Results 51 to 60 of about 3,968 (183)

Heteroresistance to Fosfomycin Is Predominant in Streptococcus pneumoniae and Depends on the murA1 Gene

, 2013
Fosfomycin targets the first step of peptidoglycan biosynthesis in Streptococcus pneumoniae catalyzed by UDP-N-acetylglucosamine enolpyruvyltransferase (MurA1). We investigated whether heteroresistance to fosfomycin occurs in S. pneumoniae. We found that
Hilty, Markus, Martínez-Ripoll, Martín, Hermoso, Juan A, Hathaway, Lucy Jane, Gutiérrez-Fernández, Javier, Engel, Hansjürg, Flückiger, Christine, Mühlemann, Kathrin, Mühlemann, Kathrin (author), Hilty M, Hathaway, Lucy J., Hermoso, Juan A. (author), Martínez-Ripoll, Martín (author), Engel H, Flückiger C, Martínez-Ripoll M, Gutiérrez-Fernández, Javier (author), Engel, Hansjürg (author), Hermoso JA, Hermoso, Juan A., Flückiger, Christine (author), Hilty, Markus (author), Gutiérrez Fernández, Javier, Mühlemann K, Gutiérrez-Fernández J, Hathaway, Lucy J. (author), Hathaway LJ   +26 more
core   +2 more sources

Bacteremia Caused by Staphylococci with Inducible Vancomycin Heteroresistance [PDF]

Clinical Infectious Diseases, 1999
The clinical significance of bacteremia due to vancomycin-heteroresistant staphylococci and a rapid laboratory screening method were examined; 203 strains of staphylococci isolated from patients with clinically significant bacteremia were screened by the disk-agar method with use of vancomycin-salt agar to demonstrate satellitism around an aztreonam ...
Wong, SSY, Woo, PCY, Yuen, KY, Ho, PL
openaire   +3 more sources

Mechanism of Eravacycline Resistance in Clinical Enterococcus faecalis Isolates From China

Frontiers in Microbiology, 2020
Opportunistic infections caused by multidrug-resistant Enterococcus faecalis strains are a significant clinical challenge. Eravacycline (Erava) is a synthetic fluorocycline structurally similar to tigecycline (Tige) that exhibits robust antimicrobial ...
Zewen Wen, Zewen Wen, Yongpeng Shang, Yongpeng Shang, Guangjian Xu, Zhangya Pu, Zhiwei Lin, Zhiwei Lin, Bing Bai, Zhong Chen, Jinxin Zheng, Qiwen Deng, Zhijian Yu, Zhijian Yu   +13 more
doaj   +1 more source

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study

Emerging Microbes and Infections
Mixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes.
Yanping Liu, Yangyi Zhang, Xiaoyu Lu, Zheyuan Wu, Minjuan Li, Rui Zhang, Yixiao Lu, Renjie Hou, Yating Ji, Qingping Zhang, Qi Jiang, Jing Li, Yuan Jiang, Yunxia Wang, Jianhui Yuan, Howard E. Takiff, Xin Chen, Xin Shen, Chongguang Yang   +18 more
doaj   +1 more source

Heteroresistance Is Associated With in vitro Regrowth During Colistin Treatment in Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Microbiology, 2022
Polymyxins including polymyxin B and colistin (polymyxin E) are considered the last resort for treating infections caused by carbapenem-resistant gram-negative bacteria.
Yifan Wang, Xinqian Ma, Lili Zhao, Yukun He, Wenyi Yu, Shining Fu, Wentao Ni, Zhancheng Gao   +7 more
doaj   +1 more source

Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant Enterobacterales in the United States

, 2021
Heteroresistance is a form of antibiotic resistance where a bacterial strain is comprised of a minor resistant subpopulation and a majority susceptible subpopulation. We showed previously that colistin heteroresistance can mediate the failure of colistin
Victor I. Band, Erin C. Phipps, I. King Jordan, Chris Bower, Matthew Sorensen, Robert K. Ernst, Rebecca Pierce, Lucy E. Wilson, David A. Hufnagel, Suzanne E. Dale, Lavanya Rishishwar, Sarah W. Satola, Monica M. Farley, Erik Nilsson, Roberto L. Vargas, Eileen M. Burd, David S. Weiss, Ghinwa Dumyati, Jesse T. Jacob, Andrew B. Conley, Marion A. Kainer, Richard D. Smith, Dwight J. Hardy   +22 more
core   +1 more source

Susceptibility‐Guided Triple Therapy Achieves High Helicobacter pylori Eradication Regardless of Duration

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Although clarithromycin resistance is a major cause of empirical triple therapy failure for Helicobacter pylori eradication, the clinical relevance of amoxicillin susceptibility remains uncertain. We first compared eradication outcomes between empirical and susceptibility‐guided tailored triple therapy and then evaluated the
Hoyoung Wang, Ji Yong Ahn, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon‐Yong Jung, Jung Mogg Kim   +10 more
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Summary of parameters used in the mathematical models of persistence and heteroresistance.

, 2023
Summary of parameters used in the mathematical models of persistence and heteroresistance.
Rodney Dawson (101812), Antal Martinecz (5819777), Colin Hemez (15286135), Andreas H. Diacon (10853076), Martin J. Boeree (14786362), Pia Abel zur Wiesch (7208468), Rob E. Aarnoutse (3394559)   +6 more
core   +1 more source

Heteroresistance to Meropenem in Carbapenem-Susceptible Acinetobacter baumannii [PDF]

Journal of Clinical Microbiology, 2009
ABSTRACT The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. The MICs for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing (ST).
Ikonomidis, A., Neou, E., Gogou, V., Vrioni, G., Tsakris, A., Pournaras, S.   +5 more
openaire   +3 more sources