Results 11 to 20 of about 3,479 (180)

An Investigation of Colistin Heteroresistance in <i>Klebsiella pneumoniae</i> Isolates in Iran. [PDF]

Biomed Res Int
Background According to the World Health Organization 2024 bacterial priority pathogens list, carbapenem‐resistant Enterobacterales (CRE) were listed among the critical priority pathogens. Heteroresistance (i.e., a bacterial isolate that appears susceptible but harbors resistant subpopulations) represents a challenge in traditional laboratory testing ...
Rad ZR, Rad ZR, Goudarzi H, Goudarzi M, Javidi M, Sharahi JY, Kargar M, Hashemi A.   +7 more
europepmc   +2 more sources

Evaluation of Xpert MTB/XDR and Deeplex Myc-TB for the Rapid Detection of Drug Resistance in <i>Mycobacterium tuberculosis</i>. [PDF]

Int J Microbiol
Objectives Rapid identification of drug‐resistant tuberculosis remains critical for the initiation of appropriate treatment regimens, improved success rates and reduction in the development of drug resistance. In this study, we compared the diagnostic performance of two novel diagnostic tests, Xpert MTB/XDR and Deeplex Myc‐TB (both CE marked).
Park M, Solanki P, McHugh TD, Kon OM, Satta G.   +4 more
europepmc   +2 more sources

Heteroresistance to clarithromycin and metronidazole in patients with a Helicobacter pylori infection: a systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Antimicrobial resistance of H. pylori can lead to treatment failure. Importantly, several studies have reported on heteroresistance, i.e. the presence of resistant and susceptible H. pylori populations in the same sample and/or a difference in
Ebrahim Kouhsari, Nourkhoda Sadeghifard, Arezoo Khadiv, Hojjat Sayadi, Taghi Amiriani, Sobhan Ghafourian, Hassan Valadbeigi, Marcela Krutova   +7 more
doaj   +2 more sources

Reaction Kinetic Models of Antibiotic Heteroresistance [PDF]

International Journal of Molecular Sciences, 2019
Bacterial heteroresistance (i.e., the co-existence of several subpopulations with different antibiotic susceptibilities) can delay the clearance of bacteria even with long antibiotic exposure.
Martinecz, Antal, Abel, Sören, Clarelli, Fabrizio, Fabrizio Clarelli, Sören Abel, Abel zur Wiesch, Pia, Antal Martinecz, Pia Abel zur Wiesch   +7 more
core   +5 more sources

Tandem amplification of the umpA allele contributes to ceftazidime-avibactam heteroresistance in clinical carbapenem-resistant Klebsiella pneumoniae isolates [PDF]

Microbiology Spectrum
Ceftazidime-avibactam (CAZ/AVI, CZA) combination has shown promising efficacy against carbapenem-resistant Klebsiella pneumoniae (CRKP); however, several recent studies have reported resistance to CZA in CRKP.
Mengyao Wang, Ying Li, Jia Hu, Yu Zhang, Jing Yu, Feng Li, Yuqiao Han, Yuyuan Li, Tao Song, Yiling Lin, Yang Chen   +10 more
doaj   +2 more sources

Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin

Microbiology Spectrum, 2023
Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to colistin. The aim of this work was to study heteroresistance in 10 wild-type Klebsiella pneumoniae isolates of clinical origin ...
Elena Perez-Nadales, TERESA Garcia-Martinez, Luis Martínez-Martínez   +2 more
exaly   +3 more sources

Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]

BMC Microbiology
Background Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong, Zhidong Hu, Ling Yang, Haifang Kong, Yuanhong Xu   +4 more
doaj   +2 more sources

An investigation of gene dosage reveals that increased sensitivity to D-cycloserine divergently impacts the transience of heteroresistance in Escherichia coli [PDF]

mBio
Heteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj   +2 more sources

Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]

iScience
Summary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong   +3 more
doaj   +2 more sources

Two types of colistin heteroresistance in Acinetobacter baumannii isolates

Emerging Microbes and Infections, 2020
In this study, we investigated the colistin heteroresistance patterns in Acinetobacter baumannii isolates. To identify colistin heteroresistance, population analysis profiling was performed for six in vitro colistin-susceptible A.
Yoon-Kyoung Hong, Hyunkeun Kim, Kwan Soo Ko   +2 more
exaly   +3 more sources