Results 31 to 40 of about 3,808 (178)

Multicenter Study of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Strains in China

Microbiology Spectrum, 2023
Colistin has been considered a last-line option for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Heterogeneous resistance to colistin leads to unexplained clinical colistin treatment failure for CRKP. Our study
Yuesong Weng, Tao Wang, Bin Huang, Hua Yu, Wei Jia, Bin Shan, Fen Qu, Yiwei Tang, Liang Chen, Hong Du   +9 more
doaj   +2 more sources

Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression [PDF]

BMC Microbiology
Background Salmonella enterica Serovar Typhimurium (S. Typhimurium) is a major global foodborne pathogen. In our previous study, the S. Typhimurium ATCC 14028 strain harboring plasmid pHXY0908 survived at fourfold its ciprofloxacin MIC (MIC0908 = 0.125 ...
Mengyuan Li, Xiaoyin Feng, Qianting Jian, Mou Jing, Xiran Wang, Zehua Cui, Rongmin Zhang, Jian Sun, Yahong Liu, Xiaoping Liao, Xinlei Lian   +10 more
doaj   +2 more sources

Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates

BMC Infectious Diseases
Background Antibiotic heteroresistance is a common phenotype observed in a variety of pathogenic bacteria such as K. pneumonia: A subpopulation of cells with a higher MIC than the dominant population is defined as heteroresistance.
Saeed Khoshnood, Mohammad Hossein Haddadi, Nourkhoda Sadeghifard, Abbas Maleki, Ebrahim Kouhsari, Hassan Valadbeigi   +5 more
doaj   +2 more sources

Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance

npj Antimicrobials and Resistance
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases.
Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao   +5 more
doaj   +3 more sources

Heteroresistance to Colistin in Clinical Isolates of Klebsiella pneumoniae Producing OXA-48 [PDF]

Antibiotics, 2023
Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to this antibiotic. Colistin resistance in Gram-negative bacteria is more frequently related to chromosomal mutations and insertions.
Irene Sánchez-León, Teresa García-Martínez, Seydina M. Diene, Elena Pérez-Nadales, Luis Martínez-Martínez, Jean-Marc Rolain   +5 more
doaj   +2 more sources

Impact of heteroresistance on treatment outcomes of people with drug-resistant TB [PDF]

IJTLD Open
BACKGROUND: Poor treatment outcomes among people with drug-resistant TB (DR-TB) are a major concern. Heteroresistance (presence of susceptible and resistant Mycobacterium tuberculosis in the same sample) has been identified in some people with TB, but ...
R. Crowder, M. Kato-Maeda, B. Schwem, A. dela Tonga, D.M. Geocaniga-Gaviola, E. Lopez, C.L. Valdez, A.R. Lim, N. Hunat, A.G. Sedusta, C.A. Sacopon, G.A.M. Atienza, E. Bulag, D. Lim, J. Bascuña, K. Shah, R.P. Basillio, C.A. Berger, M.C.D.P. Lopez, S. Sen, C. Allender, M. Folkerts, U. Karaoz, E. Brodie, S. Mitarai, A.M.C. Garfin, M.C. Ama, D.M. Engelthaler, A. Cattamanchi, R. Destura   +29 more
doaj   +2 more sources

Epidemiology of cryptococcal meningitis and fluconazole heteroresistance in Cryptococcus neoformans isolates from a teaching hospital in southwestern China

Microbiology Spectrum
Cryptococcal meningitis (CM), a common and serious opportunistic infection mostly caused by Cryptococcus neoformans, is primarily treated with fluconazole.
Yunfei Huang, Yongqi Zhang, Shuangshuang Yang, Hongling Lu, Hanbing Yu, Xingyue Wang, Xiaojiong Jia, Dijiao Tang, Linhong Wu, Shifeng Huang, Ping Yang   +10 more
doaj   +2 more sources

Fluconazole Resistance and Heteroresistance in Cryptococcus spp.: Mechanisms and Implications [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
The reference methodology for evaluating antifungal susceptibility is based on determining the minimum inhibitory concentration (MIC), which is the lowest drug concentration capable of inhibiting fungal growth.
Izabela de Mesquita Bárcia Moreira, Naira Sulany Oliveira de Sousa, Juan Diego Ribeiro de Almeida, Robert Langlady Lira Rosas Filho, Katia Santana Cruz, Ani Beatriz Jackisch Matsuura, Márcia de Souza Carvalho Melhem, Érica Simplício de Souza, Hagen Frickmann, Marcus Vinícius Guimarães Lacerda, João Vicente Braga de Souza   +10 more
doaj   +3 more sources

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms

Xiehe Yixue Zazhi
Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.
LI Yanbing, ZHOU Menglan, XU Yingchun
doaj   +2 more sources

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +2 more sources