Results 61 to 70 of about 5,136 (212)

Heteroresistance to Cephalosporins and Penicillins in Acinetobacter baumannii [PDF]

Journal of Clinical Microbiology, 2012
ABSTRACT Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii , a major pathogen causing nosocomial infections. Two A. baumannii
Kuei-Hsiang, Hung, Ming-Cheng, Wang, Ay-Huey, Huang, Jing-Jou, Yan, Jiunn-Jong, Wu   +4 more
openaire   +2 more sources

Heteroresistance to Colistin in Clinical Isolates of Klebsiella pneumoniae Producing OXA-48

Antibiotics, 2023
Heteroresistance to colistin can be defined as the presence of resistant subpopulations in an isolate that is susceptible to this antibiotic. Colistin resistance in Gram-negative bacteria is more frequently related to chromosomal mutations and insertions.
Irene Sánchez-León, Teresa García-Martínez, Seydina M. Diene, Elena Pérez-Nadales, Luis Martínez-Martínez, Jean-Marc Rolain   +5 more
doaj   +1 more source

Heteroresistance to Meropenem in Carbapenem-Susceptible Acinetobacter baumannii [PDF]

Journal of Clinical Microbiology, 2009
ABSTRACT The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. The MICs for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing (ST).
Ikonomidis, A., Neou, E., Gogou, V., Vrioni, G., Tsakris, A., Pournaras, S.   +5 more
openaire   +3 more sources

Phenotypic Detection of Hemin-Inducible Trimethoprim-Sulfamethoxazole Heteroresistance in Staphylococcus aureus

Microbiology Spectrum, 2021
Trimethoprim-sulfamethoxazole (SXT) is a valuable second-line antimicrobial agent to treat methicillin-resistant Staphylococcus aureus infections. Discrepancies between various antibiotic susceptibility testing (AST) methods for SXT susceptibility in S ...
Dennis Nurjadi, Quan Chanthalangsy, Elfi Zizmann, Vanessa Stuermer, Maximilian Moll, Sabrina Klein, Sébastien Boutin, Klaus Heeg, Philipp Zanger   +8 more
doaj   +1 more source

Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance

Journal of Fungi
Antifungal resistance poses a critical global health threat, particularly in immuno-compromised patients. Beyond the traditional resistance mechanisms rooted in heritable and stable mutations, a distinct phenomenon known as heteroresistance has been ...
Yanyu Su, Yi Li, Qiaolian Yi, Yingchun Xu, Tianshu Sun, Yingxing Li   +5 more
doaj   +1 more source

Gaining insights from Candida biofilm heterogeneity: one size does not fit all [PDF]

, 2018
Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic ...
Delaney, Christopher, Kean, Ryan, McLean, William, Metcalfe, Rebecca, Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Thomas, Rachael, Williams, Craig   +8 more
core   +4 more sources

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Using Selective Agar Containing Ciprofloxacin and Tetracycline Reveals Resistant Oral Microbiota in Healthy and Periodontitis Patients

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Oral biofilms from healthy and periodontitis patients harbor diverse bacteria, including aerobes and obligate anaerobes. Using selective media with tetracycline or ciprofloxacin, 495 strains (106 species) were isolated. Resistance was common—32.9% to ciprofloxacin, 15.2% to tetracycline, 0.6% to ampicillin—highlighting the oral cavity as a reservoir ...
Marietta Wolf, Jennifer Metz, Annette Wittmer, Klaus Pelz, Kirstin Vach, Christiane von Ohle, Diana Wolff, Cornelia Frese, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology
Ceftazidime–avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA
Yitan Li, Xiandi Chen, Yingyi Guo, Yingzhuo Lin, Xiaohu Wang, Guohua He, Mingzhen Wang, Jianbo Xu, Mingdong Song, Xixi Tan, Chao Zhuo, Zhiwei Lin   +11 more
doaj   +1 more source

Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke, Lerato Hlekelele, Charles Maphanga, Mabotse Tjale, Felix S. Dube, Saturnin Ombinda‐Lemboumba, Patience Mthunzi‐Kufa   +6 more
wiley   +1 more source