Results 31 to 40 of about 3,968 (183)
Microbiology Spectrum, 2023 Colistin has been considered a last-line option for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Heterogeneous resistance to colistin leads to unexplained clinical colistin treatment failure for CRKP. Our study
Yuesong Weng +9 more
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Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]
BMC MicrobiologyBackground Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong +4 more
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Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates
Microbiology SpectrumHeteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier +2 more
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BMC Microbiology, 2018 Background Mortality rates for patients with Staphylococcus aureus (S. aureus) infections have improved only modestly in recent decades and S. aureus infections remain a major clinical challenge This study investigated the in vitro antimicrobial activity
Fan Zhang +12 more
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Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms
Xiehe Yixue ZazhiPolymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.
LI Yanbing, ZHOU Menglan, XU Yingchun
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Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance
npj Antimicrobials and ResistanceBacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases.
Linna Xu +5 more
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Heteroresistance to Colistin in Clinical Isolates of Klebsiella pneumoniae Producing OXA-48 [PDF]
Antibiotics, 2023 Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to this antibiotic. Colistin resistance in Gram-negative bacteria is more frequently related to chromosomal mutations and insertions.
Irene Sánchez-León +5 more
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Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates
BMC Infectious DiseasesBackground Antibiotic heteroresistance is a common phenotype observed in a variety of pathogenic bacteria such as K. pneumonia: A subpopulation of cells with a higher MIC than the dominant population is defined as heteroresistance.
Saeed Khoshnood +5 more
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Nature CommunicationsHeteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff +3 more
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Ceftaroline-Heteroresistant Staphylococcus aureus [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA).
Stephanie N, Saravolatz +4 more
openaire +2 more sources