complicates diagnostic procedures and therapeutic success. This study investigated whether heteroresistance to penicillin exists in Streptococcus pneumoniae .
Morand, Brigitte, Mühlemann, Kathrin
openaire   +5 more sources

Heteroresistance: a concern of increasing clinical significance? [PDF]

Clinical Microbiology and Infection, 2008
Recent studies have focused on issues related to heteroresistance, including its definition, methods of detection and frequency. Most such studies have reported data concerning infections caused by Staphylococcus aureus, but the clinical significance of heteroresistance is unclear. Six studies have described infections caused by S.
Falagas, M.E., Makris, G.C., Dimopoulos, G., Matthaiou, D.K.   +3 more
core   +7 more sources

Analysis of β-lactams and Carbapenem Heteroresistance in Extra-intestinal Pathogenic Escherichia coli from Blood Samples in Iran

Journal of Medical Microbiology and Infectious Diseases, 2021
Introduction: Heteroresistance is the phenomenon wherein subpopulations of microbes exhibit a range of resistance to an antibiotic and are prevalent in a broad range of microorganisms.
Mohammad Taha Ebrahimi, Mohsen Nazari, Niloofar Mobarezpour, Hamed Afkhami, Sepideh Fereshteh   +4 more
doaj   +2 more sources

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis. [PDF]

PLoS ONE, 2017
Amplicon-based Next Generation Sequencing (NGS) is an emerging method for Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well described. We examined 158 clinical multidrug-resistant M.
Darwin J Operario, Alexander F Koeppel, Stephen D Turner, Yongde Bao, Suporn Pholwat, Sayera Banu, Suporn Foongladda, Stellah Mpagama, Jean Gratz, Oleg Ogarkov, Svetlana Zhadova, Scott K Heysell, Eric R Houpt   +12 more
doaj   +3 more sources

Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease [PDF]

Frontiers in Microbiology, 2023
Antibiotic resistance is a major Public Health challenge worldwide. Mechanisms other than resistance are described as contributors to therapeutic failure.
Celia Gil-Campillo, Celia Gil-Campillo, Celia Gil-Campillo, Aida González-Díaz, Aida González-Díaz, Beatriz Rapún-Araiz, Beatriz Rapún-Araiz, Oihane Iriarte-Elizaintzin, Iris Elizalde-Gutiérrez, Ariadna Fernández-Calvet, María Lázaro-Díez, Sara Martí, Sara Martí, Junkal Garmendia, Junkal Garmendia, Junkal Garmendia   +15 more
doaj   +2 more sources

Reaction Kinetic Models of Antibiotic Heteroresistance [PDF]

International Journal of Molecular Sciences, 2019
Bacterial heteroresistance (i.e., the co-existence of several subpopulations with different antibiotic susceptibilities) can delay the clearance of bacteria even with long antibiotic exposure. Some proposed mechanisms have been successfully described with mathematical models of drug-target binding where the mechanism’s downstream of drug-target binding
Antal Martinecz, Fabrizio Clarelli, Sören Abel, Pia Abel zur Wiesch   +3 more
openaire   +5 more sources

Heteroresistance to clarithromycin and metronidazole in patients with a Helicobacter pylori infection: a systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Antimicrobial resistance of H. pylori can lead to treatment failure. Importantly, several studies have reported on heteroresistance, i.e. the presence of resistant and susceptible H. pylori populations in the same sample and/or a difference in
Ebrahim Kouhsari, Nourkhoda Sadeghifard, Arezoo Khadiv, Hojjat Sayadi, Taghi Amiriani, Sobhan Ghafourian, Hassan Valadbeigi, Marcela Krutova   +7 more
doaj   +2 more sources

Vancomycin Heteroresistance in Staphylococcus Haemolyticus : Elusive Phenotype

Future Science OA, 2021
To determine the presence of vancomycin heteroresistance in Staphylococcus haemolyticus.A total of 48 rifampicin-resistant S. haemolyticus isolates from bloodstream infections were included. Vancomycin heteroresistance was determined using the population analysis profile-area under curve (PAP-AUC) method. All the isolates were screened for the presence
Yamuna Devi Bathavatchalam, Dhanalakshmi Solaimalai, Anushree Amladi, Hariharan Triplicane Dwarakanathan, Shalini Anandan, Balaji Veeraraghavan   +5 more
openaire   +4 more sources