Results 21 to 30 of about 3,808 (178)

An Investigation of Colistin Heteroresistance in <i>Klebsiella pneumoniae</i> Isolates in Iran. [PDF]

Biomed Res Int
Background According to the World Health Organization 2024 bacterial priority pathogens list, carbapenem‐resistant Enterobacterales (CRE) were listed among the critical priority pathogens. Heteroresistance (i.e., a bacterial isolate that appears susceptible but harbors resistant subpopulations) represents a challenge in traditional laboratory testing ...
Rad ZR, Rad ZR, Goudarzi H, Goudarzi M, Javidi M, Sharahi JY, Kargar M, Hashemi A.   +7 more
europepmc   +2 more sources

Two types of colistin heteroresistance in Acinetobacter baumannii isolates

Emerging Microbes and Infections, 2020
In this study, we investigated the colistin heteroresistance patterns in Acinetobacter baumannii isolates. To identify colistin heteroresistance, population analysis profiling was performed for six in vitro colistin-susceptible A.
Kwan Soo Ko, Hyunkeun Kim
exaly   +3 more sources

Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]

iScience
Summary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong   +3 more
doaj   +2 more sources

Evaluation of Xpert MTB/XDR and Deeplex Myc-TB for the Rapid Detection of Drug Resistance in <i>Mycobacterium tuberculosis</i>. [PDF]

Int J Microbiol
Objectives Rapid identification of drug‐resistant tuberculosis remains critical for the initiation of appropriate treatment regimens, improved success rates and reduction in the development of drug resistance. In this study, we compared the diagnostic performance of two novel diagnostic tests, Xpert MTB/XDR and Deeplex Myc‐TB (both CE marked).
Park M, Solanki P, McHugh TD, Kon OM, Satta G.   +4 more
europepmc   +2 more sources

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity [PDF]

Clinical Microbiology Reviews, 2015
SUMMARY “Heteroresistance” describes a phenomenon where subpopulations of seemingly isogenic bacteria exhibit a range of susceptibilities to a particular antibiotic. Unfortunately, a lack of standard methods to determine heteroresistance has led to inappropriate use of this term.
El-Halfawy, Omar M., Valvano, Miguel A.
openaire   +5 more sources

Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]

BMC Microbiology
Background Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong, Zhidong Hu, Ling Yang, Haifang Kong, Yuanhong Xu   +4 more
doaj   +2 more sources

Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli [PDF]

mBio
Heteroresistance is a transient resistance phenotype characterized by the presence of small subpopulations of bacterial cells with elevated antibiotic resistance within a susceptible main population.
Sheida Heidarian, Karin Hjort, Hervé Nicoloff, Dan I. Andersson   +3 more
doaj   +2 more sources

An investigation of gene dosage reveals that increased sensitivity to D-cycloserine divergently impacts the transience of heteroresistance in Escherichia coli [PDF]

mBio
Heteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj   +2 more sources

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study [PDF]

Emerging Microbes and Infections
Mixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes.
Yanping Liu, Yangyi Zhang, Xiaoyu Lu, Zheyuan Wu, Minjuan Li, Rui Zhang, Yixiao Lu, Renjie Hou, Yating Ji, Qingping Zhang, Qi Jiang, Jing Li, Yuan Jiang, Yunxia Wang, Jianhui Yuan, Howard E. Takiff, Xin Chen, Xin Shen, Chongguang Yang   +18 more
doaj   +2 more sources

Antibiotic Heteroresistance in Klebsiella pneumoniae

International Journal of Molecular Sciences, 2022
Klebsiella pneumoniae is one of the most common pathogens responsible for infections, including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence of multidrug-resistant K. pneumoniae was recognized in 2017 by the World Health Organization as a critical public health threat.
Karolina Wiktoria Stojowska-Swędrzyńska, Dorota Kuczynska-Wisnik, Adrianna Łupkowska   +2 more
exaly   +1 more source