Results 61 to 70 of about 3,968 (183)

Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology
Ceftazidime–avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA
Yitan Li, Xiandi Chen, Yingyi Guo, Yingzhuo Lin, Xiaohu Wang, Guohua He, Mingzhen Wang, Jianbo Xu, Mingdong Song, Xixi Tan, Chao Zhuo, Zhiwei Lin   +11 more
doaj   +1 more source

Programmable 3D Microfluidics Reveals Motility‐Driven Antibiotic Resistance Evolution in Gradients

Small, Volume 22, Issue 59, 22 October 2026.
Using a programmable microfluidic platform, this study shows that bacterial motility is crucial for resistance development in heterogeneous antibiotic landscapes. Motile Escherichia coli randomly migrates along antibiotic gradients, and sufficient movement is required for resistance to emerge.
Xiaobo Li, Jianan Yin, Yanqing Song, Andrew Glidle, William Sloan, He Huang, Maggie Cusack, Cindy J. Smith, Huabing Yin   +8 more
wiley   +1 more source

Glycopeptide Heteroresistance Among Coagulase-Negative Staphylococci: A Systematic Review and Meta-analysis [PDF]

We identified a high prevalence of glycopeptide heteroresistance amongst coagulase-negative staphylococci (41.4%, 95% confidence interval 30.7–52.9; meta-analysis including n = 1432 isolates).
Russell, Clark D, Wootton, Mandy, Gadsby, Naomi J, Dewar, Simon, Russell, Clark D; id_orcid, Olson, Ewan S, Ke, Min   +6 more
core   +1 more source

Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in Enterobacter cloacae complex

Frontiers in Cellular and Infection Microbiology
IntroductionColistin has emerged as the last resort for treating multidrug-resistant Enterobacter cloacae complex (ECC) infections. The primary purposes of this study were to demonstrate the presence of colistin heteroresistance in ECC and to further ...
Chunli Wei, Jiming Wu, Jisheng Zhang, Youtao Liang, Kaixin Yu, Kaixin Yu, Mingjing Liao, Xushan Liang, Jianmin Wang, Wenzhang Long, Jin Wang, Shijian Chen, Yang Yang, Xue Gong, Jie Li, Xiaoli Zhang   +15 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Mechanisms of Heteroresistance and Resistance to Imipenem in Pseudomonas aeruginosa.

Infection and drug resistance, 2020
Heteroresistance is a phenomenon that occurs in all bacteria and can cause treatment failure. Yet, the exact mechanisms responsible for heteroresistance still remain unknown. The following study investigated the mechanisms of imipenem-heteroresistance and -resistance in Pseudomonas aeruginosa clinical isolates from Wenzhou, China.Imipenem resistance ...
Xu,Ye, Zheng,Xiangkuo, Zeng,Weiliang, Chen,Tao, Liao,Wenli, Qian,Jiao, Lin,Jie, Zhou,Cui, Tian,Xuebin, Cao,Jianming, Zhou,Tieli   +10 more
openaire   +4 more sources

Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae [PDF]

Journal of Antimicrobial Chemotherapy, 2011
Sir, Klebsiella pneumoniae is an important pathogen that causes severe and life-threatening infections. Most isolates demonstrate resistance to various antimicrobial agents. Carbapenems have been widely used to treat serious infections with multidrug-resistant K. pneumoniae.
Georgios, Meletis, Egki, Tzampaz, Effrosyni, Sianou, Ioannis, Tzavaras, Danai, Sofianou   +4 more
openaire   +2 more sources

Resolving colistin resistance and heteroresistance in Enterobacter species

Nature Communications, 2022
Abstract Enterobacter cloacae complex (ECC) represent globally important nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter xiangfangensis as the most common species (65.5%) detected, a result replicated by examining a global pool of 3246 isolates.
Doijad, Swapnil Prakash, Gisch, Nicolas, Frantz, Renate, Kumbhar, Bajarang Vasant, Falgenhauer, Jane, Imirzalioglu, Can, Falgenhauer, Linda, Mischnik, Alexander, Rupp, Jan, Behnke, Michael, Buhl, Michael, Eisenbeis, Simone, Gastmeier, Petra, Gölz, Hanna, Häcker, Georg Alexander, Käding, Nadja, Kern, Winfried V., Kola, Axel, Kramme, Evelyn, Peter, Silke, Rohde, Anna M., Seifert, Harald, Tacconelli, Evelina, Vehreschild, Maria J. G. T., Walker, Sarah V., Zweigner, Janine, Schwudke, Dominik, Diaz, L. A. Peña, Pilarski, G., Thoma, N., Weber, A., Vavra, M., Schuster, S., Peyerl-Hoffmann, G., Hamprecht, A., Proske, S., Stelzer, Y., Wille, J., Lenke, D., Bader, B., Dinkelacker, A., Hölzl, F., Kunstle, L., Chakraborty, Trinad, Justus Liebig University Giessen   +44 more
openaire   +6 more sources

Current Helicobacter pylori Diagnostics: Established Methods, Resistance Testing, and Emerging Approaches

JGH Open, Volume 10, Issue 9, September 2026.
ABSTRACT Aims Accurate diagnosis of Helicobacter pylori infection is required to detect active infection, confirm eradication, assess gastric pathology when indicated, and obtain antimicrobial resistance information that may guide treatment. This review evaluates the clinical roles, limitations, and implementation maturity of established, molecular ...
Tianhua Tang, Erwin A. Paz, Kan Yu, Khui Hung Lee, Chin Yen Tay, Jingjing Wang, Barry James Marshall, Linli Hu, Wanting Fu, Ziyao Yang   +9 more
wiley   +1 more source

Prevalence of colistin heteroresistance in carbapenem-resistant Pseudomonas aeruginosa and association with clinical outcomes in patients: an observational study

, 2021
OBJECTIVES: To describe the prevalence of colistin heteroresistance in carbapenem-resistant Pseudomonas aeruginosa (CRPA) and evaluate the association with clinical outcomes.
Jacob, Jesse T.,, Andersson, Dan I, Davis, Michelle, Smith, Gillian, Page, Alexander M, Page, Alexander M.,, Weiss, David S.,, Howard-Anderson, Jessica,, Davis, Michelle,, Andersson, Dan I.,, Howard-Anderson, Jessica, Weiss, David S, Satola, Sarah W.,, Bower, Chris W, Satola, Sarah W, Bower, Chris W.,, Smith, Gillian,, Jacob, Jesse T   +17 more
core   +1 more source