Heteroresistance to Colistin in Wild-Type Klebsiella pneumoniae Isolates From Clinical Origin.
Microbiology Spectrum, 2023 Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to colistin. The aim of this work was to study heteroresistance in 10 wild-type Klebsiella pneumoniae isolates of clinical origin ...
Teresa García-Martínez +2 more
exaly +3 more sources
Vancomycin heteroresistance in Staphylococcus haemolyticus: elusive phenotype
Future Science OA, 2021 Aim: To determine the presence of vancomycin heteroresistance in Staphylococcus haemolyticus. Materials & methods: A total of 48 rifampicin-resistant S. haemolyticus isolates from bloodstream infections were included.
Shalini Anandan +5 more
core +4 more sources
The highly dynamic nature of bacterial heteroresistance impairs its clinical detection
Communications Biology, 2021 Bacterial populations can show heteroresistance, where an antibiotic resistant subpopulation is part of a susceptible one. Pereira et al. show in Escherichia coli and Salmonella enterica that disk diffusion, a common antibiotic susceptibility test ...
Cátia Pereira +4 more
doaj +2 more sources
Reaction Kinetic Models of Antibiotic Heteroresistance [PDF]
International Journal of Molecular Sciences, 2019 Bacterial heteroresistance (i.e., the co-existence of several subpopulations with different antibiotic susceptibilities) can delay the clearance of bacteria even with long antibiotic exposure.
Martinecz, Antal +7 more
core +5 more sources
Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease [PDF]
Frontiers in Microbiology, 2023 Antibiotic resistance is a major Public Health challenge worldwide. Mechanisms other than resistance are described as contributors to therapeutic failure.
Celia Gil-Campillo +15 more
doaj +2 more sources
Species-dependent in polymyxin B heteroresistance: genomic insights into adaptive evolution in Enterobacteriaceae [PDF]
Annals of Clinical Microbiology and AntimicrobialsBackground Polymyxin heteroresistance poses a growing challenge in antimicrobial resistance management, yet its epidemiological features and molecular basis across different bacterial species and environments remain poorly understood. This study aimed to
Hui Zhang +7 more
doaj +2 more sources
Tandem amplification of the umpA allele contributes to ceftazidime-avibactam heteroresistance in clinical carbapenem-resistant Klebsiella pneumoniae isolates [PDF]
Microbiology SpectrumCeftazidime-avibactam (CAZ/AVI, CZA) combination has shown promising efficacy against carbapenem-resistant Klebsiella pneumoniae (CRKP); however, several recent studies have reported resistance to CZA in CRKP.
Mengyao Wang +10 more
doaj +2 more sources
Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]
iScienceSummary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du +3 more
doaj +2 more sources
Impact of heteroresistance on treatment outcomes of people with drug-resistant TB [PDF]
IJTLD OpenBACKGROUND: Poor treatment outcomes among people with drug-resistant TB (DR-TB) are a major concern. Heteroresistance (presence of susceptible and resistant Mycobacterium tuberculosis in the same sample) has been identified in some people with TB, but ...
R. Crowder +29 more
doaj +2 more sources
mBioHeteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj +2 more sources