Results 81 to 90 of about 2,895 (162)

Fluconazole Resistance and Heteroresistance in Cryptococcus spp.: Mechanisms and Implications [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
The reference methodology for evaluating antifungal susceptibility is based on determining the minimum inhibitory concentration (MIC), which is the lowest drug concentration capable of inhibiting fungal growth.
Izabela de Mesquita Bárcia Moreira, Naira Sulany Oliveira de Sousa, Juan Diego Ribeiro de Almeida, Robert Langlady Lira Rosas Filho, Katia Santana Cruz, Ani Beatriz Jackisch Matsuura, Márcia de Souza Carvalho Melhem, Érica Simplício de Souza, Hagen Frickmann, Marcus Vinícius Guimarães Lacerda, João Vicente Braga de Souza   +10 more
doaj   +1 more source

Revisiting the Metallo‐β‐Lactamase–Mediated Antibiotic Resistance: Exploring Novel Mechanisms and Therapeutic Strategies

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
β‐Lactam resistance is one of the major health concerns today, primarily due to enzymes called β‐lactamases. Metallo‐β‐lactamases (MβLs) can cleave a wide range of β‐lactam antibiotics, including carbapenems. These enzymes require zinc (Zn) ions to function and can be inhibited by conventional β‐lactamase inhibitors.
Jahanvi Saini, Silvi Gautam, Divakar Sharma, Ankit Khanduri, Divya Venugopal, Guilherme Dilarri   +5 more
wiley   +1 more source

Global trends and research profile of antibiotic heteroresistance: a bibliometric and visual analysis

Frontiers in Microbiology
IntroductionAntibiotic heteroresistance challenges clinical treatment, risking adverse outcomes and antimicrobial resistance emergence. This study aims to explore its research status and trends.MethodsWe screened global publications on antibiotic ...
Jie Hou, Jie Hou, Jie Hou, Jie Hou, Chen Peng, Weilin Chen, Liang Peng, Liang Peng, Liang Peng, Ying Ma, Ying Ma, Ying Ma, Mei Kang, Mei Kang, Mei Kang   +14 more
doaj   +1 more source

Characterization of fosfomycin heteroresistance among multidrug-resistant Escherichia coli isolates from hospitalized patients in Rio de Janeiro, Brazil

Journal of Global Antimicrobial Resistance, 2020
Objectives: Urinary tract infections (UTIs) caused by multidrug-resistant Escherichia coli have become a major medical concern. Old antibiotics such as fosfomycin have become an alternative therapeutic option due to their effectiveness and, as a result ...
Ana Carolina da C. Campos, Nathália L. Andrade, Natacha Couto, Nico T. Mutters, Marjon de Vos, Ana Cláudia de P. Rosa, Paulo V. Damasco, Jerome R. Lo Ten Foe, Alex W. Friedrich, Monika A. Chlebowicz-Flissikowska, John W.A. Rossen   +10 more
doaj   +1 more source

In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain Amino Acid Transport System II Carrier Protein, Na/Pi Cotransporter Family Protein, and Fibronectin-Binding Protein

Frontiers in Microbiology, 2019
Omadacycline (Omad), a new tetracycline (Tet)-class broad-spectrum aminomethylcycline, has been reported to exhibit excellent potency against Gram-positive bacteria, including Staphylococcus aureus and Enterococci.
Bing Bai, Bing Bai, Zhiwei Lin, Zhiwei Lin, Zhangya Pu, Guangjian Xu, Guangjian Xu, Fan Zhang, Fan Zhang, Zhong Chen, Zhong Chen, Xiang Sun, Jinxin Zheng, Peiyu Li, Peiyu Li, Qiwen Deng, Qiwen Deng, Zhijian Yu, Zhijian Yu   +18 more
doaj   +1 more source

Biofilm Formation and the Pore Proteins ompF and ompC Lead to Heteroresistance in Escherichia coli

Antibiotics
Escherichia coli (E. coli) is a major pathogen responsible for mastitis and calf diarrhea in dairy cows and has developed heteroresistance (HR) to a wide range of antibiotics.
Jiaojiao Gao, Yating Wu, Xianlan Ma, Xiaowei Xu, Zhijie Zhang, Wei Shao, Nan Zheng, Tongjun Guo, Yankun Zhao   +8 more
doaj   +1 more source

Clinical impact of bacterial heteroresistance

JAC-Antimicrobial Resistance
Abstract Bacterial heteroresistance is defined when a seemingly susceptible population of bacteria contains one or more resistant subpopulations. This behaviour has been seen in a variety of bacteria and with many different antibiotics.
Callum Joyce, Saba Anwar, Charlotte Hind, J Mark Sutton, Chrysi Sergaki   +4 more
openaire   +1 more source

Heteroresistance to carbapenems in Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2005
S, Pournaras, A, Ikonomidis, A, Markogiannakis, A N, Maniatis, A, Tsakris   +4 more
openaire   +2 more sources

Widespread heteroresistance to antibiotics in Lactobacillus species

Abstract Lactobacilli are prevalent members of the intestinal and reproductive tract microbiota of humans and other species. They are commonly used in probiotics and various food products due to their beneficial effects on human health.
Rivera-Rodriguez, Dormarie E., Busby, Chayse, Cervantes-Barragan, Luisa, Weiss, David S.   +3 more
openaire   +2 more sources

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +1 more source