Results 61 to 70 of about 3,479 (180)

The highly dynamic nature of bacterial heteroresistance impairs its clinical detection

Communications Biology, 2021
Bacterial populations can show heteroresistance, where an antibiotic resistant subpopulation is part of a susceptible one. Pereira et al. show in Escherichia coli and Salmonella enterica that disk diffusion, a common antibiotic susceptibility test ...
Cátia Pereira, Jimmy Larsson, Karin Hjort, Johan Elf, Dan I. Andersson   +4 more
doaj   +1 more source

Phenotypic Detection of Hemin-Inducible Trimethoprim-Sulfamethoxazole Heteroresistance in Staphylococcus aureus

Microbiology Spectrum, 2021
Trimethoprim-sulfamethoxazole (SXT) is a valuable second-line antimicrobial agent to treat methicillin-resistant Staphylococcus aureus infections. Discrepancies between various antibiotic susceptibility testing (AST) methods for SXT susceptibility in S ...
Dennis Nurjadi, Quan Chanthalangsy, Elfi Zizmann, Vanessa Stuermer, Maximilian Moll, Sabrina Klein, Sébastien Boutin, Klaus Heeg, Philipp Zanger   +8 more
doaj   +1 more source

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

Photochemistry and Photobiology, EarlyView.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira, Bruna Carolina Corrêa, Vanderlei Salvador Bagnato, Kate Cristina Blanco   +3 more
wiley   +1 more source

What is the clinical significance of 'heteroresistance' in nonfermenting Gram-negative strains?

, 2023
Purpose of review: The aim of this study was to discuss the potential clinical significance of heteroresistance in nonfermenting Gram-negative bacilli (GNB).
Tiseo, Giusy, Galfo, Valentina, Falcone, Marco   +2 more
core   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology
Ceftazidime–avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA
Yitan Li, Xiandi Chen, Yingyi Guo, Yingzhuo Lin, Xiaohu Wang, Guohua He, Mingzhen Wang, Jianbo Xu, Mingdong Song, Xixi Tan, Chao Zhuo, Zhiwei Lin   +11 more
doaj   +1 more source

Using Selective Agar Containing Ciprofloxacin and Tetracycline Reveals Resistant Oral Microbiota in Healthy and Periodontitis Patients

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Oral biofilms from healthy and periodontitis patients harbor diverse bacteria, including aerobes and obligate anaerobes. Using selective media with tetracycline or ciprofloxacin, 495 strains (106 species) were isolated. Resistance was common—32.9% to ciprofloxacin, 15.2% to tetracycline, 0.6% to ampicillin—highlighting the oral cavity as a reservoir ...
Marietta Wolf, Jennifer Metz, Annette Wittmer, Klaus Pelz, Kirstin Vach, Christiane von Ohle, Diana Wolff, Cornelia Frese, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant Enterobacterales in the United States

, 2021
Heteroresistance is a form of antibiotic resistance where a bacterial strain is comprised of a minor resistant subpopulation and a majority susceptible subpopulation. We showed previously that colistin heteroresistance can mediate the failure of colistin
Wilson, Lucy E, Victor I. Band, Sorensen, Matthew, Dumyati, Ghinwa, Erin C. Phipps, I. King Jordan, Smith, Richard D, Chris Bower, Phipps, Erin C, Matthew Sorensen, Robert K. Ernst, Conley, Andrew B, Rishishwar, Lavanya, Rebecca Pierce, Pierce, Rebecca, Nilsson, Erik, Band, Victor I, Lucy E. Wilson, Kainer, Marion A, Farley, Monica M, Ernst, Robert K, Bower, Chris, David A. Hufnagel, Suzanne E. Dale, Lavanya Rishishwar, Hardy, Dwight J, Sarah W. Satola, Jordan, I King, Monica M. Farley, Erik Nilsson, Vargas, Roberto L, Roberto L. Vargas, Dale, Suzanne E, Eileen M. Burd, David S. Weiss, Burd, Eileen M, Ghinwa Dumyati, Jesse T. Jacob, Weiss, David S, Satola, Sarah W, Andrew B. Conley, Hufnagel, David A, Marion A. Kainer, Richard D. Smith, Jacob, Jesse T, Dwight J. Hardy   +45 more
core   +1 more source

Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke, Lerato Hlekelele, Charles Maphanga, Mabotse Tjale, Felix S. Dube, Saturnin Ombinda‐Lemboumba, Patience Mthunzi‐Kufa   +6 more
wiley   +1 more source

Mechanisms of Heteroresistance and Resistance to Imipenem in Pseudomonas aeruginosa.

Infection and drug resistance, 2020
Heteroresistance is a phenomenon that occurs in all bacteria and can cause treatment failure. Yet, the exact mechanisms responsible for heteroresistance still remain unknown. The following study investigated the mechanisms of imipenem-heteroresistance and -resistance in Pseudomonas aeruginosa clinical isolates from Wenzhou, China.Imipenem resistance ...
Xu,Ye, Zheng,Xiangkuo, Zeng,Weiliang, Chen,Tao, Liao,Wenli, Qian,Jiao, Lin,Jie, Zhou,Cui, Tian,Xuebin, Cao,Jianming, Zhou,Tieli   +10 more
openaire   +4 more sources