Results 21 to 30 of about 5,136 (212)
Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population [PDF]
, 2020 Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming.
Debski, Pawel R. +9 more
core +1 more source
Reaction Kinetic Models of Antibiotic Heteroresistance [PDF]
International Journal of Molecular Sciences, 2019 Bacterial heteroresistance (i.e., the co-existence of several subpopulations with different antibiotic susceptibilities) can delay the clearance of bacteria even with long antibiotic exposure. Some proposed mechanisms have been successfully described with mathematical models of drug-target binding where the mechanism’s downstream of drug-target binding
Antal Martinecz +3 more
openaire +3 more sources
Detection of Heteroresistant Mycobacterium tuberculosis by Pyrosequencing [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT The ability of pyrosequencing to detect a resistant minority population of a heteroresistant Mycobacterium tuberculosis strain was investigated by performing a titration study. A mutant signal was noted only when the proportion of mutant DNA in the DNA target was 35 to 50%, showing that the ...
Anna, Engström +2 more
openaire +2 more sources
Heteroresistance: a concern of increasing clinical significance? [PDF]
Clinical Microbiology and Infection, 2008 Recent studies have focused on issues related to heteroresistance, including its definition, methods of detection and frequency. Most such studies have reported data concerning infections caused by Staphylococcus aureus, but the clinical significance of heteroresistance is unclear. Six studies have described infections caused by S.
Falagas, M.E. +3 more
openaire +3 more sources
Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, 2021 Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs.
Jim Werngren +4 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundAntimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and ...
You-hua Wang +7 more
doaj +1 more source
Vancomycin Heteroresistance in Staphylococcus Haemolyticus : Elusive Phenotype
Future Science OA, 2021 To determine the presence of vancomycin heteroresistance in Staphylococcus haemolyticus.A total of 48 rifampicin-resistant S. haemolyticus isolates from bloodstream infections were included. Vancomycin heteroresistance was determined using the population analysis profile-area under curve (PAP-AUC) method. All the isolates were screened for the presence
Yamuna Devi Bathavatchalam +5 more
openaire +3 more sources
Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin
Microbiology Spectrum, 2023 Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to colistin. The aim of this work was to study heteroresistance in 10 wild-type Klebsiella pneumoniae isolates of clinical origin ...
Irene Sánchez-León +4 more
doaj +1 more source
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]
, 2018 BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J +13 more
core +6 more sources
Frontiers in Microbiology, 2023 Antibiotic resistance is a major Public Health challenge worldwide. Mechanisms other than resistance are described as contributors to therapeutic failure.
Celia Gil-Campillo +15 more
doaj +1 more source