Results 31 to 40 of about 3,479 (180)

Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates

BMC Infectious Diseases
Background Antibiotic heteroresistance is a common phenotype observed in a variety of pathogenic bacteria such as K. pneumonia: A subpopulation of cells with a higher MIC than the dominant population is defined as heteroresistance.
Saeed Khoshnood, Mohammad Hossein Haddadi, Nourkhoda Sadeghifard, Abbas Maleki, Ebrahim Kouhsari, Hassan Valadbeigi   +5 more
doaj   +2 more sources

Resolving colistin resistance and heteroresistance in Enterobacter species

Nature Communications, 2023
Taxonomical complexity has muddled the classification of clinically relevant Enterobacter species. Authors carry out a genome-based study on clinical isolates to investigate colistin resistance and heteroresistance in ...
Anna M. Rohde, Bajarang Vasant Kumbhar, Evelyn Kramme, Harald Seifert, Renate Frantz, Dominik Schwudke, Nicolas Gisch, Maria J. G. T. Vehreschild, Winfried V. Kern, Sarah V. Walker, Alexander Mischnik, Can Imirzalioglu, Silke Peter, Swapnil Prakash Doijad, Georg Alexander Häcker, Jane Falgenhauer, Jan Rupp, Evelina Tacconelli, Trinad Chakraborty, Janine Zweigner, Simone Eisenbeis, Hanna Gölz, DZIF R-Net Study Group, Petra Gastmeier, Axel Kola, Nadja Käding, Linda Falgenhauer, Michael Behnke, Michael Buhl   +28 more
core   +7 more sources

Fluconazole Resistance and Heteroresistance in Cryptococcus spp.: Mechanisms and Implications [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
The reference methodology for evaluating antifungal susceptibility is based on determining the minimum inhibitory concentration (MIC), which is the lowest drug concentration capable of inhibiting fungal growth.
Izabela de Mesquita Bárcia Moreira, Naira Sulany Oliveira de Sousa, Juan Diego Ribeiro de Almeida, Robert Langlady Lira Rosas Filho, Katia Santana Cruz, Ani Beatriz Jackisch Matsuura, Márcia de Souza Carvalho Melhem, Érica Simplício de Souza, Hagen Frickmann, Marcus Vinícius Guimarães Lacerda, João Vicente Braga de Souza   +10 more
doaj   +2 more sources

Investigation of voriconazole heteroresistance in clinical isolates of Trichosporon asahii from a multicenter study in China [PDF]

Microbiology Spectrum
Heteroresistance refers to the presence of subpopulations within seemingly homogeneous microbial cells that exhibit varying sensitivities to antifungal agents, potentially contributing to treatment failure.
Chenlu Liu, Qiaoying Gao, Yingxing Li, Jinhan Yu, Shuying Yu, Xinfei Chen, Xue Li, Yingchun Xu, Ying Zhao, Lina Guo   +9 more
doaj   +2 more sources

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms

Xiehe Yixue Zazhi
Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.
LI Yanbing, ZHOU Menglan, XU Yingchun
doaj   +2 more sources

Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance

npj Antimicrobials and Resistance
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases.
Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao   +5 more
doaj   +3 more sources

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +2 more sources

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K ...
Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen   +5 more
doaj   +2 more sources

Investigation of bedaquiline heteroresistance among Mycobacterium tuberculosis isolates from Pakistan

Microbiology Spectrum
Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid, Shaukat Iqbal, Sabira Tahseen, Yanlin Zhao   +3 more
doaj   +2 more sources

Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance

BMC Microbiology, 2018
Background Mortality rates for patients with Staphylococcus aureus (S. aureus) infections have improved only modestly in recent decades and S. aureus infections remain a major clinical challenge This study investigated the in vitro antimicrobial activity
Fan Zhang, Bing Bai, Guang-jian Xu, Zhi-wei Lin, Gui-qiu Li, Zhong Chen, Hang Cheng, Xiang Sun, Hong-yan Wang, Yan-wei Chen, Jin-xin Zheng, Qi-wen Deng, Zhi-jian Yu   +12 more
doaj   +2 more sources