Results 51 to 60 of about 2,895 (162)

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

Photochemistry and Photobiology, Volume 102, Issue 4, Page 924-933, July/August 2026.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira, Bruna Carolina Corrêa, Vanderlei Salvador Bagnato, Kate Cristina Blanco   +3 more
wiley   +1 more source

Resolving colistin resistance and heteroresistance in Enterobacter species

Nature Communications, 2022
Abstract Enterobacter cloacae complex (ECC) represent globally important nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter xiangfangensis as the most common species (65.5%) detected, a result replicated by examining a global pool of 3246 isolates.
Doijad, Swapnil Prakash, Gisch, Nicolas, Frantz, Renate, Kumbhar, Bajarang Vasant, Falgenhauer, Jane, Imirzalioglu, Can, Falgenhauer, Linda, Mischnik, Alexander, Rupp, Jan, Behnke, Michael, Buhl, Michael, Eisenbeis, Simone, Gastmeier, Petra, Gölz, Hanna, Häcker, Georg Alexander, Käding, Nadja, Kern, Winfried V., Kola, Axel, Kramme, Evelyn, Peter, Silke, Rohde, Anna M., Seifert, Harald, Tacconelli, Evelina, Vehreschild, Maria J. G. T., Walker, Sarah V., Zweigner, Janine, Schwudke, Dominik, Diaz, L. A. Peña, Pilarski, G., Thoma, N., Weber, A., Vavra, M., Schuster, S., Peyerl-Hoffmann, G., Hamprecht, A., Proske, S., Stelzer, Y., Wille, J., Lenke, D., Bader, B., Dinkelacker, A., Hölzl, F., Kunstle, L., Chakraborty, Trinad, Justus Liebig University Giessen   +44 more
openaire   +6 more sources

Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in Enterobacter cloacae complex

Frontiers in Cellular and Infection Microbiology
IntroductionColistin has emerged as the last resort for treating multidrug-resistant Enterobacter cloacae complex (ECC) infections. The primary purposes of this study were to demonstrate the presence of colistin heteroresistance in ECC and to further ...
Chunli Wei, Jiming Wu, Jisheng Zhang, Youtao Liang, Kaixin Yu, Kaixin Yu, Mingjing Liao, Xushan Liang, Jianmin Wang, Wenzhang Long, Jin Wang, Shijian Chen, Yang Yang, Xue Gong, Jie Li, Xiaoli Zhang   +15 more
doaj   +1 more source

Phenotypic Detection of Hemin-Inducible Trimethoprim-Sulfamethoxazole Heteroresistance in Staphylococcus aureus

Microbiology Spectrum, 2021
Trimethoprim-sulfamethoxazole (SXT) is a valuable second-line antimicrobial agent to treat methicillin-resistant Staphylococcus aureus infections. Discrepancies between various antibiotic susceptibility testing (AST) methods for SXT susceptibility in S ...
Dennis Nurjadi, Quan Chanthalangsy, Elfi Zizmann, Vanessa Stuermer, Maximilian Moll, Sabrina Klein, Sébastien Boutin, Klaus Heeg, Philipp Zanger   +8 more
doaj   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Mechanisms of Heteroresistance and Resistance to Imipenem in Pseudomonas aeruginosa.

Infection and drug resistance, 2020
Heteroresistance is a phenomenon that occurs in all bacteria and can cause treatment failure. Yet, the exact mechanisms responsible for heteroresistance still remain unknown. The following study investigated the mechanisms of imipenem-heteroresistance and -resistance in Pseudomonas aeruginosa clinical isolates from Wenzhou, China.Imipenem resistance ...
Xu,Ye, Zheng,Xiangkuo, Zeng,Weiliang, Chen,Tao, Liao,Wenli, Qian,Jiao, Lin,Jie, Zhou,Cui, Tian,Xuebin, Cao,Jianming, Zhou,Tieli   +10 more
openaire   +4 more sources

Heteroresistance to Meropenem in Carbapenem-Susceptible Acinetobacter baumannii [PDF]

Journal of Clinical Microbiology, 2009
ABSTRACT The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. The MICs for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing (ST).
Ikonomidis, A., Neou, E., Gogou, V., Vrioni, G., Tsakris, A., Pournaras, S.   +5 more
openaire   +3 more sources

Using Selective Agar Containing Ciprofloxacin and Tetracycline Reveals Resistant Oral Microbiota in Healthy and Periodontitis Patients

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Oral biofilms from healthy and periodontitis patients harbor diverse bacteria, including aerobes and obligate anaerobes. Using selective media with tetracycline or ciprofloxacin, 495 strains (106 species) were isolated. Resistance was common—32.9% to ciprofloxacin, 15.2% to tetracycline, 0.6% to ampicillin—highlighting the oral cavity as a reservoir ...
Marietta Wolf, Jennifer Metz, Annette Wittmer, Klaus Pelz, Kirstin Vach, Christiane von Ohle, Diana Wolff, Cornelia Frese, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke, Lerato Hlekelele, Charles Maphanga, Mabotse Tjale, Felix S. Dube, Saturnin Ombinda‐Lemboumba, Patience Mthunzi‐Kufa   +6 more
wiley   +1 more source

Epidemiology of cryptococcal meningitis and fluconazole heteroresistance in Cryptococcus neoformans isolates from a teaching hospital in southwestern China

Microbiology Spectrum
Cryptococcal meningitis (CM), a common and serious opportunistic infection mostly caused by Cryptococcus neoformans, is primarily treated with fluconazole.
Yunfei Huang, Yongqi Zhang, Shuangshuang Yang, Hongling Lu, Hanbing Yu, Xingyue Wang, Xiaojiong Jia, Dijiao Tang, Linhong Wu, Shifeng Huang, Ping Yang   +10 more
doaj   +1 more source